Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/42583
DC FieldValueLanguage
dc.contributor.authorDavalos, V.en_US
dc.contributor.authorDopeso, H.en_US
dc.contributor.authorVelho, S.en_US
dc.contributor.authorFerreira, A. M.en_US
dc.contributor.authorCirnes, L.en_US
dc.contributor.authorDíaz-Chico, N.en_US
dc.contributor.authorBilbao, C.en_US
dc.contributor.authorRamírez, R.en_US
dc.contributor.authorRodríguez, G.en_US
dc.contributor.authorFalcón, O.en_US
dc.contributor.authorLeón, L.en_US
dc.contributor.authorNiessen, R. C.en_US
dc.contributor.authorKeller, G.en_US
dc.contributor.authorDallenbach-Hellweg, G.en_US
dc.contributor.authorEspín, E.en_US
dc.contributor.authorArmengol, M.en_US
dc.contributor.authorPlaja, A.en_US
dc.contributor.authorPerucho, M.en_US
dc.contributor.authorImai, K.en_US
dc.contributor.authorYamamoto, H.en_US
dc.contributor.authorGebert, J. F.en_US
dc.contributor.authorDiaz-Chico, J. C.en_US
dc.contributor.authorHofstra, R. M.en_US
dc.contributor.authorWoerner, S. M.en_US
dc.contributor.authorSeruca, R.en_US
dc.contributor.authorSchwartz, S.en_US
dc.contributor.authorArango, D.en_US
dc.contributor.otherBILBAO SIEYRO, CRISTINA
dc.contributor.otherVelho, Sergia-
dc.contributor.otherDiaz-Chico, Juan-
dc.contributor.otherRamirez-Moreno, Raquel-
dc.contributor.otherArango, Diego-
dc.contributor.otherArango, Diego-
dc.contributor.otherWoerner, Stefan-
dc.contributor.otherSchwartz, Simo-
dc.contributor.otherseruca, raquel-
dc.contributor.otherSeruca, Raquel-
dc.contributor.otherRodriguez Gonzalez, Francisco G-
dc.contributor.otherArmengol, Manuel-
dc.contributor.otherDopeso, Higinio-
dc.contributor.otherFerreira, Ana-
dc.contributor.otherHofstra, Robert-
dc.contributor.otherPerucho, Manuel-
dc.contributor.otherPerucho, Manuel-
dc.date.accessioned2018-11-21T10:13:47Z-
dc.date.available2018-11-21T10:13:47Z-
dc.date.issued2007en_US
dc.identifier.issn0950-9232en_US
dc.identifier.urihttp://hdl.handle.net/10553/42583-
dc.description.abstractThe EPH/EFN family of receptor tyrosine kinases regulates cell adhesion and migration and has an important role in controlling cell positioning in the normal intestinal epithelium. Inactivation of EPHB2 has recently been shown to accelerate tumorigenesis in the colon and rectum, and we have previously demonstrated frequent frameshift mutations (41%) in an A9 coding microsatellite repeat in exon 17 of EPHB2 in colorectal tumors with microsatellite instability (MSI). In this study, we extended these analyses to extracolonic MSI cancers, and found frameshift EPHB2 mutations in 39% (25/64) of gastric tumors and 14% (8/56) of endometrial tumors. Regression analysis of these EPHB2 mutation data on the basis of our previously proposed statistical model identified EPHB2 as a selective target of frameshift mutations in MSI gastric cancers but not in MSI endometrial carcinomas. These results suggest a functional role for EPHB2 in gastric tumor progression, and emphasize the differences between the tumorigenic processes in MSI gastrointestinal and endometrial cancer.en_US
dc.languageengen_US
dc.publisher0950-9232-
dc.relation.ispartofOncogeneen_US
dc.sourceOncogene[ISSN 0950-9232],v. 26 (2), p. 308-311en_US
dc.subject320101 Oncologíaen_US
dc.subject.otherEPHB2en_US
dc.subject.otherCanceren_US
dc.subject.otherMicrosatellite instabilityen_US
dc.subject.otherColorectalen_US
dc.subject.otherStomachen_US
dc.subject.otherEndometriumen_US
dc.titleHigh EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instabilityen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1038/sj.onc.1209780
dc.identifier.scopus33846239265-
dc.identifier.isi000243398300015-
dcterms.isPartOfOncogene-
dcterms.sourceOncogene [ISSN 0950-9232], v. 26 (2), p. 308-311-
dc.contributor.authorscopusid9740264500-
dc.contributor.authorscopusid15764444000-
dc.contributor.authorscopusid8738558400-
dc.contributor.authorscopusid35073842300-
dc.contributor.authorscopusid6602370994-
dc.contributor.authorscopusid25723175700-
dc.contributor.authorscopusid12759635600-
dc.contributor.authorscopusid12759883400-
dc.contributor.authorscopusid57196904626-
dc.contributor.authorscopusid6603752888-
dc.contributor.authorscopusid19234933700-
dc.contributor.authorscopusid8568400300-
dc.contributor.authorscopusid7201829156-
dc.contributor.authorscopusid7006163538-
dc.contributor.authorscopusid23003921900-
dc.contributor.authorscopusid35420890700-
dc.contributor.authorscopusid6603726131-
dc.contributor.authorscopusid7006337861-
dc.contributor.authorscopusid36046668400-
dc.contributor.authorscopusid55628547126-
dc.contributor.authorscopusid55628546991
dc.contributor.authorscopusid7004514270-
dc.contributor.authorscopusid6701492347-
dc.contributor.authorscopusid7006771436-
dc.contributor.authorscopusid6602441936-
dc.contributor.authorscopusid7006207833-
dc.contributor.authorscopusid7403605083-
dc.contributor.authorscopusid6602825121-
dc.description.lastpage311-
dc.description.firstpage308-
dc.relation.volume26-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000243398300015-
dc.contributor.daisngid1545681
dc.contributor.daisngid2224117
dc.contributor.daisngid2040488
dc.contributor.daisngid2023934
dc.contributor.daisngid1252168
dc.contributor.daisngid4287772
dc.contributor.daisngid1724161
dc.contributor.daisngid2205075
dc.contributor.daisngid2567033
dc.contributor.daisngid5234417
dc.contributor.daisngid2891739
dc.contributor.daisngid1217537
dc.contributor.daisngid411603
dc.contributor.daisngid5422159
dc.contributor.daisngid2282030
dc.contributor.daisngid11456149
dc.contributor.daisngid349661
dc.contributor.daisngid527187
dc.contributor.daisngid529853
dc.contributor.daisngid254702
dc.contributor.daisngid29919276
dc.contributor.daisngid623586
dc.contributor.daisngid348212
dc.contributor.daisngid28863
dc.contributor.daisngid4069115
dc.contributor.daisngid3645623
dc.contributor.daisngid749099
dc.contributor.daisngid52170
dc.contributor.daisngid1695086
dc.contributor.daisngid60137
dc.contributor.daisngid35039121
dc.contributor.daisngid515841
dc.contributor.daisngid1777160
dc.contributor.daisngid670786
dc.identifier.investigatorRIDR-6779-2018
dc.identifier.investigatorRIDB-8501-2013-
dc.identifier.investigatorRIDH-1527-2015-
dc.identifier.investigatorRIDJ-4905-2018-
dc.identifier.investigatorRIDH-8205-2012-
dc.identifier.investigatorRIDM-5667-2016-
dc.identifier.investigatorRIDA-2187-2010-
dc.identifier.investigatorRIDH-7776-2012-
dc.identifier.investigatorRIDF-8187-2011-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Davalos, V
dc.contributor.wosstandardWOS:Dopeso, H
dc.contributor.wosstandardWOS:Velho, S
dc.contributor.wosstandardWOS:Ferreira, AM
dc.contributor.wosstandardWOS:Cirnes, L
dc.contributor.wosstandardWOS:Diaz-Chico, N
dc.contributor.wosstandardWOS:Bilbao, C
dc.contributor.wosstandardWOS:Ramirez, R
dc.contributor.wosstandardWOS:Rodriguez, G
dc.contributor.wosstandardWOS:Falcon, O
dc.contributor.wosstandardWOS:Leon, L
dc.contributor.wosstandardWOS:Niessen, RC
dc.contributor.wosstandardWOS:Keller, G
dc.contributor.wosstandardWOS:Dallenbach-Hellweg, G
dc.contributor.wosstandardWOS:Espin, E
dc.contributor.wosstandardWOS:Armengol, M
dc.contributor.wosstandardWOS:Plaja, A
dc.contributor.wosstandardWOS:Perucho, M
dc.contributor.wosstandardWOS:Imai, K
dc.contributor.wosstandardWOS:Yamamoto, H
dc.contributor.wosstandardWOS:Gebert, JF
dc.contributor.wosstandardWOS:Diaz-Chico, JC
dc.contributor.wosstandardWOS:Hofstra, RM
dc.contributor.wosstandardWOS:Woerner, SM
dc.contributor.wosstandardWOS:Seruca, R
dc.contributor.wosstandardWOS:Schwartz, S
dc.contributor.wosstandardWOS:Arango, D
dc.date.coverdateEnero 2007
dc.identifier.ulpgces
dc.description.jcr6,44
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-0944-990X-
crisitem.author.orcid0000-0002-4796-1445-
crisitem.author.orcid0000-0002-0944-990X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameDíaz Chico, Juan Carlos-
crisitem.author.fullNameBilbao Sieyro, Cristina-
crisitem.author.fullNameDíaz Chico, Juan Carlos-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

37
checked on Dec 1, 2024

WEB OF SCIENCETM
Citations

36
checked on Nov 24, 2024

Page view(s)

76
checked on Jul 13, 2024

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.