Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/42583
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Davalos, V. | en_US |
dc.contributor.author | Dopeso, H. | en_US |
dc.contributor.author | Velho, S. | en_US |
dc.contributor.author | Ferreira, A. M. | en_US |
dc.contributor.author | Cirnes, L. | en_US |
dc.contributor.author | Díaz-Chico, N. | en_US |
dc.contributor.author | Bilbao, C. | en_US |
dc.contributor.author | Ramírez, R. | en_US |
dc.contributor.author | Rodríguez, G. | en_US |
dc.contributor.author | Falcón, O. | en_US |
dc.contributor.author | León, L. | en_US |
dc.contributor.author | Niessen, R. C. | en_US |
dc.contributor.author | Keller, G. | en_US |
dc.contributor.author | Dallenbach-Hellweg, G. | en_US |
dc.contributor.author | Espín, E. | en_US |
dc.contributor.author | Armengol, M. | en_US |
dc.contributor.author | Plaja, A. | en_US |
dc.contributor.author | Perucho, M. | en_US |
dc.contributor.author | Imai, K. | en_US |
dc.contributor.author | Yamamoto, H. | en_US |
dc.contributor.author | Gebert, J. F. | en_US |
dc.contributor.author | Diaz-Chico, J. C. | en_US |
dc.contributor.author | Hofstra, R. M. | en_US |
dc.contributor.author | Woerner, S. M. | en_US |
dc.contributor.author | Seruca, R. | en_US |
dc.contributor.author | Schwartz, S. | en_US |
dc.contributor.author | Arango, D. | en_US |
dc.contributor.other | BILBAO SIEYRO, CRISTINA | |
dc.contributor.other | Velho, Sergia | - |
dc.contributor.other | Diaz-Chico, Juan | - |
dc.contributor.other | Ramirez-Moreno, Raquel | - |
dc.contributor.other | Arango, Diego | - |
dc.contributor.other | Arango, Diego | - |
dc.contributor.other | Woerner, Stefan | - |
dc.contributor.other | Schwartz, Simo | - |
dc.contributor.other | seruca, raquel | - |
dc.contributor.other | Seruca, Raquel | - |
dc.contributor.other | Rodriguez Gonzalez, Francisco G | - |
dc.contributor.other | Armengol, Manuel | - |
dc.contributor.other | Dopeso, Higinio | - |
dc.contributor.other | Ferreira, Ana | - |
dc.contributor.other | Hofstra, Robert | - |
dc.contributor.other | Perucho, Manuel | - |
dc.contributor.other | Perucho, Manuel | - |
dc.date.accessioned | 2018-11-21T10:13:47Z | - |
dc.date.available | 2018-11-21T10:13:47Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.issn | 0950-9232 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/42583 | - |
dc.description.abstract | The EPH/EFN family of receptor tyrosine kinases regulates cell adhesion and migration and has an important role in controlling cell positioning in the normal intestinal epithelium. Inactivation of EPHB2 has recently been shown to accelerate tumorigenesis in the colon and rectum, and we have previously demonstrated frequent frameshift mutations (41%) in an A9 coding microsatellite repeat in exon 17 of EPHB2 in colorectal tumors with microsatellite instability (MSI). In this study, we extended these analyses to extracolonic MSI cancers, and found frameshift EPHB2 mutations in 39% (25/64) of gastric tumors and 14% (8/56) of endometrial tumors. Regression analysis of these EPHB2 mutation data on the basis of our previously proposed statistical model identified EPHB2 as a selective target of frameshift mutations in MSI gastric cancers but not in MSI endometrial carcinomas. These results suggest a functional role for EPHB2 in gastric tumor progression, and emphasize the differences between the tumorigenic processes in MSI gastrointestinal and endometrial cancer. | en_US |
dc.language | eng | en_US |
dc.publisher | 0950-9232 | - |
dc.relation.ispartof | Oncogene | en_US |
dc.source | Oncogene[ISSN 0950-9232],v. 26 (2), p. 308-311 | en_US |
dc.subject | 320101 Oncología | en_US |
dc.subject.other | EPHB2 | en_US |
dc.subject.other | Cancer | en_US |
dc.subject.other | Microsatellite instability | en_US |
dc.subject.other | Colorectal | en_US |
dc.subject.other | Stomach | en_US |
dc.subject.other | Endometrium | en_US |
dc.title | High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability | en_US |
dc.type | info:eu-repo/semantics/Article | es |
dc.type | Article | es |
dc.identifier.doi | 10.1038/sj.onc.1209780 | |
dc.identifier.scopus | 33846239265 | - |
dc.identifier.isi | 000243398300015 | - |
dcterms.isPartOf | Oncogene | - |
dcterms.source | Oncogene [ISSN 0950-9232], v. 26 (2), p. 308-311 | - |
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dc.contributor.authorscopusid | 6602825121 | - |
dc.description.lastpage | 311 | - |
dc.description.firstpage | 308 | - |
dc.relation.volume | 26 | - |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000243398300015 | - |
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dc.identifier.investigatorRID | R-6779-2018 | |
dc.identifier.investigatorRID | B-8501-2013 | - |
dc.identifier.investigatorRID | H-1527-2015 | - |
dc.identifier.investigatorRID | J-4905-2018 | - |
dc.identifier.investigatorRID | H-8205-2012 | - |
dc.identifier.investigatorRID | M-5667-2016 | - |
dc.identifier.investigatorRID | A-2187-2010 | - |
dc.identifier.investigatorRID | H-7776-2012 | - |
dc.identifier.investigatorRID | F-8187-2011 | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.contributor.wosstandard | WOS:Davalos, V | |
dc.contributor.wosstandard | WOS:Dopeso, H | |
dc.contributor.wosstandard | WOS:Velho, S | |
dc.contributor.wosstandard | WOS:Ferreira, AM | |
dc.contributor.wosstandard | WOS:Cirnes, L | |
dc.contributor.wosstandard | WOS:Diaz-Chico, N | |
dc.contributor.wosstandard | WOS:Bilbao, C | |
dc.contributor.wosstandard | WOS:Ramirez, R | |
dc.contributor.wosstandard | WOS:Rodriguez, G | |
dc.contributor.wosstandard | WOS:Falcon, O | |
dc.contributor.wosstandard | WOS:Leon, L | |
dc.contributor.wosstandard | WOS:Niessen, RC | |
dc.contributor.wosstandard | WOS:Keller, G | |
dc.contributor.wosstandard | WOS:Dallenbach-Hellweg, G | |
dc.contributor.wosstandard | WOS:Espin, E | |
dc.contributor.wosstandard | WOS:Armengol, M | |
dc.contributor.wosstandard | WOS:Plaja, A | |
dc.contributor.wosstandard | WOS:Perucho, M | |
dc.contributor.wosstandard | WOS:Imai, K | |
dc.contributor.wosstandard | WOS:Yamamoto, H | |
dc.contributor.wosstandard | WOS:Gebert, JF | |
dc.contributor.wosstandard | WOS:Diaz-Chico, JC | |
dc.contributor.wosstandard | WOS:Hofstra, RM | |
dc.contributor.wosstandard | WOS:Woerner, SM | |
dc.contributor.wosstandard | WOS:Seruca, R | |
dc.contributor.wosstandard | WOS:Schwartz, S | |
dc.contributor.wosstandard | WOS:Arango, D | |
dc.date.coverdate | Enero 2007 | |
dc.identifier.ulpgc | Sí | es |
dc.description.jcr | 6,44 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.orcid | 0000-0002-0944-990X | - |
crisitem.author.orcid | 0000-0002-4796-1445 | - |
crisitem.author.orcid | 0000-0002-0944-990X | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Díaz Chico, Juan Carlos | - |
crisitem.author.fullName | Bilbao Sieyro, Cristina | - |
crisitem.author.fullName | Díaz Chico, Juan Carlos | - |
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