Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/42467
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dc.contributor.authorHernández Castellano, Lorenzo Enriqueen_US
dc.contributor.authorFerreira, Ana M.en_US
dc.contributor.authorNanni, Paoloen_US
dc.contributor.authorGrossmann, Jonasen_US
dc.contributor.authorArguello, Anastasioen_US
dc.contributor.authorCapote, Juanen_US
dc.contributor.authorCai, Guohongen_US
dc.contributor.authorLippolis, Johnen_US
dc.contributor.authorCastro, Noemien_US
dc.contributor.authorde Almeida, Andre M.en_US
dc.contributor.otherArguello, Anastasio-
dc.contributor.otherAlmeida, Andre-
dc.contributor.otherHernandez-Castellano, Lorenzo Enrique-
dc.contributor.otherCastro, Noemi-
dc.contributor.otherFerreira, Ana-
dc.date.accessioned2018-11-15T11:18:33Z-
dc.date.available2018-11-15T11:18:33Z-
dc.date.issued2016en_US
dc.identifier.issn1874-3919en_US
dc.identifier.urihttp://hdl.handle.net/10553/42467-
dc.description.abstractSeasonal weight loss (SWL) is a significant limitation to animal production. Breeds that have evolved in harsh climates have acquired tolerance to SWL through selection. Herein, label free proteomics was used to characterize the effects of SWL in two goat breeds with different levels of adaptation to nutritional stress: Majorera (tolerant) and Palmera (susceptible). Nine Majorera and 10 Palmera dairy goats were used, divided in 4 sets, 2 for each breed: underfed and a control group: Majorera Control (MC), Palmera Control (PC), Majorera Restricted (ME) and Palmera Restricted (PE). At day 22, mammary gland biopsy samples were obtained. Label free proteomic analysis enabled the identification of over 1000 proteins, of which 96 showed differential expression between two of the groups within studied comparisons. Majorera breed showed higher expression of immune system related proteins. In contrast, Palmera breed showed higher expression of proteins related to apoptosis. Results indicate that the two goat breeds have a distinct metabolism reaction to SWL, and that proteins related to the immune system and apoptosis such as cadherin-13, collagen alpha-1, nidogen-2, clusterin and protein s100-A8 could be considered putative candidates as markers of tolerance to SWL. Biological significance Seasonal weight loss (SWL) is one of the major constraints to animal production in the tropics. We compared the proteomics profiles of two dairy goat breeds with different levels of tolerance to SWL under control and feed restriction conditions using label free proteomics. We have identified over 1000 proteins in the goat mammary gland, of which 96 showed differential expression. Despite the fact that both breeds showed a decrease in the number of proteins related to protein, carbohydrates and fat biosynthesis, the tolerant breed showed higher expression of immune system related proteins compared to the susceptible breed. On the contrary, the susceptible breed had higher expression of apoptosis related proteins indicating that both breeds reacted differently to weight loss and that proteins related to the immune system and apoptosis such as cadherin-13, collagen alpha 1, nidogen-2 or clusterin may be suggested as markers of tolerance to SWL.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Proteomicsen_US
dc.sourceJournal Of Proteomics[ISSN 1874-3919],v. 145, p. 60-69en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject.otherGoaten_US
dc.subject.otherLabel-free proteomicsen_US
dc.subject.otherMammary glanden_US
dc.subject.otherSeasonal weight lossen_US
dc.titleThe goat (Capra hircus) mammary gland secretory tissue proteome as influenced by weight loss: A study using label free proteomicsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jprot.2016.03.030en_US
dc.identifier.pmid27017928-
dc.identifier.scopus84963550577-
dc.identifier.isi000383931000007-
dc.contributor.orcid#NODATA#-
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dcterms.isPartOfJournal Of Proteomics-
dcterms.sourceJournal Of Proteomics[ISSN 1874-3919],v. 145, p. 60-69-
dc.contributor.authorscopusid36682092900-
dc.contributor.authorscopusid35073842300-
dc.contributor.authorscopusid55207232700-
dc.contributor.authorscopusid9333123900-
dc.contributor.authorscopusid6701710018-
dc.contributor.authorscopusid6602424338-
dc.contributor.authorscopusid8247225400-
dc.contributor.authorscopusid6602973582-
dc.contributor.authorscopusid57200208399-
dc.contributor.authorscopusid55945318600-
dc.description.lastpage69en_US
dc.description.firstpage60en_US
dc.relation.volume145en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000383931000007-
dc.contributor.daisngid1033930-
dc.contributor.daisngid2023934-
dc.contributor.daisngid272714-
dc.contributor.daisngid28126111-
dc.contributor.daisngid298051-
dc.contributor.daisngid383596-
dc.contributor.daisngid1251903-
dc.contributor.daisngid663857-
dc.contributor.daisngid330531-
dc.contributor.daisngid1374867-
dc.contributor.daisngid493849-
dc.identifier.investigatorRIDB-4493-2010-
dc.identifier.investigatorRIDI-4369-2013-
dc.identifier.investigatorRIDT-1034-2016-
dc.identifier.investigatorRIDF-9621-2016-
dc.identifier.investigatorRIDNo ID-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Hernandez-Castellano, LE-
dc.contributor.wosstandardWOS:Ferreira, AM-
dc.contributor.wosstandardWOS:Nanni, P-
dc.contributor.wosstandardWOS:Grossmann, J-
dc.contributor.wosstandardWOS:Arguello, A-
dc.contributor.wosstandardWOS:Capote, J-
dc.contributor.wosstandardWOS:Cai, GH-
dc.contributor.wosstandardWOS:Lippolis, J-
dc.contributor.wosstandardWOS:Castro, N-
dc.contributor.wosstandardWOS:de Almeida, AM-
dc.date.coverdateAgosto 2016en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,383
dc.description.jcr3,914
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-2729-0434-
crisitem.author.orcid0000-0002-4426-0678-
crisitem.author.orcid0000-0002-3026-2031-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameHernández Castellano, Lorenzo Enrique-
crisitem.author.fullNameArgüello Henríquez, Anastasio-
crisitem.author.fullNameCapote Álvarez, Juan Francisco-
crisitem.author.fullNameCastro Navarro, Noemí-
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