Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/42139
DC FieldValueLanguage
dc.contributor.authorLópez-Rodríguez, M.en_US
dc.contributor.authorHerrera-Ramos, E.en_US
dc.contributor.authorSolé-Violán, J.en_US
dc.contributor.authorRuíz-Hernández, J. J.en_US
dc.contributor.authorBorderías, L.en_US
dc.contributor.authorHorcajada, J.P.en_US
dc.contributor.authorLerma-Chippirraz, E.en_US
dc.contributor.authorRajas, O.en_US
dc.contributor.authorBriones, M.en_US
dc.contributor.authorPérez-González, M. C.en_US
dc.contributor.authorGarcía-Bello, M. A.en_US
dc.contributor.authorLópez-Granados, E.en_US
dc.contributor.authorRodríguez De Castro, Felipe Carlos B.en_US
dc.contributor.authorRodríguez-Gallego, C.en_US
dc.date.accessioned2018-10-15T08:53:13Z-
dc.date.available2018-10-15T08:53:13Z-
dc.date.issued2016en_US
dc.identifier.issn0934-9723en_US
dc.identifier.urihttp://hdl.handle.net/10553/42139-
dc.description.abstractInfluenza virus infection (IVI) is typically subclinical or causes a self-limiting upper respiratory disease. However, in a small subset of patients IVI rapidly progresses to primary viral pneumonia (PVP) with respiratory failure; a minority of patients require intensive care unit admission. Inherited and acquired variability in host immune responses may influence susceptibility and outcome of IVI. However, the molecular basis of such human factors remains largely elusive. It has been proposed that homozygosity for IFITM3 rs12252-C is associated with a population-attributable risk of 5.4 % for severe IVI in Northern Europeans and 54.3 % for severe H1N1pdm infection in Chinese. A total of 148 patients with confirmed IVI were considered for recruitment; 118 Spanish patients (60 of them hospitalized with PVP) and 246 healthy Spanish individuals were finally included in the statistical analysis. PCR-RFLP was used with confirmation by Sanger sequencing. The allele frequency for rs12252-C was found to be 3.5 % among the general Spanish population. We found no rs12252-C homozygous individuals in our control group. The only Spanish patient homozygous for rs12252-C had a neurological disorder (a known risk factor for severe IVI) and mild influenza. Our data do not suggest a role of rs12252-C in the development of severe IVI in our population. These data may be relevant to recognize whether patients homozygous for rs12252-C are at risk of severe influenza, and hence require individualized measures in the case of IVI.en_US
dc.languageengen_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology and Infectious Diseasesen_US
dc.sourceEuropean Journal of Clinical Microbiology and Infectious Diseases [ISSN 0934-9723], v. 35 (11), p. 1811-1817en_US
dc.subject3201 Ciencias clínicasen_US
dc.subject3207 Patologíaen_US
dc.subject.otherSusceptibility
dc.subject.otherCommunity
dc.titleIFITM3 and severe influenza virus infection. No evidence of genetic associationen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1007/s10096-016-2732-7
dc.identifier.scopus84982893713-
dc.identifier.isi000386157300012
dc.contributor.authorscopusid56215964100
dc.contributor.authorscopusid36952964800
dc.contributor.authorscopusid24391710100
dc.contributor.authorscopusid13608890100
dc.contributor.authorscopusid16168865800
dc.contributor.authorscopusid7004469799
dc.contributor.authorscopusid51561933800
dc.contributor.authorscopusid6505890335
dc.contributor.authorscopusid7006010004
dc.contributor.authorscopusid56299503000
dc.contributor.authorscopusid36099016000
dc.contributor.authorscopusid8270998000
dc.contributor.authorscopusid55942667000
dc.contributor.authorscopusid6602114379
dc.description.lastpage1817-
dc.identifier.issue11-
dc.description.firstpage1811-
dc.relation.volume35-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid5010463
dc.contributor.daisngid2130906
dc.contributor.daisngid31934158
dc.contributor.daisngid4541689
dc.contributor.daisngid857548
dc.contributor.daisngid217580
dc.contributor.daisngid9735579
dc.contributor.daisngid1134484
dc.contributor.daisngid1423003
dc.contributor.daisngid8851959
dc.contributor.daisngid1700450
dc.contributor.daisngid848362
dc.contributor.daisngid464249
dc.contributor.daisngid603384
dc.contributor.wosstandardWOS:Lopez-Rodriguez, M
dc.contributor.wosstandardWOS:Herrera-Ramos, E
dc.contributor.wosstandardWOS:Sole-Violan, J
dc.contributor.wosstandardWOS:Ruiz-Hernandez, JJ
dc.contributor.wosstandardWOS:Borderias, L
dc.contributor.wosstandardWOS:Horcajada, JP
dc.contributor.wosstandardWOS:Lerma-Chippirraz, E
dc.contributor.wosstandardWOS:Rajas, O
dc.contributor.wosstandardWOS:Briones, M
dc.contributor.wosstandardWOS:Perez-Gonzalez, MC
dc.contributor.wosstandardWOS:Garcia-Bello, MA
dc.contributor.wosstandardWOS:Lopez-Granados, E
dc.contributor.wosstandardWOS:de Castro, FR
dc.contributor.wosstandardWOS:Rodriguez-Gallego, C
dc.date.coverdateNoviembre 2016
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptPatología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptFarmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0001-5393-5529-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRuiz Hernández, José Juan-
crisitem.author.fullNameRodríguez De Castro, Felipe Carlos B.-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
crisitem.author.departamentoCiencias Médicas y Quirúrgicas-
crisitem.author.departamentoCiencias Médicas y Quirúrgicas-
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