Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/42114
Campo DC Valoridioma
dc.contributor.authorNavarro-Valverde, Cristinaen_US
dc.contributor.authorSosa Henríquez, Manuel Joséen_US
dc.contributor.authorAlhambra-Expósito, Maria Rosaen_US
dc.contributor.authorQuesada-Gómez, José Manuelen_US
dc.date.accessioned2018-10-10T08:57:50Z-
dc.date.available2018-10-10T08:57:50Z-
dc.date.issued2016en_US
dc.identifier.issn0960-0760en_US
dc.identifier.urihttp://hdl.handle.net/10553/42114-
dc.description.abstractDespite the discussion on the optimal threshold of 25-hydroxyvitamin D serum level continues, there is now consensus on the fact that post-menopausal and elderly populations have inadequate Vitamin D serum levels worldwide. The adjustment of these levels is necessary to improve both bone and general health, as it is to optimize bone response to antiresortive treatments. It is recommended, as endorsed by international clinical guides, to use Vitamin D3, the physiological form of Vitamin D, in a dose range between 600–2000 IU. It should be administered on a daily basis or on its weekly or monthly equivalents. In Spain, the use of calcidiol (25(OH)D3) at the same dose than Vitamin D3 is the most extended prescription, notwithstanding the available evidence stating that they are not equipotent. This may lead to over-dosage. In order to provide evidence on this circumstance, a convenience study was performed. Four groups of ten post-menopausal osteoporotic women each (average age 67), deficient in Vitamin D ((25(OH)D 37.5 ± 10 nmol/L)) were enrolled. Each group followed a different treatment regimen: (G1) vitamin D3 20 μg/day [800 IU/day]; (G2) 25 (OH)D3 20 μg/day; (G3) 25(OH)D3 266 μg/week and (G4) 25(OH)D3 0.266 mg every two weeks. 25(OH)D levels were measured for each group at 0, 6 and 12 months, with the following results: G1 (40.5 ± 4.7;80.0 ± 2; 86.2 ± 23.7), G2 (37,2 ± 4.2; 161 ± 21.7;188.0 ± 24.0), G3 (38 ± 3.7;213.5 ± 80.0; 233.0 ± 81.2), G4 (39.5 ± 4;164.5 ± 41,7;210.5 ± 22.2). These data reveal that both metabolites are not equipotent. Calcidiol is faster and 3–6 times more potent to obtain serum levels of 25(OH)D in the medium to long term. This circumstance must be assessed and included in the therapeutic prescription guides for Osteoporosis, since it should be of concern when planning and prescribing treatments to normalize serum levels of 25(OH)D3 and avoid potential adverse impacts.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Steroid Biochemistry and Molecular Biologyen_US
dc.sourceJournal of Steroid Biochemistry and Molecular Biology [ISSN 0960-0760], v. 164, p. 205-208en_US
dc.subject320502 Endocrinologíaen_US
dc.subject320714 Osteopatologíaen_US
dc.subject.otherCalcidiolen_US
dc.subject.otherOsteoporosisen_US
dc.subject.otherVitamin D3en_US
dc.titleVitamin D3 and calcidiol are not equipotenten_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.typeconferenceObjecten_US
dc.relation.conference18th Workshop on Vitamin Den_US
dc.identifier.doi10.1016/j.jsbmb.2016.01.014en_US
dc.identifier.scopus84957686411-
dc.identifier.isi000388157000035-
dc.contributor.authorscopusid55437496000-
dc.contributor.authorscopusid7004134221-
dc.contributor.authorscopusid57210033526-
dc.contributor.authorscopusid55487387200-
dc.contributor.authorscopusid6602887521-
dc.description.lastpage208en_US
dc.description.firstpage205en_US
dc.relation.volume164en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Actas de congresosen_US
dc.contributor.daisngid7260657-
dc.contributor.daisngid574595-
dc.contributor.daisngid6248544-
dc.contributor.daisngid1212244-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Navarro-Valverde, C-
dc.contributor.wosstandardWOS:Sosa-Henriquez, M-
dc.contributor.wosstandardWOS:Alhambra-Exposito, MR-
dc.contributor.wosstandardWOS:Quesada-Gomez, JM-
dc.date.coverdateNoviembre 2016en_US
dc.identifier.conferenceidevents121003-
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,49
dc.description.jcr4,561
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.orcid0000-0001-6845-2933-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.fullNameSosa Henríquez,Manuel José-
crisitem.event.eventsstartdate21-04-2015-
crisitem.event.eventsenddate24-04-2015-
Colección:Actas de congresos
Vista resumida

Citas SCOPUSTM   

39
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

36
actualizado el 25-feb-2024

Visitas

83
actualizado el 16-sep-2023

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.