Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/41999
DC FieldValueLanguage
dc.contributor.authorOdden, Aneen_US
dc.contributor.authorEnemark, Heidi L.en_US
dc.contributor.authorRuiz Reyes, Antonioen_US
dc.contributor.authorRobertson, Lucy J.en_US
dc.contributor.authorErsdal, Cecilieen_US
dc.contributor.authorNes, Silje K.en_US
dc.contributor.authorTommerberg, Vibekeen_US
dc.contributor.authorStuen, Snorreen_US
dc.date.accessioned2018-09-26T09:21:24Z-
dc.date.available2018-09-26T09:21:24Z-
dc.date.issued2018en_US
dc.identifier.issn1756-3305en_US
dc.identifier.urihttp://hdl.handle.net/10553/41999-
dc.description.abstractBackground Coccidiosis due to Eimeria spp. infections in lambs causes increased mortality and substantial production losses, and anticoccidials are important for control of the infection. Anticoccidial resistance has been reported in poultry and swine, and we recently described reduced toltrazuril efficacy in ovine Eimeria spp. in some Norwegian sheep farms using a newly developed faecal oocyst count reduction test (FOCRT). The aim of the present study was to use a controlled efficacy trial to assess the efficacy of toltrazuril against a field isolate suspected of being resistant. Methods Twenty lambs, 17–22 days old and raised protected against exposure to coccidia, were infected with a field isolate of 100,000 Eimeria spp. oocysts. This isolate was obtained from a farm with a previously calculated drug efficacy of 56% (95% confidence interval: -433.9 to 96.6%). At day 7 post-infection, 10 of the lambs were orally treated with 20 mg/kg toltrazuril (Baycox Sheep vet., Bayer Animal Health), while the other 10 lambs (controls) were given physiological saline. Clinical examinations were conducted, and weight gains recorded. Daily faecal samples were scored for diarrhoea on a scale from 1 to 5, and oocyst excretion was determined using a modified McMaster technique. Oocysts were morphologically identified to species level. At 17–24 days post-infection, the lambs were euthanized and necropsied. Results The tested Eimeria isolate was resistant against toltrazuril, and resistance was seen in both pathogenic and non-pathogenic species. In addition, no significant differences in faecal score, growth, gross pathology or histological changes were identified between the two groups. The pathogenic E. ovinoidalis was the dominant species, and no significant difference in the individual prevalence of E. ovinoidalis post-treatment was found between treated (66.9%) and control lambs (61.9%). Other species identified included E. crandallis/weybridgensis, E. parva, E. marsica, E. faurei, E. pallida, E. ahsata and E. bakuensis. Conclusions This study confirms toltrazuril resistance in ovine Eimeria spp.; in addition, the data support the use of FOCRT as an appropriate tool for field evaluation of anticoccidial efficacy. Due to limited anticoccidial treatment alternatives, these findings may have important implications for the sheep industry, particularly in northern Europe.en_US
dc.languageengen_US
dc.publisher1756-3305
dc.relation.ispartofParasites and Vectorsen_US
dc.sourceParasites & Vectors [ISSN 1756-3305], v. 11, article number 394en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject.otherControlled efficacy testen_US
dc.subject.otherAnticoccidial resistanceen_US
dc.subject.otherToltrazurilen_US
dc.subject.otherEimeria spp.en_US
dc.subject.otherEimeria ovinoidalisen_US
dc.subject.otherSheepen_US
dc.titleControlled efficacy trial confirming toltrazuril resistance in a field isolate of ovine Eimeria sppen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1186/s13071-018-2976-4
dc.identifier.scopus85049527711
dc.identifier.isi000437517300001-
dc.contributor.authorscopusid57193265897
dc.contributor.authorscopusid7004124507
dc.contributor.authorscopusid57201387360
dc.contributor.authorscopusid7201408426
dc.contributor.authorscopusid7801361075
dc.contributor.authorscopusid55228472500
dc.contributor.authorscopusid57202832528
dc.contributor.authorscopusid7003697130
dc.relation.volume11-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid7631748
dc.contributor.daisngid849207
dc.contributor.daisngid1497623
dc.contributor.daisngid151362
dc.contributor.daisngid2122261
dc.contributor.daisngid4899632
dc.contributor.daisngid25904141
dc.contributor.daisngid461267
dc.contributor.wosstandardWOS:Odden, A
dc.contributor.wosstandardWOS:Enemark, HL
dc.contributor.wosstandardWOS:Ruiz, A
dc.contributor.wosstandardWOS:Robertson, LJ
dc.contributor.wosstandardWOS:Ersdal, C
dc.contributor.wosstandardWOS:Nes, SK
dc.contributor.wosstandardWOS:Tommerberg, V
dc.contributor.wosstandardWOS:Stuen, S
dc.date.coverdateJulio 2018
dc.identifier.ulpgces
dc.description.sjr1,565
dc.description.jcr3,031
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptParasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-0668-5496-
crisitem.author.parentorgPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.fullNameRuiz Reyes, Antonio-
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