Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/41939
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dc.contributor.authorTorrecillas, S.en_US
dc.contributor.authorRivero-Ramírez, F.en_US
dc.contributor.authorIzquierdo, M. S.en_US
dc.contributor.authorCaballero, M. J.en_US
dc.contributor.authorMakol, A.en_US
dc.contributor.authorSuarez-Bregua, P.en_US
dc.contributor.authorFernández-Montero, A.en_US
dc.contributor.authorRotllant, J.en_US
dc.contributor.authorMontero, D.en_US
dc.date.accessioned2018-09-14T12:13:05Z-
dc.date.available2018-09-14T12:13:05Z-
dc.date.issued2018en_US
dc.identifier.issn1050-4648en_US
dc.identifier.urihttp://hdl.handle.net/10553/41939-
dc.description.abstractThe aim of this study was to assess the effects of dietary mannan oligosaccharides (MOS), Pediococcus acidilactici or their conjunction as a synbiotic in low fish meal (FM) and fish oil (FO) based diets on European sea bass (Dicentrarchus labrax) disease resistance and gut health. For that purpose, sea bass juveniles were fed one of 6 diets containing different combinations of MOS (Biomos®and Actigen©; Alltech, Inc., Kentucky, USA) and Pediococcus acidilactici (BAC, Bactocell®; Lallemand Inc., Cardiff, UK) replacing standard carbohydrates as follows (MOS (%)/BAC (commercial recommendation): high prebiotic level (HP) = 0.6/0, low prebiotic level (LP) = 0.3/0, only probiotic (B) = 0/+, high prebiotic level plus probiotic (HPB) = 0.6/+, low prebiotic level plus probiotic (LPB) = 0.3/+, control (C) = 0/0 for 90 days. After 60 and 90 days of feeding trial, fish were subjected to an experimental infection against Vibrio anguillarum. Additionally, inducible nitric oxide synthase (iNOS) and tumor necrosis factor α (TNFα) gut patterns of immunopositivity and major histocompatibility complex class II (MHCII), transforming growth factor β (TGF-β), regulatory T-cell subset (CD4+T lymphocytes) and effector T cell (CD8α+T lymphocytes) gene expression patterns in gut by in situ hybridization were evaluated after 90 days of feeding. The effects of both additives on posterior gut through Gut Associated Lymphoid Tissue (GALT) gene expression was also studied. Fish fed the prebiotic and its combination with P. acidilactici presented increased weight regardless of the dose supplemented after 90 days of feeding, however no effect was detected on somatic indexes. For posterior gut, morphometric patterns and goblet cells density was not affected by MOS, P. acidilactici or its combination. Anti-iNOS and anti-TNFα gut immunopositivity patterns were mainly influenced by MOS supplementation and not by its combination with P. acidilactici. MHCII-β TCR-β CD4 and CD8-α positive cells distribution and incidence was not affected by diet. Fish fed HP dose presented a clear up-regulation of TNF-α cyclooxygenase-2 (COX-2), CD4 and IL10, whereas P. acidilactici dietary supplementation increased the number of interleukin-1β (IL1β) and COX-2 gene transcripts. Synbiotic supplementation resulted in a reduction of MOS-induced gut humoral proinflammatory response by increasing the expression of some cellular-immune system related genes. Fish mortality after V. anguillarum infection was reduced in fish fed LPB and LP diets compared to fish fed the non-suppelmented diet after 90 days of feeding. Thus, overall pointing to the combination of a low dose of MOS and P. acidilactici as synbiont (LPB) as a viable tool to potentiate European sea bass juvenile's growth and disease resistance when supplemented in low FM and FO diets.en_US
dc.languageengen_US
dc.publisher1050-4648
dc.relation.ispartofFish and Shellfish Immunologyen_US
dc.sourceFish and Shellfish Immunology[ISSN 1050-4648],v. 81, p. 10-20en_US
dc.subject310502 Pisciculturaen_US
dc.subject.otherEuropean sea bassen_US
dc.subject.otherAlternative mealsen_US
dc.subject.otherAlternative oils Prebioticsen_US
dc.subject.otherProbiotics Synbioticen_US
dc.subject.otherGALTen_US
dc.subject.otherDisease resistanceen_US
dc.titleFeeding European sea bass (Dicentrarchus labrax) juveniles with a functional synbiotic additive (mannan oligosaccharides and Pediococcus acidilactici): An effective tool to reduce low fishmeal and fish oil gut health effects?en_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.fsi.2018.07.007en_US
dc.identifier.scopus85049439885-
dc.identifier.isi000443665900002-
dc.contributor.authorscopusid21733894700-
dc.contributor.authorscopusid57193757119-
dc.contributor.authorscopusid7103111891-
dc.contributor.authorscopusid57209992208-
dc.contributor.authorscopusid21733546800-
dc.contributor.authorscopusid52264616200-
dc.contributor.authorscopusid57200550839-
dc.contributor.authorscopusid6603726424-
dc.contributor.authorscopusid35605929400-
dc.description.lastpage20en_US
dc.description.firstpage10en_US
dc.relation.volume81en_US
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.contributor.daisngid1545065-
dc.contributor.daisngid11410937-
dc.contributor.daisngid31444473-
dc.contributor.daisngid436538-
dc.contributor.daisngid4299213-
dc.contributor.daisngid4392829-
dc.contributor.daisngid10184652-
dc.contributor.daisngid2739554-
dc.contributor.daisngid233847-
dc.description.notasEmpresa: Biomar Iberia, S.A. A-63, Km. 99, Apdo. 16, 34210 Dueñas, Spain Ámbito de la empresa: Estatalen_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Torrecillas, S-
dc.contributor.wosstandardWOS:Rivero-Ramirez, F-
dc.contributor.wosstandardWOS:Izquierdo, MS-
dc.contributor.wosstandardWOS:Caballero, MJ-
dc.contributor.wosstandardWOS:Makol, A-
dc.contributor.wosstandardWOS:Suarez-Bregua, P-
dc.contributor.wosstandardWOS:Fernandez-Montero, A-
dc.contributor.wosstandardWOS:Rotllant, J-
dc.contributor.wosstandardWOS:Montero, D-
dc.date.coverdateOctubre 2018en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-BASen_US
dc.description.sjr1,04
dc.description.jcr3,298
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR Grupo de Investigación en Acuicultura-
crisitem.author.deptIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.deptDepartamento de Biología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR Grupo de Investigación en Acuicultura-
crisitem.author.deptIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.deptDepartamento de Biología-
crisitem.author.orcid0000-0003-4297-210X-
crisitem.author.orcid0000-0002-2575-0997-
crisitem.author.orcid0000-0002-4358-2157-
crisitem.author.parentorgIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.fullNameRivero Ramírez, Fernando Gustavo-
crisitem.author.fullNameIzquierdo López, María Soledad-
crisitem.author.fullNameCaballero Cansino, María José-
crisitem.author.fullNameMontero Vítores, Daniel-
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