Synthesis of natural phenylpropanoid esters via conventional chemical reactions

Abstract

Using classical reactions, the synthesis of seven natural esters was described, including for the first time the synthesis of four natural phenylpropanoid esters-compounds that have demonstrated promising bioactivity, proven by preliminary studies using samples obtained from natural sources. Applying the Wittig reaction, cis- and trans-bornyl ferulates were obtained, in an unusual manner, which established an alternative for the preparation of phenylpropanoid esters, especially in the synthesis of phenolic esters of tertiary alcohols such as the alpha-terpinyl trans-caffeate. The compounds obtained were identified and characterized by H-1-NMR and C-13-NMR spectroscopy.