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http://hdl.handle.net/10553/41510
Title: | Omega-3 LCPUFA supplementation improves neonatal and maternal bone turnover: A randomized controlled trial | Authors: | Kajarabille, Naroa Peña, Manuela Díaz-Castro, Javier Hurtado, Jose A. Peña Quintana, Luis Iznaola, Carmen Rodríguez-Santana, Yessica Martin-Alvarez, Estefanía López-Frias, Magdalena Lara-Villoslada, Federico Ochoa, Julio J. |
UNESCO Clasification: | 32 Ciencias médicas 320108 Ginecología |
Keywords: | Docosahexaenoicacid (DHA) Pregnancy Term neonates Bone turnover |
Issue Date: | 2018 | Journal: | Journal of Functional Foods | Abstract: | The aim of this study was to evaluate for the first time the effect of omega-3 LC PUFA supplementation during pregnancy and lactation on bone metabolism in mothers and neonates. 110 pregnant women were divided in two groups: control group (400 mL/day of the control dairy drink); supplemented group (400 mL/day of the fish oil-enriched dairy drink). Plasma bone biomarkers and mineral content in erythrocyte cytosol were assessed. In mothers, DHA supplementation increased OC and OPN levels and decreased IL-6 and TNF-α levels at delivery, increasing PTH levels during lactation. In neonates, DHA supplementation increased ACTH, insulin and leptin, decreasing RANKL and IL-6 in umbilical vein; increased OPG and leptin and diminished TNF-α in umbilical artery; increased OC levels, lowered PTH and TNF-α at birth. DHA supplementation during pregnancy and lactation has beneficial effects on bone turnover in both mother and neonates, representing a non-pharmacological pathway to decrease bone loss. | URI: | http://hdl.handle.net/10553/41510 | ISSN: | 1756-4646 | DOI: | 10.1016/j.jff.2018.04.065 | Source: | Journal of Functional Foods [ISSN 1756-4646], v. 46, p. 167-174 |
Appears in Collections: | Artículos |
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