Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/41314
Campo DC Valoridioma
dc.contributor.authorBoronat Cortés, Mauroen_US
dc.contributor.authorSantana-del-Pino, Angeloen_US
dc.contributor.authorBosch, Elviraen_US
dc.contributor.authorLorenzo, Dionisioen_US
dc.contributor.authorRiaño, Martaen_US
dc.contributor.authorGarcía-Cantón, Cesaren_US
dc.date.accessioned2018-06-19T07:58:49Z-
dc.date.available2018-06-19T07:58:49Z-
dc.date.issued2017en_US
dc.identifier.issn1660-8151en_US
dc.identifier.urihttp://hdl.handle.net/10553/41314-
dc.description.abstractBackground/Aims: Different biochemical abnormalities of metabolic bone disease have been associated with anemia of chronic kidney disease (CKD), mainly in hemodialysis patients. However, all of these abnormalities are closely interrelated and their individual effect on the development of anemia is uncertain. This study was aimed to assess the relationship between anemia and a set of metabolic bone disease biomarkers in a cohort of adult patients with advanced non-dialysis-dependent CKD. Methods: The sample consisted of 382 patients submitted to a Nephrology Unit for evaluation of advanced CKD in a tertiary hospital from Gran Canaria during 3 years. Associations between anemia and serum levels of calcium (albumin-corrected), phosphorus, PTH, 25-hydroxivitamin D (25(OH)D-3) and alkaline phosphatase were analyzed by using logistic regression models with adjustment for other demographic, clinical and biochemical covariates potentially related to anemia and to bone mineral metabolism. Results: Serum levels of calcium and 25(OH)D-3 (negatively) and phosphorus (positively) were significantly associated with anemia in an unadjusted logistic regression model. In a fully adjusted multivariable model, the OR for anemia was 0.29 (95\% CI 0.16-0.49; p < 0.0001) for every 1 mg/dl increase in serum calcium and 2.19 (95\% CI 1.55-3.15; p < 0.001) for every 1 mg/dl increase in serum phosphorus. Female sex and lower serum albumin levels were also independently associated with anemia. The inclusion of albumin in the adjusted model displaced the significance of 25(OH) D3. Conclusions: Circulating levels of calcium and phosphorus are strongly linked to anemia in patients with advanced non-dialysis CKD.en_US
dc.languageengen_US
dc.relation.ispartofNephronen_US
dc.sourceNephron [ISSN 1660-8151], v. 135 (2), p. 97-104en_US
dc.subject32 Ciencias médicasen_US
dc.subject120903 Análisis de datosen_US
dc.subject240401 Bioestadísticaen_US
dc.subject.otherAnemiaen_US
dc.subject.otherBone diseasesen_US
dc.subject.otherMetabolicen_US
dc.subject.otherCalciumen_US
dc.subject.otherPhosphorusen_US
dc.subject.otherRenal insufficiencyen_US
dc.subject.otherChronicen_US
dc.titleRelationship between anemia and serum concentrations of calcium and phosphorus in advanced non-dialysis-dependent chronic kidney diseaseen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1159/000450892
dc.identifier.scopus84991824739-
dc.identifier.isi000393634700002-
dc.contributor.authorscopusid7003952293
dc.contributor.authorscopusid56554207500
dc.contributor.authorscopusid36027905600
dc.contributor.authorscopusid55967938300
dc.contributor.authorscopusid37067926100
dc.contributor.authorscopusid6603127359
dc.identifier.eissn2235-3186-
dc.description.lastpage104-
dc.identifier.issue2-
dc.description.firstpage97-
dc.relation.volume135-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid673494
dc.contributor.daisngid2332689
dc.contributor.daisngid1780664
dc.contributor.daisngid30519221
dc.contributor.daisngid5257474
dc.contributor.daisngid1915819
dc.identifier.externalWOS:000393634700002-
dc.contributor.wosstandardWOS:Boronat, M
dc.contributor.wosstandardWOS:Santana, A
dc.contributor.wosstandardWOS:Bosch, E
dc.contributor.wosstandardWOS:Lorenzo, D
dc.contributor.wosstandardWOS:Riano, M
dc.contributor.wosstandardWOS:Garcia-Canton, C
dc.date.coverdateEnero 2017
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR Estadística-
crisitem.author.deptDepartamento de Matemáticas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0001-8535-8543-
crisitem.author.orcid0000-0002-6513-4814-
crisitem.author.orcid0000-0002-5988-8222-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgDepartamento de Matemáticas-
crisitem.author.fullNameBoronat Cortés, Mauro-
crisitem.author.fullNameSantana Del Pino, Ángelo-
crisitem.author.fullNameLorenzo Villegas, Dionisio Lorenzo-
crisitem.author.fullNameGarcía Cantón, César-
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