Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/37203
DC FieldValueLanguage
dc.contributor.authorRodriguez-Esparragon, Franciscoen_US
dc.contributor.authorLópez Fernández, Juan Carlosen_US
dc.contributor.authorBuset Ríos, Nisaen_US
dc.contributor.authorGarcía-Bello, Miguel Ángelen_US
dc.contributor.authorHernández-Velazquez, E.en_US
dc.contributor.authorCappiello, L.en_US
dc.contributor.authorRodriguez-Perez, Jose Carlosen_US
dc.contributor.otherRodriguez-Esparragon, Francisco
dc.contributor.otherGarcia-Bello, Miguel-Angel
dc.date.accessioned2018-06-04T07:47:08Z-
dc.date.available2018-06-04T07:47:08Z-
dc.date.issued2017en_US
dc.identifier.issn0020-7454en_US
dc.identifier.urihttp://hdl.handle.net/10553/37203-
dc.description.abstractPURPOSE OF THE STUDY: The present study aims to evaluate the relationship between rs662 (Gln(Q)192Arg(R)) and rs854560 (L55M) and the rs7493 (S311C) in the paraoxonase genes and ischemic stroke (IS) in the population of Gran Canaria (Canary Islands). The association with stroke was also evaluated using systematic review and meta-analysis. METHODS: A total of 129 IS patients and 176 age and gender matched controls were enrolled. For meta-analysis, eligible studies were identified through search in public databases. RESULTS: In multivariate regression analysis only the PON2 S311C variant showed to be an independent predictor of IS (OR = 0.093, 95% CI: 0.014–0.627). Overall, no significant association was found between L55M and IS when all studies were pooled nor by subgroup analysis by ethnicity. Gln192Arg showed a modest risk for IS in the global and in Asian population but with high heterogeneity among studies. A modest risk under a dominant inheritance model was found for the S311C variant with an overall random effect OR of 1.004 (95% CI: 1.00–1.35). There was strong evidence of heterogeneity among studies (p = 0.0097, I2 = 25.35%) which did not disappear after stratification by ethnicity. CONCLUSIONS: The overall analysis shows a significant contribution of the rs662 variant to IS risk. We found that the CC genotype of the PON2 S311C polymorphism is a risk factor for IS. Results of the meta-analysis partially support this conclusion.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.sourceInternational Journal Of Neuroscience[ISSN 0020-7454],v. 127 (3), p. 191-198en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherGeneticsen_US
dc.subject.otherParaoxonaseen_US
dc.subject.otherPolymorphismsen_US
dc.subject.otherStrokeen_US
dc.titleParaoxonase 1 and 2 gene variants and the ischemic stroke risk in Gran Canaria population: an association study and meta-analysisen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.3109/00207454.2016.1165675
dc.identifier.scopus84981284323-
dc.identifier.isi000393791300001
dcterms.isPartOfInternational Journal Of Neuroscience
dcterms.sourceInternational Journal Of Neuroscience[ISSN 0020-7454],v. 127 (3), p. 191-198
dc.contributor.authorscopusid6603262370
dc.contributor.authorscopusid23094644500
dc.contributor.authorscopusid34970818700
dc.contributor.authorscopusid36099016000
dc.contributor.authorscopusid55348741300
dc.contributor.authorscopusid57190578172
dc.contributor.authorscopusid7005446255
dc.description.lastpage198-
dc.identifier.issue3-
dc.description.firstpage191-
dc.relation.volume127-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000393791300001-
dc.contributor.daisngid1305938
dc.contributor.daisngid5219517
dc.contributor.daisngid2350741
dc.contributor.daisngid9299806
dc.contributor.daisngid1700450
dc.contributor.daisngid13637672
dc.contributor.daisngid5912276
dc.contributor.daisngid4337946
dc.identifier.investigatorRIDD-2810-2013
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Rodriguez-Esparragon, F
dc.contributor.wosstandardWOS:Lopez-Fernandez, JC
dc.contributor.wosstandardWOS:Buset-Rios, N
dc.contributor.wosstandardWOS:Garcia-Bello, MA
dc.contributor.wosstandardWOS:Hernandez-Velazquez, E
dc.contributor.wosstandardWOS:Cappiello, L
dc.contributor.wosstandardWOS:Rodriguez-Perez, JC
dc.date.coverdateMarzo 2017
dc.identifier.ulpgces
dc.description.sjr0,675
dc.description.jcr1,848
dc.description.sjrqQ2
dc.description.jcrqQ4
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-1663-3673-
crisitem.author.orcid0000-0003-0023-1063-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Esparragón,Francisco Javier-
crisitem.author.fullNameLópez Fernández, Juan Carlos-
crisitem.author.fullNameRodríguez Pérez, José Carlos-
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