Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/36024
Campo DC Valoridioma
dc.contributor.authorWang, Dong D.en_US
dc.contributor.authorToledo, Estefaniaen_US
dc.contributor.authorHruby, Adelaen_US
dc.contributor.authorRosner, Bernard A.en_US
dc.contributor.authorWillett, Walter C.en_US
dc.contributor.authorSun, Qien_US
dc.contributor.authorRazquin, Cristinaen_US
dc.contributor.authorZheng, Yanen_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorGuasch-Ferre, Martaen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorGomez-Gracia, Enriqueen_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorEstruch, Ramónen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorFito, Montseen_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorSerra-Majem, Lluisen_US
dc.contributor.authorLee, Chih-Haoen_US
dc.contributor.authorClish, Clary B.en_US
dc.contributor.authorLiang, Limingen_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorMartínez-González, Miguel Ángelen_US
dc.contributor.authorHu, Frank B.en_US
dc.date.accessioned2018-05-09T13:12:12Z-
dc.date.available2018-05-09T13:12:12Z-
dc.date.issued2017en_US
dc.identifier.issn0009-7322en_US
dc.identifier.urihttp://hdl.handle.net/10553/36024-
dc.description.abstractBACKGROUND: Although in vitro studies and investigations in animal models and small clinical populations have suggested that ceramides may represent an intermediate link between overnutrition and certain pathological mechanisms underlying cardiovascular disease (CVD), no prospective studies have investigated the association between plasma ceramides and risk of CVD. METHODS: The study population consisted of 980 participants from the PREDIMED trial (Prevencion con Dieta Mediterranea), including 230 incident cases of CVD and 787 randomly selected participants at baseline ( including 37 overlapping cases) followed for <= 7.4 years. Participants were randomized to a Mediterranean diet supplemented with extra virgin olive oil, a Mediterranean diet supplemented with nuts, or a control diet. Plasma ceramide concentrations were measured on a liquid chromatography tandem mass spectrometry metabolomics platform. The primary outcome was a composite of nonfatal acute myocardial infarction, nonfatal stroke, or cardiovascular death. Hazard ratios were estimated with weighted Cox regression models using Barlow weights to account for the case-cohort design. RESULTS: The multivariable hazard ratios (HR) and 95% confidence intervals (Cls) comparing the extreme quartiles of plasma concentrations of C16:0, C22:0, C24:0, and C24: 1 ceramides were 2.39 (1.49-3.83, P-trend < 0.001), 1.91 (1.21-3.01, P-trend = 0.003), 1.97 (1.21-3.20, P-trend = 0.004), and 1.73 (1.09-2.74, P-trend = 0.011), respectively. The ceramide score, calculated as a weighted sum of concentrations of four ceramides, was associated with a 2.18-fold higher risk of CVD across extreme quartiles (HR, 2.18; 95% Cl, 1.36-3.49; P-trend < 0.001). The association between baseline ceramide score and incident CVD varied significantly by treatment groups (P-interaction = 0.010). Participants with a higher ceramide score and assigned to either of the 2 active intervention arms of the trial showed similar CVD risk to those with a lower ceramide score, whereas participants with a higher ceramide score and assigned to the control arm presented significantly higher CVD risk. Changes in ceramide concentration were not significantly different between Mediterranean diet and control groups during the first year of follow-up. CONCLUSIONS: Our study documented a novel positive association between baseline plasma ceramide concentrations and incident CVD. In addition, a Mediterranean dietary intervention may mitigate potential deleterious effects of elevated plasma ceramide concentrations on CVD.en_US
dc.languageengen_US
dc.relation.ispartofCirculation (New York, N.Y.)en_US
dc.sourceCirculation [ISSN 0009-7322], v. 135 (21), p. 2028-2040en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherCardiovascular diseaseen_US
dc.subject.otherCeramideen_US
dc.subject.otherCoronary heart diseaseen_US
dc.subject.otherMediterraneandieten_US
dc.subject.otherStrokeen_US
dc.titlePlasma ceramides, Mediterranean diet, and incident cardiovascular disease in the PREDIMED Trial (Prevención con Dieta Mediterránea)en_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/CIRCULATIONAHA.116.024261
dc.identifier.scopus85018817364
dc.identifier.isi000401697500008-
dc.contributor.authorscopusid56351539800
dc.contributor.authorscopusid7003562288
dc.contributor.authorscopusid54939859200
dc.contributor.authorscopusid35396240300
dc.contributor.authorscopusid56803239300
dc.contributor.authorscopusid55245866000
dc.contributor.authorscopusid13612519200
dc.contributor.authorscopusid55762827700
dc.contributor.authorscopusid6603417884
dc.contributor.authorscopusid55110459200
dc.contributor.authorscopusid7003570538
dc.contributor.authorscopusid57202571697
dc.contributor.authorscopusid7005315313
dc.contributor.authorscopusid7005989830
dc.contributor.authorscopusid35474202600
dc.contributor.authorscopusid6507771144
dc.contributor.authorscopusid6602891390
dc.contributor.authorscopusid7004158382
dc.contributor.authorscopusid57202560799
dc.contributor.authorscopusid55700542500
dc.contributor.authorscopusid35460787900
dc.contributor.authorscopusid7202069545
dc.contributor.authorscopusid7003357665
dc.contributor.authorscopusid7004290629
dc.contributor.authorscopusid36038688700
dc.identifier.eissn1524-4539-
dc.identifier.issue21-
dc.relation.volume135-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000401697500008-
dc.contributor.daisngid1288250
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dc.contributor.daisngid276
dc.contributor.wosstandardWOS:Wang, DD
dc.contributor.wosstandardWOS:Toledo, E
dc.contributor.wosstandardWOS:Hruby, A
dc.contributor.wosstandardWOS:Rosner, BA
dc.contributor.wosstandardWOS:Willett, WC
dc.contributor.wosstandardWOS:Sun, Q
dc.contributor.wosstandardWOS:Razquin, C
dc.contributor.wosstandardWOS:Zheng, Y
dc.contributor.wosstandardWOS:Ruiz-Canela, M
dc.contributor.wosstandardWOS:Guasch-Ferre, M
dc.contributor.wosstandardWOS:Corella, D
dc.contributor.wosstandardWOS:Gomez-Gracia, E
dc.contributor.wosstandardWOS:Fiol, M
dc.contributor.wosstandardWOS:Estruch, R
dc.contributor.wosstandardWOS:Ros, E
dc.contributor.wosstandardWOS:Lapetra, J
dc.contributor.wosstandardWOS:Fito, M
dc.contributor.wosstandardWOS:Aros, F
dc.contributor.wosstandardWOS:Serra-Majem, L
dc.contributor.wosstandardWOS:Lee, CH
dc.contributor.wosstandardWOS:Clish, CB
dc.contributor.wosstandardWOS:Liang, LM
dc.contributor.wosstandardWOS:Salas-Salvado, J
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA
dc.contributor.wosstandardWOS:Hu, FB
dc.date.coverdateMayo 2017
dc.identifier.ulpgces
dc.description.sjr8,95
dc.description.jcr18,881
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-0898-5276-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameOcón Padrón, Ludmila-
crisitem.author.fullNameSerra Majem, Luis-
Colección:Artículos
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