Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/35733
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dc.contributor.authorYu, Edwarden_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorClish, Clary B.en_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorHruby, Adelaen_US
dc.contributor.authorFitó, Montseen_US
dc.contributor.authorLiang, Limingen_US
dc.contributor.authorToledo, Estefaníaen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorEstruch, Ramónen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorRomaguera, Doraen_US
dc.contributor.authorSerra-Majem, Lluisen_US
dc.contributor.authorGuasch-Ferré, Martaen_US
dc.contributor.authorWang, Dong D.en_US
dc.contributor.authorMartínez-González, Miguel Ángelen_US
dc.date.accessioned2018-05-07T09:41:12Z-
dc.date.available2018-05-07T09:41:12Z-
dc.date.issued2017en_US
dc.identifier.issn0021-972Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/35733-
dc.description.abstractContext: Arginine, its methylated metabolites, and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time. Objective: To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease (CVD) in a case-cohort setting. Design: A case-cohort study was nested within the Prevención con Dieta Mediterránea trial. We used liquid chromatography–tandem mass spectrometry to assess metabolite levels at baseline and after 1-year follow-up. The primary CVD outcome was a composite of myocardial infarction, stroke and cardiovascular death. We used weighted Cox regression models (Barlow weights) to estimate multivariable-adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs). Setting: Multicenter randomized trial in Spain. Participants: Participants were 984 participants accruing 231 events over 4.7 years’ median follow-up. Main Outcome Measure: Incident CVD. Results: Baseline arginine/asymmetric dimethylarginine ratio [HR per standard deviation (SD) = 0.80; 95% CI, 0.67 to 0.96] and global arginine availability [arginine / (ornithine + citrulline)] (HR per SD = 0.83; 95% CI, 0.69 to 1.00) were significantly associated with lower risk of CVD. We observed no significant association for 1-year changes in these ratios or any effect modification by the Mediterranean diet (MD) intervention. Conclusions: A higher baseline arginine/asymmetric dimethylarginine ratio was associated with lower CVD incidence in a high cardiovascular risk population. The intervention with the MD did not change 1-year levels of these metabolites.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_US
dc.sourceAustrian Journal of Clinical Endocrinology and Metabolism [ISSN 0021-972X], v. 102 (6), p. 1879-1888en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherCoronary-Heart-Disease
dc.subject.otherMediterranean-Style Diet
dc.subject.otherNitric-Oxide Synthase
dc.subject.otherL-Arginine Intake
dc.subject.otherRisk-Factors
dc.subject.otherAsymmetric Dimethylarginine
dc.subject.otherEndothelial Dysfunction
dc.subject.otherMetabolic Syndrome
dc.subject.otherRandomized-Trial
dc.subject.otherClinical-Trial
dc.titlePlasma arginine/asymmetric dimethylarginine ratio and incidence of cardiovascular events: a case-cohort studyen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticlees
dc.identifier.doi10.1210/jc.2016-3569
dc.identifier.scopus85020407381
dc.identifier.isi000403139100012-
dc.contributor.authorscopusid56660312400
dc.contributor.authorscopusid6603417884
dc.contributor.authorscopusid36038688700
dc.contributor.authorscopusid35460787900
dc.contributor.authorscopusid7003570538
dc.contributor.authorscopusid7003357665
dc.contributor.authorscopusid54939859200
dc.contributor.authorscopusid6602891390
dc.contributor.authorscopusid7202069545
dc.contributor.authorscopusid7003562288
dc.contributor.authorscopusid57202569537
dc.contributor.authorscopusid7005989830
dc.contributor.authorscopusid57202571697
dc.contributor.authorscopusid6507771144
dc.contributor.authorscopusid7004158382
dc.contributor.authorscopusid8161433300
dc.contributor.authorscopusid57202560799
dc.contributor.authorscopusid55110459200
dc.contributor.authorscopusid56351539800
dc.contributor.authorscopusid55664640000
dc.identifier.eissn1945-7197-
dc.description.lastpage1888-
dc.identifier.issue6-
dc.description.firstpage1879-
dc.relation.volume102-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid30357635
dc.contributor.daisngid31761100
dc.contributor.daisngid276
dc.contributor.daisngid84840
dc.contributor.daisngid25404
dc.contributor.daisngid25605
dc.contributor.daisngid861110
dc.contributor.daisngid74443
dc.contributor.daisngid11819816
dc.contributor.daisngid140645
dc.contributor.daisngid23007
dc.contributor.daisngid19357
dc.contributor.daisngid276771
dc.contributor.daisngid34937322
dc.contributor.daisngid106289
dc.contributor.daisngid232668
dc.contributor.daisngid28836
dc.contributor.daisngid854422
dc.contributor.daisngid1288250
dc.contributor.daisngid17754
dc.contributor.wosstandardWOS:Yu, E
dc.contributor.wosstandardWOS:Ruiz-Canela, M
dc.contributor.wosstandardWOS:Hu, FB
dc.contributor.wosstandardWOS:Clish, CB
dc.contributor.wosstandardWOS:Corella, D
dc.contributor.wosstandardWOS:Salas-Salvado, J
dc.contributor.wosstandardWOS:Hruby, A
dc.contributor.wosstandardWOS:Fito, M
dc.contributor.wosstandardWOS:Liang, L
dc.contributor.wosstandardWOS:Toledo, E
dc.contributor.wosstandardWOS:Ros, E
dc.contributor.wosstandardWOS:Estruch, R
dc.contributor.wosstandardWOS:Gomez-Gracia, E
dc.contributor.wosstandardWOS:Lapetra, J
dc.contributor.wosstandardWOS:Aros, F
dc.contributor.wosstandardWOS:Romaguera, D
dc.contributor.wosstandardWOS:Serra-Majem, L
dc.contributor.wosstandardWOS:Guasch-Ferre, M
dc.contributor.wosstandardWOS:Wang, DD
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA
dc.date.coverdateJunio 2017
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptNutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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