Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/35688
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dc.contributor.authorHernández Socorro, Carmen Rosaen_US
dc.contributor.authorJavier Rodriguez-Esparragon, Franciscoen_US
dc.contributor.authorCelli, Jenniferen_US
dc.contributor.authorLópez Fernández, Juan Carlosen_US
dc.contributor.otherRodriguez-Esparragon, Francisco
dc.date.accessioned2018-04-26T08:51:30Z-
dc.date.available2018-04-26T08:51:30Z-
dc.date.issued2017en_US
dc.identifier.issn0022-510Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/35688-
dc.description.abstractObjective: Common variants of the Paraoxonase (PON), 5-Methyl-Tetrahydrofolate-Reductase (MTHFR) and Angiotensin-II receptor 1 (AT1R) genes have been associated with ischemic stroke (IS) risk. Moreover, carotid atherosclerosis is a common cause of IS. The aim of this study is to explore whether variants in these genes associate with the severity of ultrasonographic determined atherosclerosis assessed in carotid arteries. Patients and methods: Etiologic subtype of cerebral ischemia was determined according to the TOAST classification. Genotypes were detected by PCR and restriction analysis. An ultrasonographic supra-aortic trunks study was performed to all patients to assess their atherosclerotic involvement based on predefined criteria. Results: In IS patients, none of the analyzed gene distributions differed concerning the stenosis degree. Nevertheless, a trend was observed for the rs662 and rs7493 variants of the PON1 and PON2 genes respectively. When evaluated the results based on different inheritance models, a significant contribution of rs7493 variant according to a dominant (or = 2.397, 95\% CI (1.001-5.376); p = 0.045) and log-additive inheritance forms (or = 1.85, 95\% CI (1.07-3.2); p = 0.03) was observed. only rs7493 reached statistical significance (p = 0.013), when genotype distribution was analyzed according to carotid intima-media thickness (cIMT) and remain significant in multivariate logistic regression analysis (or = 2.66, 95\% CI (1.1 to 6.4); p = 0.03). Conclusion: In IS patients of the north area of the Gran Canaria island the PON2 (rs7493) gene variant associates with a worse ultrasonographic profile. Conversely, the Cys311Cys homozygosis of the rs7493 variant was also related to a better ultrasonographic profile in our study.en_US
dc.languageengen_US
dc.relation.ispartofJournal of the Neurological Sciencesen_US
dc.sourceJournal Of The Neurological Sciences[ISSN 0022-510X],v. 378, p. 146-151en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherIschaemic strokeen_US
dc.subject.otherUltrasonographyen_US
dc.subject.otherCarotid intima-media thicknessen_US
dc.subject.otherGenotypesen_US
dc.subject.otherPolymorphismsen_US
dc.titleSonographic evaluation of atherosclerosis burden in carotid arteries of ischemic stroke patients and its relation to paraoxonase 1 and 2, MTHFR and AT1R genetic variantsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.jns.2017.05.010
dc.identifier.scopus85019091817
dc.identifier.isi000403997600032
dcterms.isPartOfJournal Of The Neurological Sciences
dcterms.sourceJournal Of The Neurological Sciences[ISSN 0022-510X],v. 378, p. 146-151
dc.contributor.authorscopusid6505758785
dc.contributor.authorscopusid6603262370
dc.contributor.authorscopusid57194194946
dc.contributor.authorscopusid23094644500
dc.identifier.eissn1878-5883-
dc.description.lastpage151-
dc.description.firstpage146-
dc.relation.volume378-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000403997600032-
dc.contributor.daisngid9999526
dc.contributor.daisngid1305938
dc.contributor.daisngid15572249
dc.contributor.daisngid2350741
dc.contributor.daisngid5219517
dc.identifier.investigatorRIDD-2810-2013
dc.contributor.wosstandardWOS:Hernandez-Socorro, CR
dc.contributor.wosstandardWOS:Rodriguez-Esparragon, FJ
dc.contributor.wosstandardWOS:Celli, J
dc.contributor.wosstandardWOS:Lopez-Fernandez, JC
dc.date.coverdateJulio 2017
dc.identifier.ulpgces
dc.description.sjr1,002
dc.description.jcr2,448
dc.description.sjrqQ2
dc.description.jcrqQ3
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Grupo de investigaciones infecciosas, nutricionales e inflamatorias en pacientes hospitalarios / Study Group on infectious, nutritional and inflammatory diseases in hospitalized patients-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-1663-3673-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameHernández Socorro, Carmen Rosa-
crisitem.author.fullNameRodríguez Esparragón,Francisco Javier-
crisitem.author.fullNameLópez Fernández, Juan Carlos-
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