Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/35367
DC FieldValueLanguage
dc.contributor.authorMorales-Alamo, Daviden_US
dc.contributor.authorGuerra, Borjaen_US
dc.contributor.authorPonce-González, Jesús Gustavoen_US
dc.contributor.authorGuadalupe Grau, Ameliaen_US
dc.contributor.authorSantana Rodríguez, Alfredoen_US
dc.contributor.authorMartin-Rincon, Marcosen_US
dc.contributor.authorGelabert-Rebato, Miriamen_US
dc.contributor.authorCadefau, Joan A.en_US
dc.contributor.authorCusso, Roseren_US
dc.contributor.authorDorado, Ceciliaen_US
dc.contributor.authorCalbet, Jose A. L.en_US
dc.contributor.otherGuerra, Borja-
dc.contributor.otherPonce Gonzalez, Jesus Gustavo-
dc.contributor.otherCadefau, Joan AurelI-
dc.contributor.otherCalbet, Jose A-
dc.contributor.otherMorales-Alamo, David-
dc.contributor.otherDorado Garcia, Cecilia-
dc.contributor.otherMartin-Rincon, Marcos-
dc.date.accessioned2018-04-13T09:56:20Z-
dc.date.available2018-04-13T09:56:20Z-
dc.date.issued2017en_US
dc.identifier.issn8750-7587en_US
dc.identifier.urihttp://hdl.handle.net/10553/35367-
dc.description.abstractThe aim of this study was to determine if reactive oxygen species (ROS) could play a role in blunting Thr172-AMP-activated protein kinase (AMPK)-α phosphorylation in human skeletal muscle after sprint exercise in hypoxia and to elucidate the potential signaling mechanisms responsible for this response. Nine volunteers performed a single 30-s sprint (Wingate test) in two occasions while breathing hypoxic gas (PIO2 = 75 mmHg): one after the ingestion of placebo and another following the intake of antioxidants (-lipoic acid, vitamin C, and vitamin E), with a randomized double-blind design. Vastus lateralis muscle biopsies were obtained before, immediately after, and 30- and 120-min postsprint. Compared with the control condition, the ingestion of antioxidants resulted in lower plasma carbonylated proteins, attenuated elevation of the AMP-to-ATP molar ratio, and reduced glycolytic rate (P < 0.05) without significant effects on performance or V ? O2. The ingestion of antioxidants did not alter the basal muscle signaling. Thr172-AMPK- and Thr184/187-transforming growth factor-activated kinase 1 (TAK1) phosphorylation were not increased after the sprint regardless of the ingestion of antioxidants. Thr286-CaMKII phosphorylation was increased after the sprint, but this response was blunted by the antioxidants. Ser485-AMPKα1/Ser491-AMPKα2 phosphorylation increased immediately after the sprints coincident with increased Akt phosphorylation. In summary, antioxidants attenuate the glycolytic response to sprint exercise in severe acute hypoxia and modify the muscle signaling response to exercise. Ser485-AMPK α 1/Ser491-AMPKα2 phosphorylation, a known mechanism of Thr172- AMPKα phosphorylation inhibition, is increased immediately after sprint exercise in hypoxia, probably by a mechanism independent of ROS.en_US
dc.languageengen_US
dc.relationIntegracion de Los Grupos de la Obesidad y El Síndrome Metabólico ....en_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.sourceJournal Of Applied Physiology[ISSN 8750-7587],v. 123 (5), p. 1235-1245en_US
dc.subject241106 Fisiología del ejercicioen_US
dc.subject.otherSprint exerciseen_US
dc.subject.otherSkeletal muscleen_US
dc.subject.otherHypoxiaen_US
dc.subject.otherHumanen_US
dc.subject.otherAdenosine5'-monophosphate-activated protein kinaseen_US
dc.subject.otherOxidative stressen_US
dc.titleSkeletal muscle signaling, metabolism, and performance during sprint exercise in severe acute hypoxia after the ingestion of antioxidantsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1152/japplphysiol.00384.2017en_US
dc.identifier.scopus85032454438-
dc.identifier.isi000416597900024-
dcterms.isPartOfJournal Of Applied Physiology-
dcterms.sourceJournal Of Applied Physiology[ISSN 8750-7587],v. 123 (5), p. 1235-1245-
dc.contributor.authorscopusid35148038500-
dc.contributor.authorscopusid7006442271-
dc.contributor.authorscopusid25628359100-
dc.contributor.authorscopusid25627673000-
dc.contributor.authorscopusid55617275900-
dc.contributor.authorscopusid56841673800-
dc.contributor.authorscopusid57191612961-
dc.contributor.authorscopusid6701774431-
dc.contributor.authorscopusid7003697822-
dc.contributor.authorscopusid6602610320-
dc.contributor.authorscopusid7004323423-
dc.identifier.eissn1522-1601-
dc.description.lastpage1245en_US
dc.identifier.issue5-
dc.description.firstpage1235en_US
dc.relation.volume123en_US
dc.investigacionCiencias Sociales y Jurídicasen_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000416597900024-
dc.contributor.daisngid1232764-
dc.contributor.daisngid909211-
dc.contributor.daisngid1264657-
dc.contributor.daisngid12239588-
dc.contributor.daisngid861361-
dc.contributor.daisngid3572788-
dc.contributor.daisngid1230811-
dc.contributor.daisngid31470516-
dc.contributor.daisngid3057600-
dc.contributor.daisngid7914106-
dc.contributor.daisngid30797370-
dc.contributor.daisngid985507-
dc.contributor.daisngid496197-
dc.contributor.daisngid629383-
dc.contributor.daisngid90295-
dc.identifier.investigatorRIDG-9739-2015-
dc.identifier.investigatorRIDH-9500-2015-
dc.identifier.investigatorRIDM-7934-2018-
dc.identifier.investigatorRIDH-6693-2015-
dc.identifier.investigatorRIDD-2683-2009-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Morales-Alamo, D-
dc.contributor.wosstandardWOS:Guerra, B-
dc.contributor.wosstandardWOS:Ponce-Gonzalez, JG-
dc.contributor.wosstandardWOS:Guadalupe-Grau, A-
dc.contributor.wosstandardWOS:Santana, A-
dc.contributor.wosstandardWOS:Martin-Rincon, M-
dc.contributor.wosstandardWOS:Gelabert-Rebato, M-
dc.contributor.wosstandardWOS:Cadefau, JA-
dc.contributor.wosstandardWOS:Cusso, R-
dc.contributor.wosstandardWOS:Dorado, C-
dc.contributor.wosstandardWOS:Calbet, JAL-
dc.date.coverdateNoviembre 2017en_US
dc.identifier.ulpgces
dc.description.sjr1,471
dc.description.jcr3,256
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0001-8463-397X-
crisitem.author.orcid0000-0003-4355-5682-
crisitem.author.orcid0000-0002-3685-2331-
crisitem.author.orcid0000-0001-6616-6810-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMorales Álamo, David-
crisitem.author.fullNameGuerra Hernández, Carlos Borja-
crisitem.author.fullNameGuadalupe Grau,Amelia-
crisitem.author.fullNameSantana Rodríguez, Alfredo-
crisitem.author.fullNameMartín Rincón, Marcos-
crisitem.author.fullNameGelaber Rebato,Miriam-
crisitem.author.fullNameDorado García, Cecilia-
crisitem.author.fullNameLópez Calbet, José Antonio-
crisitem.project.principalinvestigatorReal Valcárcel, Fernando-
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