Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/35367
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Morales-Alamo, David | en_US |
dc.contributor.author | Guerra, Borja | en_US |
dc.contributor.author | Ponce-González, Jesús Gustavo | en_US |
dc.contributor.author | Guadalupe Grau, Amelia | en_US |
dc.contributor.author | Santana Rodríguez, Alfredo | en_US |
dc.contributor.author | Martin-Rincon, Marcos | en_US |
dc.contributor.author | Gelabert-Rebato, Miriam | en_US |
dc.contributor.author | Cadefau, Joan A. | en_US |
dc.contributor.author | Cusso, Roser | en_US |
dc.contributor.author | Dorado, Cecilia | en_US |
dc.contributor.author | Calbet, Jose A. L. | en_US |
dc.contributor.other | Guerra, Borja | - |
dc.contributor.other | Ponce Gonzalez, Jesus Gustavo | - |
dc.contributor.other | Cadefau, Joan AurelI | - |
dc.contributor.other | Calbet, Jose A | - |
dc.contributor.other | Morales-Alamo, David | - |
dc.contributor.other | Dorado Garcia, Cecilia | - |
dc.contributor.other | Martin-Rincon, Marcos | - |
dc.date.accessioned | 2018-04-13T09:56:20Z | - |
dc.date.available | 2018-04-13T09:56:20Z | - |
dc.date.issued | 2017 | en_US |
dc.identifier.issn | 8750-7587 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/35367 | - |
dc.description.abstract | The aim of this study was to determine if reactive oxygen species (ROS) could play a role in blunting Thr172-AMP-activated protein kinase (AMPK)-α phosphorylation in human skeletal muscle after sprint exercise in hypoxia and to elucidate the potential signaling mechanisms responsible for this response. Nine volunteers performed a single 30-s sprint (Wingate test) in two occasions while breathing hypoxic gas (PIO2 = 75 mmHg): one after the ingestion of placebo and another following the intake of antioxidants (-lipoic acid, vitamin C, and vitamin E), with a randomized double-blind design. Vastus lateralis muscle biopsies were obtained before, immediately after, and 30- and 120-min postsprint. Compared with the control condition, the ingestion of antioxidants resulted in lower plasma carbonylated proteins, attenuated elevation of the AMP-to-ATP molar ratio, and reduced glycolytic rate (P < 0.05) without significant effects on performance or V ? O2. The ingestion of antioxidants did not alter the basal muscle signaling. Thr172-AMPK- and Thr184/187-transforming growth factor-activated kinase 1 (TAK1) phosphorylation were not increased after the sprint regardless of the ingestion of antioxidants. Thr286-CaMKII phosphorylation was increased after the sprint, but this response was blunted by the antioxidants. Ser485-AMPKα1/Ser491-AMPKα2 phosphorylation increased immediately after the sprints coincident with increased Akt phosphorylation. In summary, antioxidants attenuate the glycolytic response to sprint exercise in severe acute hypoxia and modify the muscle signaling response to exercise. Ser485-AMPK α 1/Ser491-AMPKα2 phosphorylation, a known mechanism of Thr172- AMPKα phosphorylation inhibition, is increased immediately after sprint exercise in hypoxia, probably by a mechanism independent of ROS. | en_US |
dc.language | eng | en_US |
dc.relation | Integracion de Los Grupos de la Obesidad y El Síndrome Metabólico .... | en_US |
dc.relation.ispartof | Journal of Applied Physiology | en_US |
dc.source | Journal Of Applied Physiology[ISSN 8750-7587],v. 123 (5), p. 1235-1245 | en_US |
dc.subject | 241106 Fisiología del ejercicio | en_US |
dc.subject.other | Sprint exercise | en_US |
dc.subject.other | Skeletal muscle | en_US |
dc.subject.other | Hypoxia | en_US |
dc.subject.other | Human | en_US |
dc.subject.other | Adenosine5'-monophosphate-activated protein kinase | en_US |
dc.subject.other | Oxidative stress | en_US |
dc.title | Skeletal muscle signaling, metabolism, and performance during sprint exercise in severe acute hypoxia after the ingestion of antioxidants | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1152/japplphysiol.00384.2017 | en_US |
dc.identifier.scopus | 85032454438 | - |
dc.identifier.isi | 000416597900024 | - |
dcterms.isPartOf | Journal Of Applied Physiology | - |
dcterms.source | Journal Of Applied Physiology[ISSN 8750-7587],v. 123 (5), p. 1235-1245 | - |
dc.contributor.authorscopusid | 35148038500 | - |
dc.contributor.authorscopusid | 7006442271 | - |
dc.contributor.authorscopusid | 25628359100 | - |
dc.contributor.authorscopusid | 25627673000 | - |
dc.contributor.authorscopusid | 55617275900 | - |
dc.contributor.authorscopusid | 56841673800 | - |
dc.contributor.authorscopusid | 57191612961 | - |
dc.contributor.authorscopusid | 6701774431 | - |
dc.contributor.authorscopusid | 7003697822 | - |
dc.contributor.authorscopusid | 6602610320 | - |
dc.contributor.authorscopusid | 7004323423 | - |
dc.identifier.eissn | 1522-1601 | - |
dc.description.lastpage | 1245 | en_US |
dc.identifier.issue | 5 | - |
dc.description.firstpage | 1235 | en_US |
dc.relation.volume | 123 | en_US |
dc.investigacion | Ciencias Sociales y Jurídicas | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000416597900024 | - |
dc.contributor.daisngid | 1232764 | - |
dc.contributor.daisngid | 909211 | - |
dc.contributor.daisngid | 1264657 | - |
dc.contributor.daisngid | 12239588 | - |
dc.contributor.daisngid | 861361 | - |
dc.contributor.daisngid | 3572788 | - |
dc.contributor.daisngid | 1230811 | - |
dc.contributor.daisngid | 31470516 | - |
dc.contributor.daisngid | 3057600 | - |
dc.contributor.daisngid | 7914106 | - |
dc.contributor.daisngid | 30797370 | - |
dc.contributor.daisngid | 985507 | - |
dc.contributor.daisngid | 496197 | - |
dc.contributor.daisngid | 629383 | - |
dc.contributor.daisngid | 90295 | - |
dc.identifier.investigatorRID | G-9739-2015 | - |
dc.identifier.investigatorRID | H-9500-2015 | - |
dc.identifier.investigatorRID | M-7934-2018 | - |
dc.identifier.investigatorRID | H-6693-2015 | - |
dc.identifier.investigatorRID | D-2683-2009 | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.contributor.wosstandard | WOS:Morales-Alamo, D | - |
dc.contributor.wosstandard | WOS:Guerra, B | - |
dc.contributor.wosstandard | WOS:Ponce-Gonzalez, JG | - |
dc.contributor.wosstandard | WOS:Guadalupe-Grau, A | - |
dc.contributor.wosstandard | WOS:Santana, A | - |
dc.contributor.wosstandard | WOS:Martin-Rincon, M | - |
dc.contributor.wosstandard | WOS:Gelabert-Rebato, M | - |
dc.contributor.wosstandard | WOS:Cadefau, JA | - |
dc.contributor.wosstandard | WOS:Cusso, R | - |
dc.contributor.wosstandard | WOS:Dorado, C | - |
dc.contributor.wosstandard | WOS:Calbet, JAL | - |
dc.date.coverdate | Noviembre 2017 | en_US |
dc.identifier.ulpgc | Sí | es |
dc.description.sjr | 1,471 | |
dc.description.jcr | 3,256 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.project.principalinvestigator | Real Valcárcel, Fernando | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.orcid | 0000-0001-8463-397X | - |
crisitem.author.orcid | 0000-0003-4355-5682 | - |
crisitem.author.orcid | 000-0002-1075-9948 | - |
crisitem.author.orcid | 0000-0002-3685-2331 | - |
crisitem.author.orcid | 0000-0001-6616-6810 | - |
crisitem.author.orcid | 0000-0002-9215-6234 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Morales Álamo, David | - |
crisitem.author.fullName | Guerra Hernández, Carlos Borja | - |
crisitem.author.fullName | Guadalupe Grau,Amelia | - |
crisitem.author.fullName | Santana Rodríguez, Alfredo | - |
crisitem.author.fullName | Martín Rincón, Marcos | - |
crisitem.author.fullName | Gelaber Rebato,Miriam | - |
crisitem.author.fullName | Dorado García, Cecilia | - |
crisitem.author.fullName | López Calbet, José Antonio | - |
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