Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/33737
DC FieldValueLanguage
dc.contributor.authorSantana Viera, Sergioen_US
dc.contributor.authorGuedes-Alonso, Raycoen_US
dc.contributor.authorSosa-Ferrera Z.en_US
dc.contributor.authorSantana-Rodríguez, José Juanen_US
dc.contributor.authorKabir, Abuzaren_US
dc.contributor.authorFurton, Kenneth G.en_US
dc.date.accessioned2018-03-13T10:30:07Z-
dc.date.available2018-03-13T10:30:07Z-
dc.date.issued2017en_US
dc.identifier.issn0021-9673en_US
dc.identifier.urihttp://hdl.handle.net/10553/35321-
dc.description.abstractEvery year, hundreds of tons of organic pollutants reach the environment through effluents released from wastewater treatment plants worldwide, and many of these compounds have harmful effects on the aquatic ecosystem. A new class of emerging pollutants of high concern is cytostatic drugs, which are designed to treat different types of cancers by attacking cells. Environmental concentrations of cytostatic drugs are known to be in the range of ng L −1 , and for this reason, it is imperative to develop analytical methods of extraction and preconcentration to allow for subsequent instrumental analysis of these drugs. In this work, a rapid, simple and green method for the analysis of seven cytostatic drug compounds that are commonly used in anti-cancer therapies was developed using a novel extraction process based on a powerful miniaturized technique, fabric phase sorptive extraction (FPSE) coupled to ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS). The major parameters that affect the extraction process were optimized. The new method shows good linearity, with a relative standard deviation (RSD) of less than 12%. Relative recoveries higher than 40% were obtained for the studied compounds, and the detection limit of the method was within the values at which these compounds are usually found in environmental water (0.20 ng L −1 to 80 ng L −1 ). The Limit of Quantification ranged from 0.68 to 267 ng L −1 . Significant suppression of the signal due to the matrix effect, a common shortcoming attributed to interference from the extraction process as well as the use of ionization mode, was not observed. Subsequently, the method was applied to real wastewater samples from an effluent obtained from a hospital area and three wastewater treatment plants located in Gran Canaria Island, Spain.-
dc.languageengen_US
dc.relation.ispartofJournal of Chromatography Aen_US
dc.sourceJournal of Chromatography A [ISSN 0021-9673], v. 1529, p. 39-49en_US
dc.subject2301 química analítica-
dc.subject230103 Análisis cromatográfico-
dc.subject330810 Tecnología de aguas residuales-
dc.subject251002 Oceanografía química-
dc.subject.otherCytostatic compounds-
dc.subject.otherDrug residues-
dc.subject.otherEmerging pollutants-
dc.subject.otherFabric phase sorptive extraction-
dc.subject.otherUltra-high performance liquid chromatography-
dc.subject.otherWastewater-
dc.titleOptimization and application of fabric phase sorptive extraction coupled to ultra-high performance liquid chromatography tandem mass spectrometry for the determination of cytostatic drug residues in environmental watersen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.pmid1529-
dc.identifier.scopus2-s2.0-85033582549-
dc.identifier.urlhttp://api.elsevier.com/content/abstract/scopus_id/85033582549-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.identifier.eissn1873-3778-
dc.description.lastpage49-
dc.description.firstpage39-
dc.relation.volume1529-
dc.investigacionCiencias-
dc.source.typear-
dc.type2Artículoen_US
dc.identifier.ulpgces
dc.description.sjr1,378
dc.description.jcr3,716
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.orcid0000-0002-2412-0037-
crisitem.author.orcid0000-0002-9189-9589-
crisitem.author.orcid0000-0003-3003-3607-
crisitem.author.orcid0000-0002-5635-7215-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.fullNameSantana Viera, Sergio-
crisitem.author.fullNameGuedes Alonso, Raico Iván-
crisitem.author.fullNameSosa Ferrera, María Zoraida-
crisitem.author.fullNameSantana Rodríguez, José Juan-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

22
checked on Jul 21, 2024

Page view(s)

72
checked on Jun 15, 2024

Google ScholarTM

Check


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.