Association of the european lactase persistence variant (LCT-13910 C>T polymorphism) with obesity in the Canary Islands

Abstract

European lactose tolerance genotype (LCT -13910 C.T, rs4988234) has been positively associated to body mass indexes (BMI) in a meta-analysis of 31,720 individuals of northern and central European descent. A strong association of lactase persistence (LP) with BMI and obesity has also been traced in a Spanish Mediterranean population. The aim of this study was to analyze a potential association of LP compared to lactase non-persistence (LNP) with BMI in inhabitants of the Canary Islands of Spain using Mendelian randomization