Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/21070
Campo DC Valoridioma
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorOrtega-Azorín, Carolinaen_US
dc.contributor.authorSorlí, José V.en_US
dc.contributor.authorCovas, María Isabelen_US
dc.contributor.authorCarrasco, Paulaen_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorMartínez-González, Miguel Ángelen_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorSerra-Majem, Lluisen_US
dc.contributor.authorLamuela-Raventós, R.M.en_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorPinto, Xavieren_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorMartí, Ameliaen_US
dc.contributor.authorColtell, Oscaren_US
dc.contributor.authorColtell, Oscaren_US
dc.contributor.authorOrdovás, José M.en_US
dc.contributor.authorEstruch, Ramónen_US
dc.date.accessioned2017-03-24T03:30:42Z-
dc.date.accessioned2018-03-15T14:37:29Z-
dc.date.available2017-03-24T03:30:42Z-
dc.date.available2018-03-15T14:37:29Z-
dc.date.issued2012en_US
dc.identifier.issn1932-6203en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/21070-
dc.description.abstractBackground: Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. Objective: To investigate whether MC4R and FTO associations with body-weight are modulated by diet and physical activity (PA), and to study their association with alcohol and food intake. Methods: Adherence to Mediterranean diet (AdMedDiet) and physical activity (PA) were assessed by validated questionnaires in 7,052 high cardiovascular risk subjects. MC4R rs17782313 and FTO rs9939609 were determined. Independent and joint associations (aggregate genetic score) as well as statistical and biological gene-lifestyle interactions were analyzed. Results: FTO rs9939609 was associated with higher body mass index (BMI), waist circumference (WC) and obesity (P<0.05 for all). A similar, but not significant trend was found for MC4R rs17782313. Their additive effects (aggregate score) were significant and we observed a 7% per-allele increase of being obese (OR=1.07; 95%CI 1.01-1.13). We found relevant statistical interactions (P<0.05) with PA. So, in active individuals, the associations with higher BMI, WC or obesity were not detected. A biological (non-statistical) interaction between AdMedDiet and rs9939609 and the aggregate score was found. Greater AdMedDiet in individuals carrying 4 or 3-risk alleles counterbalanced their genetic predisposition, exhibiting similar BMI (P=0.502) than individuals with no risk alleles and lower AdMedDiet. They also had lower BMI (P=0.021) than their counterparts with low AdMedDiet. We did not find any consistent association with energy or macronutrients, but found a novel association between these polymorphisms and lower alcohol consumption in variant-allele carriers (B+/-SE: -0.57+/-0.16 g/d per-score-allele; P=0.001). Conclusion: Statistical and biological interactions with PA and diet modulate the effects of FTO and MC4R polymorphisms on obesity. The novel association with alcohol consumption seems independent of their effects on BMI.en_US
dc.formatapplication/pdf-
dc.languageengen_US
dc.relationRed Alimentación Saludable en la Prevención Primaria de Enfermedades Crónicas: la Red Predimed. (Retics 2006)en_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsby-nc-nd-
dc.sourcePLoS ONE [ISSN 1932-6203], v. 7(12)en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherMediterranean dieten_US
dc.subject.otherLifestyleen_US
dc.subject.otherDieten_US
dc.subject.otherPhysical activityen_US
dc.subject.otherObesityen_US
dc.subject.otherAlcohol consumptionen_US
dc.titleStatistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumptionen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0052344en_US
dc.identifier.scopus2-s2.0-84871356839-
dc.identifier.isi000313158800050-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid21835135600-
dc.contributor.authorscopusid7004605575-
dc.contributor.authorscopusid35519153600-
dc.contributor.authorscopusid35739810600-
dc.contributor.authorscopusid7003357665-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid7004158382-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid7003644939-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid7005315313-
dc.contributor.authorscopusid7004430064-
dc.contributor.authorscopusid35474202600-
dc.contributor.authorscopusid7102814881-
dc.contributor.authorscopusid6603090571-
dc.contributor.authorscopusid7101791147-
dc.contributor.authorscopusid7005989830-
dc.identifier.crisid-;-;-;-;-;-;-;-;-;2693;-;-;-;-;-;-;-;7271;-;--
dc.identifier.eissn1932-6203-
dc.identifier.issue12-
dc.relation.volume7en_US
dc.investigacionCiencias de la Saluden_US
dc.project.referenceRTIC G03/140; RD 06/0045; PI04-2239; PI 05/2584; CP06/00100; PI07/0240; PI07/1138; PI07/0954; PI07/0473; PI10/01407; PI11/02505; PI11/01647; CNIC-06; AGL2010-22319-C03-0; AP-042/11; BEST11-26-
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess-
dc.type2Artículoen_US
dc.contributor.daisngid25404-
dc.contributor.daisngid1237216-
dc.contributor.daisngid495748-
dc.contributor.daisngid97840-
dc.contributor.daisngid650144-
dc.contributor.daisngid25605-
dc.contributor.daisngid17754-
dc.contributor.daisngid106289-
dc.contributor.daisngid246378-
dc.contributor.daisngid28836-
dc.contributor.daisngid124880-
dc.contributor.daisngid276771-
dc.contributor.daisngid78038-
dc.contributor.daisngid115192-
dc.contributor.daisngid23007-
dc.contributor.daisngid70939-
dc.contributor.daisngid441770-
dc.contributor.daisngid1564-
dc.contributor.daisngid19357-
dc.identifier.external-;-;-;-;-;-;-;-;-;2693;-;-;-;-;-;-;-;7271;-;--
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Ortega-Azorin, C-
dc.contributor.wosstandardWOS:Sorli, JV-
dc.contributor.wosstandardWOS:Covas, MI-
dc.contributor.wosstandardWOS:Carrasco, P-
dc.contributor.wosstandardWOS:Salas-Salvado, J-
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA-
dc.contributor.wosstandardWOS:Aros, F-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Serra-Majem, L-
dc.contributor.wosstandardWOS:Lamuela-Raventos, R-
dc.contributor.wosstandardWOS:Gomez-Gracia, E-
dc.contributor.wosstandardWOS:Fiol, M-
dc.contributor.wosstandardWOS:Pinto, X-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Marti, A-
dc.contributor.wosstandardWOS:Coltell, O-
dc.contributor.wosstandardWOS:Ordovas, JM-
dc.contributor.wosstandardWOS:Estruch, R-
dc.date.coverdateDiciembre 2012en_US
dc.identifier.supplement-;-;-;-;-;-;-;-;-;2693;-;-;-;-;-;-;-;7271;-;--
dc.identifier.supplement-;-;-;-;-;-;-;-;-;2693;-;-;-;-;-;-;-;7271;-;--
dc.identifier.supplement-;-;-;-;-;-;-;-;-;2693;-;-;-;-;-;-;-;7271;-;--
dc.identifier.supplement-;-;-;-;-;-;-;-;-;2693;-;-;-;-;-;-;-;7271;-;--
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,945
dc.description.jcr3,73
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.erihplusERIH PLUS
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.project.principalinvestigatorSerra Majem, Luis-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
Colección:Artículos
miniatura
Adobe PDF (452,12 kB)
Vista resumida

Citas SCOPUSTM   

60
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

47
actualizado el 20-feb-2022

Visitas

78
actualizado el 19-ago-2023

Descargas

137
actualizado el 19-ago-2023

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.