Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/21027
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Fernández-Pérez, Leandro | en_US |
dc.contributor.author | Guerra, Borja | en_US |
dc.contributor.author | Díaz-Chico, Juan C. | en_US |
dc.contributor.author | Flores-Morales, A. | en_US |
dc.date.accessioned | 2017-03-22T03:30:18Z | - |
dc.date.accessioned | 2018-03-16T09:14:07Z | - |
dc.date.available | 2017-03-22T03:30:18Z | - |
dc.date.available | 2018-03-16T09:14:07Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.issn | 1664-2392 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/21027 | - |
dc.description.abstract | The liver responds to estrogens and growth hormone (GH) which are critical regulators of body growth, gender-related hepatic functions, and intermediate metabolism. The effects of estrogens on liver can be direct, through the direct actions of hepatic ER, or indirect, which include the crosstalk with endocrine, metabolic, and sex-differentiated functions of GH. Most previous studies have been focused on the influence of estrogens on pituitary GH secretion, which has a great impact on hepatic transcriptional regulation. However, there is strong evidence that estrogens can influence the GH-regulated endocrine and metabolic functions in the human liver by acting at the level of GHR-STAT5 signaling pathway. This crosstalk is relevant because the widespread exposition of estrogen or estrogen-related compounds in human. Therefore, GH or estrogen signaling deficiency as well as the influence of estrogens on GH biology can cause a dramatic impact in liver physiology during mammalian development and in adulthood. In this review, we will summarize the current status of the influence of estrogen on GH actions in liver. A better understanding of estrogen-GH interplay in liver will lead to improved therapy of children with growth disorders and of adults with GH deficiency. © 2013 Fernández-Pérez, Guerra, Díaz-Chico and Flores-Morales. | en_US |
dc.format | application/pdf | es |
dc.language | eng | en_US |
dc.relation.ispartof | Frontiers in Endocrinology | en_US |
dc.rights | by-nc-nd | es |
dc.source | Frontiers in Endocrinology [ISSN 1664-2392], v. 4 (66) | en_US |
dc.subject | 320502 Endocrinología | en_US |
dc.subject.other | Growth hormone | en_US |
dc.subject.other | Estrogen | en_US |
dc.subject.other | Liver | en_US |
dc.subject.other | Metabolism | en_US |
dc.subject.other | Sexual dimorphism | en_US |
dc.title | Estrogens regulate the hepatic effects of growth hormone, a hormonal interplay with multiple fates | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3389/fendo.2013.00066 | en_US |
dc.identifier.scopus | 84884190294 | - |
dc.contributor.authorscopusid | 6506777525 | - |
dc.contributor.authorscopusid | 7006442271 | - |
dc.contributor.authorscopusid | 6701492347 | - |
dc.contributor.authorscopusid | 57203543352 | - |
dc.identifier.crisid | 2167;20507;1996;- | - |
dc.relation.volume | 4 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.rights.accessrights | Acceso libre | es |
dc.type2 | Artículo | en_US |
dc.utils.revision | Sí | en_US |
dc.date.coverdate | Septiembre 2013 | en_US |
dc.identifier.supplement | 2167;20507;1996;- | - |
dc.identifier.supplement | 2167;20507;1996;- | - |
dc.identifier.supplement | 2167;20507;1996;- | - |
dc.identifier.supplement | 2167;20507;1996;- | - |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.scie | SCIE | |
item.fulltext | Con texto completo | - |
item.grantfulltext | open | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.orcid | 0000-0001-7802-465X | - |
crisitem.author.orcid | 0000-0003-4355-5682 | - |
crisitem.author.orcid | 0000-0002-0944-990X | - |
crisitem.author.orcid | 0000-0002-0828-8921 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Fernández Pérez, Leandro Francisco | - |
crisitem.author.fullName | Guerra Hernández, Carlos Borja | - |
crisitem.author.fullName | Díaz Chico, Juan Carlos | - |
crisitem.author.fullName | Flores Morales,Amilcar | - |
Colección: | Artículos |
Citas SCOPUSTM
33
actualizado el 08-sep-2024
Visitas
119
actualizado el 10-ago-2024
Descargas
137
actualizado el 10-ago-2024
Google ScholarTM
Verifica
Altmetric
Comparte
Exporta metadatos
Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.