Identifying Cell-Type-Specific Alterations Underlying Schizophrenia-Related EEG Deficits Using a Multi-scale Model of Auditory Thalamocortical Circuits

Abstract

Schizophrenia is associated with cognitive deficits, including disruptions in sensory processing. Electroencephalography (EEG) studies have identified abnormalities in event-related potentials and cortical oscillations, particularly within the auditory system. Among the most wellestablished EEG biomarkers are the reduced 40 Hz Auditory Steady-State Response (ASSR) and impaired mismatch negativity (MMN). Understanding the neural mechanisms underlying these EEG deficits is critical for linking molecular and circuit-level alterations to cognitive dysfunctions in schizophrenia.