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| Title: | Host Genetic Factors in Q Fever Susceptibility | Authors: | Pérez Arellano, José Luis Montes-Ares, Olga Torio-Ruiz, Alberto Hernández Cabrera, Pilar Michele Pisos Álamo, Elena Carranza Rodríguez, Cristina Robaina Bordón, José María |
UNESCO Clasification: | 32 Ciencias médicas 3207 Patología |
Keywords: | Immune-Response Genes Coxiella-Burnetii Polymorphisms <Italic>Coxiella Burnetii</Italic> Q Fever, et al |
Issue Date: | 2025 | Journal: | Pathogens | Abstract: | Several indirect findings suggest that host-related factors influence susceptibility to Coxiella burnetii infection. We decided to explore the influence of genetic factors related to both innate and adaptive immunity in acute Q fever susceptibility. TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) polymorphisms, along with HLA-DRB1 alleles, were analyzed for 38 patients with acute Q fever, 38 matched controls, and 121 blood donors. No significant associations were found for TLR polymorphisms. However, HLA-DRB1*04 was more frequent in patients. HLA-DRB1 variants may play a role in Q fever susceptibility, supporting the need for further investigation into their potential implications for vaccination and risk assessment. | URI: | https://accedacris.ulpgc.es/handle/10553/140112 | ISSN: | 2076-0817 | DOI: | 10.3390/pathogens14040394 | Source: | Pathogens [EISSN 2076-0817], v. 14 (4), (Abril 2025) |
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