Identificador persistente para citar o vincular este elemento: https://accedacris.ulpgc.es/handle/10553/139815
Campo DC Valoridioma
dc.contributor.authorBarac, Franen_US
dc.contributor.authorCastro Alonso, Pedro Luisen_US
dc.contributor.authorHansen, Tom J.en_US
dc.contributor.authorFjelldal, Per G.en_US
dc.contributor.authorKerboeuf, Mikaelen_US
dc.contributor.authorBoysen, Prebenen_US
dc.contributor.authorHordvik, Ivaren_US
dc.contributor.authorBjorgen, Havarden_US
dc.contributor.authorKoppang, Erling O.en_US
dc.date.accessioned2025-06-09T19:33:34Z-
dc.date.available2025-06-09T19:33:34Z-
dc.date.issued2025en_US
dc.identifier.issn0022-1767en_US
dc.identifier.otherWoS-
dc.identifier.urihttps://accedacris.ulpgc.es/handle/10553/139815-
dc.description.abstractFish lack organized mucosa-associated lymphoid tissues as found in birds and mammals. However, a distinct aggregation of lymphoid cells, the interbranchial lymphoid tissue (ILT), was identified in the gills of the Atlantic salmon (Salmo salar) in 2008. Since then, additional structures of similar character have been discovered. The function of the ILT remains elusive, and research has focused primarily on its T cell content. Here, we address the B cell composition of the ILT. Gills of Atlantic salmon from two developmental stages (avg 153 g and avg 1,717 g) were examined from both vaccinated and unvaccinated fish for immunoglobulins IgM, IgT, and IgD, as well as for Activation-Induced Cytidine Deaminase (AID) and Paired Box 5 (Pax5) mRNA by morphological methods. There was an abundance of Ig-transcript+ cells throughout the gill epithelium, with IgD mRNA+ cells being the most numerous. Larger fish had a significantly higher number of IgM mRNA+ cells than the smaller fish, whereas vaccination had no significant impact on any of the isotypes. The immunofluorescence results of Igs paired with Pax5 ISH showed B cells in different stages of maturation within the ILT. Additionally, scattered AID+ cells were present within the pILT. In contrast to what was previously assumed, we show that B cells are abundant in the ILT.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Immunologyen_US
dc.sourceJournal Of Immunology[ISSN 0022-1767], (2025)en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject.otherImmune-Responseen_US
dc.subject.otherRainbow-Trouten_US
dc.subject.otherExpressionen_US
dc.subject.otherThymusen_US
dc.subject.otherPax5en_US
dc.subject.otherIgden_US
dc.subject.otherImmunoglobulinsen_US
dc.subject.otherImmunizationen_US
dc.subject.otherOriginen_US
dc.subject.otherSerumen_US
dc.subject.otherAge Effecten_US
dc.subject.otherIgden_US
dc.subject.otherIgten_US
dc.subject.otherIgmen_US
dc.subject.otherVaccine Effecten_US
dc.titleB-cell distribution and composition in the gills and the interbranchial lymphoid tissue (ILT) of the Atlantic salmon (Salmo salar L.)en_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/jimmun/vkaf081en_US
dc.identifier.isi001495434400001-
dc.identifier.eissn1550-6606-
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.contributor.daisngid19249301-
dc.contributor.daisngid71796600-
dc.contributor.daisngid8802258-
dc.contributor.daisngid21558749-
dc.contributor.daisngid15630447-
dc.contributor.daisngid46357147-
dc.contributor.daisngid29061792-
dc.contributor.daisngid2069590-
dc.contributor.daisngid10370438-
dc.description.numberofpages13en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Barac, F-
dc.contributor.wosstandardWOS:Castro, PL-
dc.contributor.wosstandardWOS:Hansen, TJ-
dc.contributor.wosstandardWOS:Fjelldal, PG-
dc.contributor.wosstandardWOS:Kerboeuf, M-
dc.contributor.wosstandardWOS:Boysen, P-
dc.contributor.wosstandardWOS:Hordvik, I-
dc.contributor.wosstandardWOS:Bjorgen, H-
dc.contributor.wosstandardWOS:Koppang, EO-
dc.date.coverdate2025en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,558
dc.description.jcr3,6
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
dc.description.miaricds11,0
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR Grupo de Investigación en Acuicultura-
crisitem.author.deptIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0002-0395-899X-
crisitem.author.parentorgIU de Investigación en Acuicultura Sostenible y Ec-
crisitem.author.fullNameCastro Alonso, Pedro Luis-
Colección:Artículos
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