Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric Surgery

Abstract

Adipose tissue, in addition to serving as energy storage, can store lipophilic substances, some of which may pose a health risk if massively mobilized during rapid weight loss. This study aimed to biomonitor inorganic elements in obese patients undergoing bariatric surgery and analyze the role of sociodemographic factors. ICP-MS was employed to quantify 55 elements, including elements identified from the ATSDR’s Substance Priority List and rare-earth elements, in serum samples of 58 obese patients before and after bariatric surgery. A total of 39 out of 55 elements were detected, either before or after surgery, in at least one patient. Serum concentrations of gold, copper, mercury, platinum, and selenium significantly decreased after surgery. Serum concentrations of iron and zinc were significantly lower before surgery. Age, sex, diabetes status, arterial hypertension, and family history of obesity were demographic factors associated with the concentration of elements. Correlation analyses showed significant associations between elements and total lipid concentration or body mass index. Our findings indicate a complex interplay between inorganic elements and body fat and provide relevant information regarding the biomonitoring of these chemical elements in a specific and understudied population.