Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/134958
DC FieldValueLanguage
dc.contributor.authorOrekhova, Kseniaen_US
dc.contributor.authorTestori, Camillaen_US
dc.contributor.authorGiorda, Federicaen_US
dc.contributor.authorGrattarola, Carlaen_US
dc.contributor.authorMattioda, Virginiaen_US
dc.contributor.authorDi Guardo ,Giovannien_US
dc.contributor.authorCorona, Cristianoen_US
dc.contributor.authorCastagnaro, Massimoen_US
dc.contributor.authorSierra Pulpillo, Eva Maríaen_US
dc.contributor.authorCasalone, Cristinaen_US
dc.contributor.authorFavole, Alessandraen_US
dc.contributor.authorCentelleghe, Cinziaen_US
dc.contributor.authorMazzariol, Sandroen_US
dc.date.accessioned2024-12-10T14:50:58Z-
dc.date.available2024-12-10T14:50:58Z-
dc.date.issued2024en_US
dc.identifier.issn1932-6203en_US
dc.identifier.otherScopus-
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/134958-
dc.description.abstractCetacean brains are uniquely adapted to diving, but can be affected by diseases and exposure to toxins, triggering neurodegenerative processes that may cause stranding. Some species exhibit a significant post-reproductive lifespan (PRLS), increasing the likelihood of observing cumulative and age-related pathology. Immunohistochemistry against amyloid-β and hyperphosphorylated tau proteins is increasingly implemented to assess Alzheimer’s Disease-like neuropathology in cetaceans, but comparisons between geographically distinct populations, animals of different age groups, sex, and with concomitant pathologies are lacking. We tested 43 cetaceans’ (30 Tursiops truncatus; 13 Stenella coeruleoalba) parietal cortex, our most consistently archived cerebral tissue, in immunohistochemical analyses with amyloid-β oligomer 42 (Aβ-42) and hyperphosphorylated tau (pTau AT180 and AT8) antibodies. Aβ-42 antibody cross-reacted with plaques in three aged bottlenose and two aged striped dolphins, but was more often detected within neurons, glia, and blood vessels of all the dolphins. Histoscore comparisons between dolphins of different ages, sexes, and pathologies revealed significant correlations between older age, viral infections, and plaque presence. Protozoan cysts cross-reacted with Aβ-42 antibody. pTau signal was observed as single foci in neurons and neuropil in two young and two aged bottlenose dolphins. To our knowledge, this study is the first of its kind for the Mediterranean region and will help establish baseline understanding of physiological and pathological expression of proteins associated with human neurodegenerative disease in cetacean brains.en_US
dc.languageengen_US
dc.relation.ispartofPLoS ONEen_US
dc.sourcePLoS ONE[EISSN 1932-6203],v. 19 (11), (Noviembre 2024)en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject.otherAlzheimers-Diseaseen_US
dc.subject.otherAlignmenten_US
dc.subject.otherProteinen_US
dc.subject.otherVirusen_US
dc.subject.otherLobeen_US
dc.titleAmyloid-β and phosphorylated tau screening in bottlenose dolphin (Tursiops truncatus) and striped dolphin (Stenella coeruleoalba) brains from Italy reveals distinct immunohistochemical patterns correlating with age and co-morbidityen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0314085en_US
dc.identifier.scopus85210367938-
dc.identifier.isi001364424600039-
dc.contributor.orcidNO DATA-
dc.contributor.orcid0000-0002-8839-3544-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcid0000-0002-7492-7285-
dc.contributor.orcid0000-0003-4592-1084-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcid0000-0003-4110-4327-
dc.contributor.orcidNO DATA-
dc.contributor.orcid0000-0002-4756-1871-
dc.contributor.authorscopusid57275246000-
dc.contributor.authorscopusid58104064700-
dc.contributor.authorscopusid55972238400-
dc.contributor.authorscopusid6506971779-
dc.contributor.authorscopusid57878256700-
dc.contributor.authorscopusid36860870100-
dc.contributor.authorscopusid6603735852-
dc.contributor.authorscopusid7003313247-
dc.contributor.authorscopusid15742962600-
dc.contributor.authorscopusid16177404700-
dc.contributor.authorscopusid18534491700-
dc.contributor.authorscopusid55573906900-
dc.contributor.authorscopusid24173815500-
dc.identifier.eissn1932-6203-
dc.identifier.issue11-
dc.relation.volume19en_US
dc.investigacionCiencias de la Saluden_US
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.contributor.daisngidNo ID-
dc.description.numberofpages20en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Orekhova, K-
dc.contributor.wosstandardWOS:Testori, C-
dc.contributor.wosstandardWOS:Giorda, F-
dc.contributor.wosstandardWOS:Grattarola, C-
dc.contributor.wosstandardWOS:Mattioda, V-
dc.contributor.wosstandardWOS:Di Guardo, G-
dc.contributor.wosstandardWOS:Corona, C-
dc.contributor.wosstandardWOS:Castagnaro, M-
dc.contributor.wosstandardWOS:Sierra, E-
dc.contributor.wosstandardWOS:Casalone, C-
dc.contributor.wosstandardWOS:Favole, A-
dc.contributor.wosstandardWOS:Centelleghe, C-
dc.contributor.wosstandardWOS:Mazzariol, S-
dc.date.coverdateNoviembre 2024en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr0,839
dc.description.jcr3,7
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
dc.description.miaricds10,7
dc.description.erihplusERIH PLUS
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0003-3749-8845-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameGiorda, Federica-
crisitem.author.fullNameDi Guardo ,Giovanni-
crisitem.author.fullNameSierra Pulpillo, Eva María-
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