Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/134873
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Escolar-Peña, Andrea | en_US |
dc.contributor.author | Delgado-Dolset, María Isabel | en_US |
dc.contributor.author | Pablo-Torres, Carmela | en_US |
dc.contributor.author | Tarin, Carlos | en_US |
dc.contributor.author | Mera-Berriatua, Leticia | en_US |
dc.contributor.author | Cuesta Apausa, María del Pilar | en_US |
dc.contributor.author | González Cuervo, Heleia | en_US |
dc.contributor.author | Sharma, Rinku | en_US |
dc.contributor.author | Kho, Alvin T. | en_US |
dc.contributor.author | Tantisira, Kelan G. | en_US |
dc.contributor.author | McGeachie, Michael J. | en_US |
dc.contributor.author | Rebollido-Rios, Rocio | en_US |
dc.contributor.author | Barber, Domingo | en_US |
dc.contributor.author | Carrillo Díaz, Teresa | en_US |
dc.contributor.author | Izquierdo, Elena | en_US |
dc.contributor.author | Escribese, María M. | en_US |
dc.date.accessioned | 2024-11-29T20:13:53Z | - |
dc.date.available | 2024-11-29T20:13:53Z | - |
dc.date.issued | 2024 | en_US |
dc.identifier.issn | 1661-6596 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/134873 | - |
dc.description.abstract | The mechanisms underlying severe allergic asthma are complex and unknown, meaning it is a challenge to provide the most appropriate treatment. This study aimed to identify novel biomarkers for stratifying allergic asthmatic patients according to severity, and to uncover the biological mechanisms that lead to the development of the severe uncontrolled phenotype. By using miRNA PCR panels, we analyzed the expression of 752 miRNAs in serum samples from control subjects (n = 15) and mild (n = 11) and severe uncontrolled (n = 10) allergic asthmatic patients. We identified 40 differentially expressed miRNAs between severe uncontrolled and mild allergic asthmatic patients. Functional enrichment analysis revealed signatures related to inflammation, angiogenesis, lipid metabolism and mRNA regulation. A random forest classifier trained with DE miRNAs achieved a high accuracy of 97% for severe uncontrolled patient stratification. Validation of the identified biomarkers was performed on a subset of allergic asthmatic patients from the CAMP cohort at Brigham and Women’s Hospital, Harvard Medical School. Four of these miRNAs (hsa-miR-99b-5p, hsa-miR-451a, hsa-miR-326 and hsa-miR-505-3p) were validated, pointing towards their potential as biomarkers for stratifying allergic asthmatic patients by severity and providing insights into severe uncontrolled asthma molecular pathways. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | International Journal of Molecular Sciences | en_US |
dc.source | International Journal of Molecular Sciences [ISSN 1661-6596], v. 25, n. 17, 9425, (Agosto 2024) | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 320508 Enfermedades pulmonares | en_US |
dc.subject | 320701 Alergias | en_US |
dc.subject.other | Allergic asthma | en_US |
dc.subject.other | Biomarkers | en_US |
dc.subject.other | MiRNAs | en_US |
dc.subject.other | Severity | en_US |
dc.title | Specific microRNA Profile Associated with Inflammation and Lipid Metabolism for Stratifying Allergic Asthma Severity | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3390/ijms25179425 | en_US |
dc.identifier.pmid | 39273372 | - |
dc.identifier.scopus | 2-s2.0-85204152026 | - |
dc.contributor.orcid | 0009-0008-8197-6107 | - |
dc.contributor.orcid | 0000-0001-7924-5454 | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | 0000-0003-4385-9467 | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | 0000-0003-3036-2080 | - |
dc.contributor.orcid | 0000-0002-9887-312X | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | 0000-0002-8910-867X | - |
dc.contributor.orcid | 0000-0002-5488-5700 | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | 0000-0001-5057-5150 | - |
dc.identifier.issue | 17 | - |
dc.relation.volume | 25 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.description.numberofpages | 17 | en_US |
dc.utils.revision | Sí | en_US |
dc.date.coverdate | Agosto 2024 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.sjr | 1,179 | |
dc.description.jcr | 5,6 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
dc.description.miaricds | 10,8 | |
item.grantfulltext | open | - |
item.fulltext | Con texto completo | - |
crisitem.author.dept | GIR IUIBS: Patología y Tecnología médica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Médicas y Quirúrgicas | - |
crisitem.author.orcid | 0000-0002-3047-8908 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Carrillo Díaz, Teresa | - |
Appears in Collections: | Artículos |
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