Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/134873
DC FieldValueLanguage
dc.contributor.authorEscolar-Peña, Andreaen_US
dc.contributor.authorDelgado-Dolset, María Isabelen_US
dc.contributor.authorPablo-Torres, Carmelaen_US
dc.contributor.authorTarin, Carlosen_US
dc.contributor.authorMera-Berriatua, Leticiaen_US
dc.contributor.authorCuesta Apausa, María del Pilaren_US
dc.contributor.authorGonzález Cuervo, Heleiaen_US
dc.contributor.authorSharma, Rinkuen_US
dc.contributor.authorKho, Alvin T.en_US
dc.contributor.authorTantisira, Kelan G.en_US
dc.contributor.authorMcGeachie, Michael J.en_US
dc.contributor.authorRebollido-Rios, Rocioen_US
dc.contributor.authorBarber, Domingoen_US
dc.contributor.authorCarrillo Díaz, Teresaen_US
dc.contributor.authorIzquierdo, Elenaen_US
dc.contributor.authorEscribese, María M.en_US
dc.date.accessioned2024-11-29T20:13:53Z-
dc.date.available2024-11-29T20:13:53Z-
dc.date.issued2024en_US
dc.identifier.issn1661-6596en_US
dc.identifier.urihttp://hdl.handle.net/10553/134873-
dc.description.abstractThe mechanisms underlying severe allergic asthma are complex and unknown, meaning it is a challenge to provide the most appropriate treatment. This study aimed to identify novel biomarkers for stratifying allergic asthmatic patients according to severity, and to uncover the biological mechanisms that lead to the development of the severe uncontrolled phenotype. By using miRNA PCR panels, we analyzed the expression of 752 miRNAs in serum samples from control subjects (n = 15) and mild (n = 11) and severe uncontrolled (n = 10) allergic asthmatic patients. We identified 40 differentially expressed miRNAs between severe uncontrolled and mild allergic asthmatic patients. Functional enrichment analysis revealed signatures related to inflammation, angiogenesis, lipid metabolism and mRNA regulation. A random forest classifier trained with DE miRNAs achieved a high accuracy of 97% for severe uncontrolled patient stratification. Validation of the identified biomarkers was performed on a subset of allergic asthmatic patients from the CAMP cohort at Brigham and Women’s Hospital, Harvard Medical School. Four of these miRNAs (hsa-miR-99b-5p, hsa-miR-451a, hsa-miR-326 and hsa-miR-505-3p) were validated, pointing towards their potential as biomarkers for stratifying allergic asthmatic patients by severity and providing insights into severe uncontrolled asthma molecular pathways.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.sourceInternational Journal of Molecular Sciences [ISSN 1661-6596], v. 25, n. 17, 9425, (Agosto 2024)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320508 Enfermedades pulmonaresen_US
dc.subject320701 Alergiasen_US
dc.subject.otherAllergic asthmaen_US
dc.subject.otherBiomarkersen_US
dc.subject.otherMiRNAsen_US
dc.subject.otherSeverityen_US
dc.titleSpecific microRNA Profile Associated with Inflammation and Lipid Metabolism for Stratifying Allergic Asthma Severityen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms25179425en_US
dc.identifier.pmid39273372-
dc.identifier.scopus2-s2.0-85204152026-
dc.contributor.orcid0009-0008-8197-6107-
dc.contributor.orcid0000-0001-7924-5454-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid0000-0003-4385-9467-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid0000-0003-3036-2080-
dc.contributor.orcid0000-0002-9887-312X-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid0000-0002-8910-867X-
dc.contributor.orcid0000-0002-5488-5700-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid0000-0001-5057-5150-
dc.identifier.issue17-
dc.relation.volume25en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages17en_US
dc.utils.revisionen_US
dc.date.coverdateAgosto 2024en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,179
dc.description.jcr5,6
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,8
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Patología y Tecnología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-3047-8908-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCarrillo Díaz, Teresa-
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