Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/130503
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dc.contributor.authorSegura Díaz, Adrianen_US
dc.contributor.authorStuckey, Ruthen_US
dc.contributor.authorFlorido, Yaniraen_US
dc.contributor.authorSobas, Martaen_US
dc.contributor.authorAlvarez-Larran, Albertoen_US
dc.contributor.authorFerrer-Marin, Franciscaen_US
dc.contributor.authorPerez-Encinas, Manuelen_US
dc.contributor.authorCarreno-Tarragona, Gonzaloen_US
dc.contributor.authorFox, Maria L.en_US
dc.contributor.authorTazon Vega, Barbaraen_US
dc.contributor.authorCuevas, Beatrizen_US
dc.contributor.authorLopez Rodriguez, Juan F.en_US
dc.contributor.authorSanchez Farias, Nuriaen_US
dc.contributor.authorGonzalez-Martin, Jesus M.en_US
dc.contributor.authorGómez Casares, María Teresaen_US
dc.contributor.authorBilbao Sieyro, Cristinaen_US
dc.date.accessioned2024-05-17T15:39:56Z-
dc.date.available2024-05-17T15:39:56Z-
dc.date.issued2024en_US
dc.identifier.issn0340-6245en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/130503-
dc.description.abstractBackground Polycythemia vera (PV) patients are classified as high or low thrombotic risk based on age and prior history of thrombosis. Despite adherence to treatment recommendations, vascular events remain frequent, leading us to question whether thrombotic risk stratification could be improved. We previously reported an association between thrombotic events and mutations in DTA genes (DNMT3A, TET2, and ASXL1). The objective of this study was to confirm this observation in a larger series of PV patients. Methods PV patients with a minimum follow-up of 3 years were recruited from 8 European centers. Medical history was searched for thrombotic event recorded at any time and next-generation sequencing carried out with a myeloid panel. Multivariable logistic regression evaluated the impact of variables on thrombotic risk. Kaplan-Meier thrombosis-free survival curves were compared by the log rank test. Associations in the total cohort were confirmed in a case-control study to exclude selection bias. Results Of the 136 patients recruited, 74 (56.1%) had a thrombotic event, with an incidence density of 2.83/100 person-years. In multivariable analysis, DTA mutation was a risk factor for thrombotic event, being predictive for shorter thrombosis-free survival in the whole cohort (p = 0.007), as well as in low-risk patients (p = 0.039) and older patients (p = 0.009), but not for patients with a prediagnostic event. A gender- and age-matched case-control study confirmed the increased risk of thrombotic event for PV patients with a DTA mutation. Conclusion Our results support the use of molecular testing at diagnosis to help predict which PV patients are at higher risk of developing thrombosis.en_US
dc.languageengen_US
dc.relation.ispartofThrombosis and Haemostasisen_US
dc.sourceThrombosis And Haemostasis [ISSN 0340-6245], (2024)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320708 Hematologíaen_US
dc.subject320102 Genética clínicaen_US
dc.subject.otherClonal Hematopoiesisen_US
dc.subject.otherNeoplasmsen_US
dc.subject.otherMyeloproliferative Neoplasmen_US
dc.subject.otherCardiovascular Eventen_US
dc.subject.otherNext-Generation Sequencingen_US
dc.subject.otherPrognosisen_US
dc.subject.otherChipen_US
dc.titleDNMT3A/TET2/ASXL1/ Mutations are an Age-independent Thrombotic Risk Factor in Polycythemia Vera Patients: An Observational Studyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1055/a-2239-9265en_US
dc.identifier.isi001153980800001-
dc.identifier.eissn2567-689X-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid13982043-
dc.contributor.daisngid616098-
dc.contributor.daisngid7626683-
dc.contributor.daisngid47437693-
dc.contributor.daisngid49703745-
dc.contributor.daisngid50710567-
dc.contributor.daisngid29343557-
dc.contributor.daisngid48521238-
dc.contributor.daisngid21375074-
dc.contributor.daisngid54709148-
dc.contributor.daisngid21120337-
dc.contributor.daisngid54706386-
dc.contributor.daisngid7596214-
dc.contributor.daisngid29494273-
dc.contributor.daisngid50564452-
dc.contributor.daisngid54769301-
dc.description.numberofpages7en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Segura-Díaz, A-
dc.contributor.wosstandardWOS:Stuckey, R-
dc.contributor.wosstandardWOS:Florido, Y-
dc.contributor.wosstandardWOS:Sobas, M-
dc.contributor.wosstandardWOS:Alvarez-Larrán, A-
dc.contributor.wosstandardWOS:Ferrer-Marín, F-
dc.contributor.wosstandardWOS:Pérez-Encinas, M-
dc.contributor.wosstandardWOS:Carreño-Tarragona, G-
dc.contributor.wosstandardWOS:Fox, ML-
dc.contributor.wosstandardWOS:Vega, BT-
dc.contributor.wosstandardWOS:Cuevas, B-
dc.contributor.wosstandardWOS:Rodríguez, JFL-
dc.contributor.wosstandardWOS:Farías-Sánchez, N-
dc.contributor.wosstandardWOS:González-Martín, JM-
dc.contributor.wosstandardWOS:Gomez-Casares, MT-
dc.contributor.wosstandardWOS:Bilbao-Sieyro, C-
dc.date.coverdate2024en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,248
dc.description.jcr6,7
dc.description.sjrqQ1
dc.description.jcrqQ1
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0003-0505-5126-
crisitem.author.orcid0000-0002-4796-1445-
crisitem.author.fullNameSegura Díaz, Adrian-
crisitem.author.fullNameGómez Casares, María Teresa-
crisitem.author.fullNameBilbao Sieyro, Cristina-
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