Unlocking the mysteries of colostrogenesis in small ruminants: recent insights and discoveries

Abstract

Colostrogenesis, the process by which mammals produce the initial mammary gland secretion before parturition, is a multifaceted and intricate phenomenon. Variations in colostrum composition have been widely observed, primarily attributed to differences in placental structure. In ruminants, the classical indicator of colostrum quality is IgG concentration, as immunoglobulin transfer from mother to foetus is absent. This manuscript delves into the latest advancements in understanding the physiology of colostrum production, with particular emphasis on the hypothesized role of FcRn. A novel concept explored here is the manipulation of the blood-milk barrier, with accompanying presentation of pertinent findings. Furthermore, factors such as litter size, number of lactations, and nutritional influences are thoroughly examined. The future of colostrogenesis research hinges upon unravelling the mechanisms governing IgG transfer. Understanding this intricate process is essential for advancing our knowledge and optimizing colostrum-related outcomes.