Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/130258
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dc.contributor.authorPumarega, Joséen_US
dc.contributor.authorGasull, Magdaen_US
dc.contributor.authorKoponen, Janien_US
dc.contributor.authorCampi, Lauraen_US
dc.contributor.authorRantakokko, Panuen_US
dc.contributor.authorHenríquez Hernández, Luis Albertoen_US
dc.contributor.authorAguilar, Ruthen_US
dc.contributor.authorDonat-Vargas, Carolinaen_US
dc.contributor.authorZumbado Peña, Manuel Luisen_US
dc.contributor.authorVillar-García, Juditen_US
dc.contributor.authorRius, Cristinaen_US
dc.contributor.authorSantiago-Díaz, Pabloen_US
dc.contributor.authorVidal, Martaen_US
dc.contributor.authorJimenez, Alfonsen_US
dc.contributor.authorIglesias, Maren_US
dc.contributor.authorDobaño, Carlotaen_US
dc.contributor.authorMoncunill, Gemmaen_US
dc.contributor.authorPorta, Miquelen_US
dc.date.accessioned2024-05-09T14:33:38Z-
dc.date.available2024-05-09T14:33:38Z-
dc.date.issued2023en_US
dc.identifier.issn0013-9351en_US
dc.identifier.urihttp://hdl.handle.net/10553/130258-
dc.description.abstractObjective: To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements –measured in individuals’ blood several years before the pandemic– on the development of SARS-CoV-2 infection and COVID-19 disease in the general population. Methods: We conducted a prospective cohort study in 240 individuals from the general population of Barcelona. PFAS, other POPs, and chemical elements were measured in plasma, serum, and whole blood samples, respectively, collected in 2016–2017. PFAS were analyzed by liquid chromatography-triple quadrupole mass spectrometry. SARS-CoV-2 infection was detected by rRT-PCR in nasopharyngeal swabs and/or antibody serology in blood samples collected in 2020–2021. Results: No individual PFAS nor their mixtures were significantly associated with SARS-CoV-2 seropositivity or COVID-19 disease. Previously identified mixtures of POPs and elements (Porta et al., 2023) remained significantly associated with seropositivity and COVID-19 when adjusted for PFAS (all OR > 4 or p < 0.05). Nine chemicals comprised mixtures associated with COVID-19: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, other DDT-related compounds, manganese, tantalum, and aluminium. And nine chemicals comprised the mixtures more consistently associated with SARS-CoV-2 seropositivity: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, gold, and (protectively) selenium, indium, and iron. Conclusions: The PFAS studied were not associated with SARS-CoV-2 seropositivity or COVID-19. The results confirm the associations between personal blood concentrations of some POPs and chemical elements and the risk of COVID-19 and SARS-CoV-2 infection in what remains the only prospective and population-based cohort study on the topic. Mixtures of POPs and chemical elements may contribute to explain the heterogeneity in the risks of SARS-CoV-2 infection and COVID-19 in the general population.en_US
dc.languageengen_US
dc.relation.ispartofEnvironmental research (New York, N.Y. Print)en_US
dc.sourceEnvironmental research [ 0013-9351], v. 237(Pt 2):116965 (Noviembre 2013)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320505 Enfermedades infecciosasen_US
dc.subject.otherCOVID-19en_US
dc.subject.otherImmunotoxicityen_US
dc.subject.otherMixturesen_US
dc.subject.otherPer- and polyfluoroalkyl substances (PFAS)en_US
dc.subject.otherSARS-CoV-2en_US
dc.titlePrepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infectionen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.envres.2023.116965en_US
dc.identifier.pmid37652221-
dc.identifier.scopus2-s2.0-85171458364-
dc.contributor.orcid0000-0001-6950-6702-
dc.contributor.orcid0000-0003-4546-3650-
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dc.contributor.orcid0000-0003-1684-7428-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateNoviembre 2023en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,679
dc.description.jcr8,3
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.orcid0000-0002-1534-7758-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameZumbado Peña, Manuel Luis-
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