Analysis of the Behavior of Ozone Therapy in Chemotherapy-Induced Neuropathy Using Hyperspectral Imaging Technology

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse reaction produced by chemotherapy drugs used to treat cancer. A few of the most common symptoms are pain, discomfort, tingling, numbness, and weakness in the hands, feet, and other parts of the body. The use of ozone therapy (O 3 T) is a novel therapy which aims to reduce these side effects. This study focuses on the visualization of oxygen saturation (StO 2 ) in the extremities in a non-contact fashion employing hyperspectral (HS) imaging (HSI) with the goal of using HSI as a predictive value in the objective assessment of pain after ozone therapy application. A customized acquisition system composed of an HS camera (covering the 470–900 nm spectral range) and a halogen illumination system was developed to capture images of the extremities in a non-contact approach. An experimental clinical procedure was established to measure the evolution of StO 2 in hands and feet using a mathematical model based on information related to two wavelengths (660 and 880 nm). The preliminary results show that, in general, when analyzing the extremities of all unified patients, StO 2 slightly improves but significatively in the peripheral tissues after ozone therapy (O 3 T). HS technology allows the estimation of StO 2 values and allows the quantification of the effect of O 3 T.