Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/128911
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dc.contributor.authorAbraldes, Juan G.en_US
dc.contributor.authorVillanueva, Cándiden_US
dc.contributor.authorBanares, Rafaelen_US
dc.contributor.authorAracil, Carlesen_US
dc.contributor.authorVega Catalina, Maríaen_US
dc.contributor.authorGarcía-Pagán, Juan Carlosen_US
dc.contributor.authorBosch, Jaimeen_US
dc.contributor.authorMonescillo Francia, Alberto Fernando*en_US
dc.date.accessioned2024-02-14T15:38:52Z-
dc.date.available2024-02-14T15:38:52Z-
dc.date.issued2008en_US
dc.identifier.issn0168-8278en_US
dc.identifier.urihttp://hdl.handle.net/10553/128911-
dc.description.abstractBackground/Aims: In acute variceal bleeding (AVB) hepatic venous pressure gradient (HVPG) is associated with prognosis. However, this has not been studied in patients receiving the currently recommended therapy. We evaluate here the performance of early HVPG measurement as a predictor of treatment failure in patients with acute variceal bleeding managed with the current standard treatment and whether clinical variables might be of similar predictive accuracy. Methods: We included 117 patients with AVB in whom HVPG was measured within 48 h of admission. The main endpoint was 5-day failure, a composite of uncontrolled bleeding, early rebleeding or death within 5 days. Results: Eighteen patients (15%) had 5-day failure. Multivariate analysis identified three variables independently associated with 5-day failure: HVPG ≥20, systolic blood pressure at admission <100 mm Hg and non-alcoholic cause of cirrhosis. The discriminative capacity of this model was good (c statistic: 0.79). When only clinical variables were included in the analysis, Child-Pugh class, systolic blood pressure at admission and etiology were the independent predictors. This model had also a good discriminative ability (c statistic: 0.80). Conclusions: HVPG independently predicts short-term prognosis in patients with acute variceal bleeding treated with pharmacologic and endoscopic therapy, but similar predictive accuracy can be achieved using only simple clinical variables that have universal applicability.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Hepatologyen_US
dc.sourceJournal of Hepatology [0168-8278], v. 48(2), p. 229-236 (Febrero 2008)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherPortal hypertensionen_US
dc.subject.otherEndoseopyen_US
dc.subject.otherPrognostic modelsen_US
dc.titleHepatic venous pressure gradient and prognosis in patients with acute variceal bleeding treated with pharmacologic and endoscopic therapyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jhep.2007.10.008en_US
dc.identifier.pmid18093686-
dc.identifier.scopus2-s2.0-38049009057-
dc.identifier.isiWOS:000253324300008-
dc.contributor.orcid#NODATA#-
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dc.description.lastpage236en_US
dc.identifier.issue2-
dc.description.firstpage229en_US
dc.relation.volume48en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.notas* Miembro del Spanish Cooperative Group for Portal Hypertension and Variceal Bleedingen_US
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.date.coverdateFebrero 2008en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr7,056
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-9490-4427-
crisitem.author.fullNameMonescillo Francia, Alberto Fernando-
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