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http://hdl.handle.net/10553/127745
Title: | Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment | Authors: | Jabłońska-Trypuć, Agata Wydro, Urszula Wołejko, Elżbieta Makuła, Marcin Krętowski, Rafał Naumowicz, Monika Sokołowska, Gabriela Serra Majem, Luis Cechowska-Pasko, Marzanna Łozowicka, Bożena Kaczyński, Piotr Wiater, Józefa |
UNESCO Clasification: | 32 Ciencias médicas 3205 Medicina interna 2403 Bioquímica 310105 Fungicidas 2407 Biología celular |
Keywords: | Boscalid Breast Cancer Cyprodinil Edc Compounds Iprodione |
Issue Date: | 2023 | Journal: | Molecules | Abstract: | An increasing level of pesticide exposition is being observed as a result of the consumption of large amounts of fruits, vegetables and grain products, which are key components of the vegetarian diet. Fungicides have been classified as endocrine-disrupting compounds, but their mechanisms of action have not yet been clarified. The effect of boscalid (B), cyprodinil (C) and iprodione (I) combined with Tamoxifen (T) and 17β-estradiol (E2) on cell viability, cell proliferation, reporter gene expression, ROS content, the cell membrane’s function, cell morphology and antioxidant enzymes gene expression in MCF-7 and T47D-KBluc cell lines were investigated. The cell lines were chosen due to their response to 17β -estradiol. The selected fungicides are commonly used in Poland to protect crops against fungi. Our results revealed that the studied fungicides caused significant increases in cell viability and proliferation, and estrogenic activity was present in all studied compounds depending on their concentrations. Oxidative stress activated uncontrolled cancer cell proliferation by inducing ROS production and by inhibiting antioxidant defense. Our findings verify that the studied fungicides could possibly exhibit endocrine-disrupting properties and exposure should be avoided. | URI: | http://hdl.handle.net/10553/127745 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules28217437 | Source: | Molecules[EISSN 1420-3049],v. 28 (21), (Noviembre 2023) |
Appears in Collections: | Artículos |
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