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http://hdl.handle.net/10553/127324
Título: | Serum and urine metabolomic profiling of newly diagnosed treatment-naive inflammatory bowel disease patients | Autores/as: | Aldars García, L. Gil Redondo, R. Embade, N. Bode Riestra, Antonio Rivero, M. Gutiérrez, A. Rodríguez Lago, I. Fernández-Salazar, L. Ceballos, D. Benitez, JM Aguas, M. Baston Rey, I. Bermejo, F. Casanova, MJ Lorente, R. Ber, Y. Ginard, D. Esteve, M. de Francisco, R. Sánchez García, María José Francés, R Pescador, AR Velayos, B. del Río, EG Pedrosa, SM Sabater, AM Acosta, MBD Algaba, A. Gil, CV Rivas, O. Royo, V. Aceituno, M. Garre, A. Baldán Martín, M. Ramírez, C. Sanz García, A. Lozano, JJ Sidorova, J Millet, O. Bernardo, D. Gisbert, JP Chaparro, M. |
Clasificación UNESCO: | 32 Ciencias médicas 320505 Enfermedades infecciosas |
Palabras clave: | Inflammatory bowel disease Crohn's disease Ulcerative colitis Metabolomics |
Fecha de publicación: | 2024 | Publicación seriada: | Inflammatory Bowel Diseases | Resumen: | Inflammatory bowel disease (IBD) is a prevalent chronic noncurable disease associated with profound metabolic changes. The discovery of novel molecular indicators for unraveling IBD etiopathogenesis and the diagnosis and prognosis of IBD is therefore pivotal. We sought to determine the distinctive metabolic signatures from the different IBD subgroups before treatment initiation. Methods Serum and urine samples from newly diagnosed treatment-naïve IBD patients and age and sex-matched healthy control (HC) individuals were investigated using proton nuclear magnetic resonance spectroscopy. Metabolic differences were identified based on univariate and multivariate statistical analyses. Results A total of 137 Crohn’s disease patients, 202 ulcerative colitis patients, and 338 HC individuals were included. In the IBD cohort, several distinguishable metabolites were detected within each subgroup comparison. Most of the differences revealed alterations in energy and amino acid metabolism in IBD patients, with an increased demand of the body for energy mainly through the ketone bodies. As compared with HC individuals, differences in metabolites were more marked and numerous in Crohn’s disease than in ulcerative colitis patients, and in serum than in urine. In addition, clustering analysis revealed 3 distinct patient profiles with notable differences among them based on the analysis of their clinical, anthropometric, and metabolomic variables. However, relevant phenotypical differences were not found among these 3 clusters. Conclusions This study highlights the molecular alterations present within the different subgroups of newly diagnosed treatment-naïve IBD patients. The metabolomic profile of these patients may provide further understanding of pathogenic mechanisms of IBD subgroups. Serum metabotype seemed to be especially sensitive to the onset of IBD. | URI: | http://hdl.handle.net/10553/127324 | ISSN: | 1078-0998 | DOI: | 10.1093/ibd/izad154 | Fuente: | Inflammatory Bowel Diseases, [ISSN 1078-0998], v. 30(2), p. 167-182 (Febrero 2024). |
Colección: | Artículos |
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