Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/127187
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dc.contributor.authorSantana Viera, Sergioen_US
dc.contributor.authorAlameda Cuesta, Águedaen_US
dc.contributor.authorMontesdeoca Esponda, Sarahen_US
dc.contributor.authorSosa Ferrera, María Zoraidaen_US
dc.contributor.authorSantana-Rodriguez, José Juanen_US
dc.date.accessioned2023-10-09T12:03:37Z-
dc.date.available2023-10-09T12:03:37Z-
dc.date.issued2023en_US
dc.identifier.issn0026-265Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/127187-
dc.description.abstractPresence of antidepressants in aquatic environments could cause adverse effects even at low concentrations. Most published works have detected them in wastewater, and only a few have paid attention to the aquatic organisms that receive these polluted waters. This work presents the development, optimisation and application of an analytical method for the extraction and determination of four widely used antidepressants (venlafaxine, citalopram, sertraline, fluoxetine) and two metabolites (o-desmethylvenlafaxine, norsetraline) from fish tissue by microwave-assisted extraction and ultra high-performance liquid chromatography coupled to tandem mass spectrometry. To demonstrate the applicability of the method, it was validated in different marine organism species (fish, echinoderm, mollusc and algae). Under optimal conditions, recovery ranged between 70 and 120 % and deviation was lower than 20 % in most cases, depending on the species and the tested concentration. As no strong matrix effect was found, applying a clean-up step was unnecessary, although quantification was performed in real samples by matrix-matched calibration. Method quantification limits ranged between 2.32 and 196 ng g−1. Overall, this methodology proved to be a versatile method applicable to different species with good results. The developed analytical method was successfully applied to the extraction and determination of the target compounds from fish taken from offshore aquaculture cages in seawater (Canary Islands). Three main antidepressants were detected, but only two could be quantified: citalopram: 5.83 ng g−1 and sertraline: 6.58 ng g−1.en_US
dc.languageengen_US
dc.relation.ispartofMicrochemical Journalen_US
dc.sourceMicrochemical Journal [ISSN 0026-265X], v. 195, 109471, diciembre 2023en_US
dc.subject320901 Análisis de medicamentosen_US
dc.subject250811 Calidad de las aguasen_US
dc.subject.otherAntidepressant compoundsen_US
dc.subject.otherFish tissueen_US
dc.subject.otherMollusc tissueen_US
dc.subject.otherSolid samplesen_US
dc.subject.otherMicrowave-assisted extractionen_US
dc.subject.otherLiquid chromatographyen_US
dc.subject.otherMass spectrometryen_US
dc.titleRapid microwave-assisted extraction method for the analysis of common antidepressants and metabolites in marine organismsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.microc.2023.109471en_US
dc.relation.volume195en_US
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.date.coverdateDiciembre 2023en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-BASen_US
dc.description.sjr0,742-
dc.description.jcr4,8-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
dc.description.miaricds11,0-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.orcid0000-0002-2412-0037-
crisitem.author.orcid0000-0001-9872-5293-
crisitem.author.orcid0000-0003-3003-3607-
crisitem.author.orcid0000-0002-5635-7215-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.fullNameSantana Viera, Sergio-
crisitem.author.fullNameMontesdeoca Esponda, Sarah-
crisitem.author.fullNameSosa Ferrera, María Zoraida-
crisitem.author.fullNameSantana Rodríguez, José Juan-
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