Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/123781
Campo DC | Valor | idioma |
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dc.contributor.author | Fernández Rodríguez, Antonio Jesús | - |
dc.contributor.author | Câmara, Nakita | - |
dc.contributor.author | Sierra Pulpillo, Eva María | - |
dc.contributor.author | Arbelo Hernández, Manuel Antonio | - |
dc.contributor.author | Bernaldo De Quirós Miranda, Yara | - |
dc.contributor.author | Jepson, Paul D. | - |
dc.contributor.author | Deaville, Rob | - |
dc.contributor.author | Diaz Delgado,Josue | - |
dc.contributor.author | Suarez Santana, Cristian Manuel | - |
dc.contributor.author | Castro Alonso, Ayoze | - |
dc.contributor.author | Hernández Vega, Julia Natividad | - |
dc.contributor.author | Alves Godinho,Ana | - |
dc.date.accessioned | 2023-06-29T09:18:24Z | - |
dc.date.available | 2023-06-29T09:18:24Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 2076-2615 | - |
dc.identifier.other | Scopus | - |
dc.identifier.uri | http://hdl.handle.net/10553/123781 | - |
dc.description.abstract | The nature, etiopathogenesis, and clinicopathologic relevance of the prevalent intracytoplasmic eosinophilic globules (IEGs) within hepatocytes of cetaceans are unknown. This study aims to evaluate the presence and characterize the IEGs in the hepatocytes of cetaceans using histochemical and immunohistochemical electron microscopy, Western blot, lectin histochemistry, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry techniques. A total of 95/115 (83%) animals (16 species) exhibited histologically evident intracytoplasmic round to oval, single to multiple, hyaline eosinophilic globules within the hepatocytes. These globules were largely PAS-positive, diastase resistant, and were immunopositive for fibrinogen (FB, 97%), albumin (Alb, 85%), and α1-antitrypsine (A1AT, 53%). The IEG positivity for FB and A1AT were correlated with live-stranding, hepatic congestion and a good nutritional status. The cetaceans lacking IEGs were consistently dead stranded and had poor body conditions. The IEGs in 36 bycaught cetaceans were, all except one, FB-positive and A1AT-negative. The IEGs exhibited morphologic and compositional variations at the ultrastructural level, suggesting various stages of development and/or etiopathogenesis(es). The glycocalyx analysis suggested an FB- and A1AT-glycosylation pattern variability between cetaceans and other animals. The proteomic analyses confirmed an association between the IEGs and acute phase proteins, suggesting a relationship between acute stress (i.e., bycatch), disease, and cellular protective mechanisms, allowing pathologists to correlate this morphological change using the acute hepatocytic cell response under certain stress conditions. | - |
dc.language | eng | - |
dc.relation | Patología Embólica (Gaseosa/Grasa) en Cetáceos | - |
dc.relation.ispartof | Animals | - |
dc.source | Animals [EISSN 2076-2615],v. 13 (13), 2130, (Junio 2023) | - |
dc.subject | 310907 Patología | - |
dc.subject | 240110 Histología animal | - |
dc.subject | 240119 Zoología marina | - |
dc.subject.other | Albumin | - |
dc.subject.other | α1-antitrypsine | - |
dc.subject.other | Bycatch | - |
dc.subject.other | Cetacean | - |
dc.subject.other | Fibrinogen | - |
dc.subject.other | Intracytoplasmic hyaline globules | - |
dc.subject.other | Livestranding | - |
dc.subject.other | Liver | - |
dc.subject.other | Marine mammal pathology | - |
dc.title | Cetacean Intracytoplasmic Eosinophilic Globules: A Cytomorphological, Histological, Histochemical, Immunohistochemical, and Proteomic Characterization | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ani13132130 | - |
dc.identifier.scopus | 85164671099 | - |
dc.contributor.orcid | 0000-0001-5281-0521 | - |
dc.contributor.orcid | 0000-0001-8307-3915 | - |
dc.contributor.orcid | 0000-0003-3749-8845 | - |
dc.contributor.orcid | 0000-0002-1623-5010 | - |
dc.contributor.orcid | 0000-0002-2611-0406 | - |
dc.contributor.orcid | 0000-0002-7245-375X | - |
dc.contributor.orcid | NO DATA | - |
dc.contributor.orcid | 0000-0003-1216-5446 | - |
dc.contributor.orcid | 0000-0002-0409-6156 | - |
dc.contributor.orcid | 0000-0002-2243-5449 | - |
dc.contributor.orcid | 0000-0002-3843-2509 | - |
dc.contributor.orcid | 0000-0001-5549-8684 | - |
dc.contributor.authorscopusid | 56673009900 | - |
dc.contributor.authorscopusid | 57191486481 | - |
dc.contributor.authorscopusid | 15742962600 | - |
dc.contributor.authorscopusid | 6603561403 | - |
dc.contributor.authorscopusid | 40461313300 | - |
dc.contributor.authorscopusid | 7006738308 | - |
dc.contributor.authorscopusid | 6603658704 | - |
dc.contributor.authorscopusid | 54787562800 | - |
dc.contributor.authorscopusid | 56719731800 | - |
dc.contributor.authorscopusid | 58486735100 | - |
dc.contributor.authorscopusid | 57188977277 | - |
dc.contributor.authorscopusid | 57212213423 | - |
dc.identifier.eissn | 2076-2615 | - |
dc.identifier.issue | 13 | - |
dc.relation.volume | 13 | - |
dc.investigacion | Ciencias de la Salud | - |
dc.type2 | Artículo | - |
dc.utils.revision | Sí | - |
dc.date.coverdate | Julio 2023 | - |
dc.identifier.ulpgc | Sí | - |
dc.contributor.buulpgc | BU-VET | - |
dc.description.sjr | 0,698 | - |
dc.description.jcr | 3,0 | - |
dc.description.sjrq | Q1 | - |
dc.description.jcrq | Q1 | - |
dc.description.scie | SCIE | - |
dc.description.miaricds | 10,5 | - |
item.grantfulltext | open | - |
item.fulltext | Con texto completo | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina) | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina) | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina) | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina) | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina) | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina) | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina) | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.orcid | 0000-0001-5281-0521 | - |
crisitem.author.orcid | 0000-0001-8307-3915 | - |
crisitem.author.orcid | 0000-0003-3749-8845 | - |
crisitem.author.orcid | 0000-0002-1623-5010 | - |
crisitem.author.orcid | 0000-0002-2611-0406 | - |
crisitem.author.orcid | 0000-0003-1216-5446 | - |
crisitem.author.orcid | 0000-0002-0409-6156 | - |
crisitem.author.orcid | 0000-0002-2243-5449 | - |
crisitem.author.orcid | 0000-0002-3843-2509 | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.fullName | Fernández Rodríguez, Antonio Jesús | - |
crisitem.author.fullName | Camara, Nakita | - |
crisitem.author.fullName | Sierra Pulpillo, Eva María | - |
crisitem.author.fullName | Arbelo Hernández, Manuel Antonio | - |
crisitem.author.fullName | Bernaldo De Quirós Miranda, Yara | - |
crisitem.author.fullName | Diaz Delgado,Josue | - |
crisitem.author.fullName | Suarez Santana, Cristian Manuel | - |
crisitem.author.fullName | Castro Alonso, Ayoze | - |
crisitem.author.fullName | Hernández Vega, Julia Natividad | - |
crisitem.author.fullName | Alves Godinho,Ana | - |
crisitem.project.principalinvestigator | Fernández Rodríguez, Antonio Jesús | - |
Colección: | Artículos |
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