Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/123781
Campo DC Valoridioma
dc.contributor.authorFernández Rodríguez, Antonio Jesús-
dc.contributor.authorCâmara, Nakita-
dc.contributor.authorSierra Pulpillo, Eva María-
dc.contributor.authorArbelo Hernández, Manuel Antonio-
dc.contributor.authorBernaldo De Quirós Miranda, Yara-
dc.contributor.authorJepson, Paul D.-
dc.contributor.authorDeaville, Rob-
dc.contributor.authorDiaz Delgado,Josue-
dc.contributor.authorSuarez Santana, Cristian Manuel-
dc.contributor.authorCastro Alonso, Ayoze-
dc.contributor.authorHernández Vega, Julia Natividad-
dc.contributor.authorAlves Godinho,Ana-
dc.date.accessioned2023-06-29T09:18:24Z-
dc.date.available2023-06-29T09:18:24Z-
dc.date.issued2023-
dc.identifier.issn2076-2615-
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/123781-
dc.description.abstractThe nature, etiopathogenesis, and clinicopathologic relevance of the prevalent intracytoplasmic eosinophilic globules (IEGs) within hepatocytes of cetaceans are unknown. This study aims to evaluate the presence and characterize the IEGs in the hepatocytes of cetaceans using histochemical and immunohistochemical electron microscopy, Western blot, lectin histochemistry, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry techniques. A total of 95/115 (83%) animals (16 species) exhibited histologically evident intracytoplasmic round to oval, single to multiple, hyaline eosinophilic globules within the hepatocytes. These globules were largely PAS-positive, diastase resistant, and were immunopositive for fibrinogen (FB, 97%), albumin (Alb, 85%), and α1-antitrypsine (A1AT, 53%). The IEG positivity for FB and A1AT were correlated with live-stranding, hepatic congestion and a good nutritional status. The cetaceans lacking IEGs were consistently dead stranded and had poor body conditions. The IEGs in 36 bycaught cetaceans were, all except one, FB-positive and A1AT-negative. The IEGs exhibited morphologic and compositional variations at the ultrastructural level, suggesting various stages of development and/or etiopathogenesis(es). The glycocalyx analysis suggested an FB- and A1AT-glycosylation pattern variability between cetaceans and other animals. The proteomic analyses confirmed an association between the IEGs and acute phase proteins, suggesting a relationship between acute stress (i.e., bycatch), disease, and cellular protective mechanisms, allowing pathologists to correlate this morphological change using the acute hepatocytic cell response under certain stress conditions.-
dc.languageeng-
dc.relationPatología Embólica (Gaseosa/Grasa) en Cetáceos-
dc.relation.ispartofAnimals-
dc.sourceAnimals [EISSN 2076-2615],v. 13 (13), 2130, (Junio 2023)-
dc.subject310907 Patología-
dc.subject240110 Histología animal-
dc.subject240119 Zoología marina-
dc.subject.otherAlbumin-
dc.subject.otherα1-antitrypsine-
dc.subject.otherBycatch-
dc.subject.otherCetacean-
dc.subject.otherFibrinogen-
dc.subject.otherIntracytoplasmic hyaline globules-
dc.subject.otherLivestranding-
dc.subject.otherLiver-
dc.subject.otherMarine mammal pathology-
dc.titleCetacean Intracytoplasmic Eosinophilic Globules: A Cytomorphological, Histological, Histochemical, Immunohistochemical, and Proteomic Characterization-
dc.typeinfo:eu-repo/semantics/article-
dc.typeArticle-
dc.identifier.doi10.3390/ani13132130-
dc.identifier.scopus85164671099-
dc.contributor.orcid0000-0001-5281-0521-
dc.contributor.orcid0000-0001-8307-3915-
dc.contributor.orcid0000-0003-3749-8845-
dc.contributor.orcid0000-0002-1623-5010-
dc.contributor.orcid0000-0002-2611-0406-
dc.contributor.orcid0000-0002-7245-375X-
dc.contributor.orcidNO DATA-
dc.contributor.orcid0000-0003-1216-5446-
dc.contributor.orcid0000-0002-0409-6156-
dc.contributor.orcid0000-0002-2243-5449-
dc.contributor.orcid0000-0002-3843-2509-
dc.contributor.orcid0000-0001-5549-8684-
dc.contributor.authorscopusid56673009900-
dc.contributor.authorscopusid57191486481-
dc.contributor.authorscopusid15742962600-
dc.contributor.authorscopusid6603561403-
dc.contributor.authorscopusid40461313300-
dc.contributor.authorscopusid7006738308-
dc.contributor.authorscopusid6603658704-
dc.contributor.authorscopusid54787562800-
dc.contributor.authorscopusid56719731800-
dc.contributor.authorscopusid58486735100-
dc.contributor.authorscopusid57188977277-
dc.contributor.authorscopusid57212213423-
dc.identifier.eissn2076-2615-
dc.identifier.issue13-
dc.relation.volume13-
dc.investigacionCiencias de la Salud-
dc.type2Artículo-
dc.utils.revision-
dc.date.coverdateJulio 2023-
dc.identifier.ulpgc-
dc.contributor.buulpgcBU-VET-
dc.description.sjr0,698-
dc.description.jcr3,0-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
dc.description.miaricds10,5-
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.orcid0000-0001-5281-0521-
crisitem.author.orcid0000-0001-8307-3915-
crisitem.author.orcid0000-0003-3749-8845-
crisitem.author.orcid0000-0002-1623-5010-
crisitem.author.orcid0000-0002-2611-0406-
crisitem.author.orcid0000-0003-1216-5446-
crisitem.author.orcid0000-0002-0409-6156-
crisitem.author.orcid0000-0002-2243-5449-
crisitem.author.orcid0000-0002-3843-2509-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameFernández Rodríguez, Antonio Jesús-
crisitem.author.fullNameCamara, Nakita-
crisitem.author.fullNameSierra Pulpillo, Eva María-
crisitem.author.fullNameArbelo Hernández, Manuel Antonio-
crisitem.author.fullNameBernaldo De Quirós Miranda, Yara-
crisitem.author.fullNameDiaz Delgado,Josue-
crisitem.author.fullNameSuarez Santana, Cristian Manuel-
crisitem.author.fullNameCastro Alonso, Ayoze-
crisitem.author.fullNameHernández Vega, Julia Natividad-
crisitem.author.fullNameAlves Godinho,Ana-
crisitem.project.principalinvestigatorFernández Rodríguez, Antonio Jesús-
Colección:Artículos
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