Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/123587
Title: An overview of polymeric composite scaffolds with piezoelectric properties for improved bone regeneration
Authors: Donate González, Ricardo 
Paz Hernández, Rubén 
Moriche, Rocío
Sayagués, María Jesús
Alemán-Domínguez, Maria Elena 
Monzón Verona, Mario Domingo 
UNESCO Clasification: 3314 Tecnología médica
Keywords: Biomaterials
Bone Tissue Engineering
Piezoelectricity
Additive Manufacturing
Perovskite structure
Issue Date: 2023
Project: Nuevos Scaffolds Piezoeléctricos de Compuestos Nanoestructurados Para la Regeneración Ósea Mediante Fabricación Aditiva 
Journal: Materials and Design 
Abstract: Despite the dramatic change that Tissue Engineering or stem cell therapies have brought to current therapeutic strategies, there is a lack of functionalities in the available biomaterials for manufacturing scaffolds to treat several highly prevalent osseous diseases (osteochondral defects, osteoporosis, etc.). One promising approach to fill this gap involves the development of innovative piezoelectric scaffolds for improved bone regeneration. Scaffolds with the appropriate piezoelectricity can positively influence the proliferation and differentiation of mesenchymal stem cells to regenerate bone tissue, since surface electrical charges play a key role in the mechanotransduction process. In this work, polymeric-based composite scaffolds with piezoelectric properties intended for bone tissue engineering are reviewed. Special attention is paid to biocompatible, piezoelectric polymers that show suitable properties to be processed by additive manufacturing techniques. Previous works on composite scaffolds based of these polymeric matrices and containing piezoceramic additives are summarized. The use of piezoelectric nanostructured composite formulations containing lead-free ceramic oxide nanoparticles with perovskite structure is highlighted. Also, different commonly applied mechanical stimuli to activate the piezoelectric effect of the developed materials are presented. Finally, other applications of such scaffolds are mentioned, including their capabilities for real-time monitoring.
URI: http://hdl.handle.net/10553/123587
ISSN: 0264-1275
DOI: 10.1016/j.matdes.2023.112085
Source: Materials and Design [ISSN 0264-1275], v. 231, 112085, (Julio 2023)
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