Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/122002
Title: Bio-guided isolation of antiproliferative microalgae cultures
Authors: Ramírez Guerra, Alba
Rodríguez Pérez, Elsa María 
Díaz Marrero, Ana R.
Portillo Hanhefeld, Agustín
UNESCO Clasification: 241707 Algología (ficología)
339001 Biotecnología de microalgas
Keywords: Marine natural products
Triglycerides
Sterols
Polyphenols
Antiproliferative activity, et al
Issue Date: 2023
Publisher: Servicio de Publicaciones y Difusión Científica de la Universidad de Las Palmas de Gran Canaria (ULPGC) 
Conference: VIII International Symposium on Marine Sciences (ISMS 2022) 
Abstract: The search for new therapeutic agents for the treatment of diseases such as cancer is a topic of special interest as alternative to fight the increasing resistance to antiproliferative drugs (De Vera et al., 2018). That is why attention is focused on the study of the marine ecosystem as a potential source of new compounds. The exceptional diversity of chemical components of microalgae and their high unused biomass may represent a main step in the development of anticancer drugs (El-Hacka et al., 2019). The present study shows the bio-guided isolation of two extracts of the species Chrysoreinhardia giraudii cultured in two different nutrient medium (F/2 and seawater diluted centrate-SDC) (Arashiro et al., 2020) in 80-400 L photobioreactors under outdoor natural conditions. Both extracts showed antiproliferative activity when tested against 6 cancer cell lines. Different chromatographic techniques allowed to separate the active compounds and their molecular structures analyzed by application of spectroscopic and spectrometric methods. The results show that most of the active compounds isolated from the F/2 extract fit a characteristic pattern of triglycerides and fatty acids, and also an active sterol was isolated. Additionally, the SDC extract yielded a halogenated polyphenolic nature compound. This work demonstrate the importance of culture medium as a key factor in the production of secondary metabolites, and constitutes the first chemical study of the species C. giraudii.
URI: http://hdl.handle.net/10553/122002
ISBN: 978-84-9042-477-3
Source: Abstracts Volume VIII International Symposium on Marine Sciences, July 2022 / coordinación, María Esther Torres Padrón, p. 234-235
Appears in Collections:Póster de congreso
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