Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/119392
Campo DC Valoridioma
dc.contributor.authorMartín Rodríguez, Alberto Jonatanen_US
dc.contributor.authorTicona, JCen_US
dc.contributor.authorJimenez, IAen_US
dc.contributor.authorFlores, Nen_US
dc.contributor.authorFernandez, JJen_US
dc.contributor.authorBazzocchi, ILen_US
dc.date.accessioned2022-11-25T15:14:34Z-
dc.date.available2022-11-25T15:14:34Z-
dc.date.issued2015en_US
dc.identifier.isbn00319422-
dc.identifier.issn0031-9422en_US
dc.identifier.urihttp://hdl.handle.net/10553/119392-
dc.description.abstractQuorum sensing (QS), or bacterial cell-to-cell communication, is a key process for bacterial colonization of substrata through biofilm formation, infections, and production of virulence factors. In an ongoing investigation of bioactive secondary metabolites from Piper species, four new flavonoids (1-4), along with five known ones (5-9) were isolated from the leaves of Piper delineatum. Their stereostructures were established by spectroscopic and spectrometric methods, including 1D and 2D NMR experiments, and comparison with data reported in the literature. The compounds were screened for their ability to interfere with QS signaling in the bacterial model Vibrio harveyi. Four compounds from this series (2, 3, 6, and 7) exhibited remarkable activity in the micromolar range, being compounds 3 and 7 particularly attractive since they did not affect bacterial growth. The results suggest that these flavonoids disrupt QS-mediated bioluminescence by interaction with elements downstream LuxO in the QS circuit of V. harveyi, and also, they exhibited a strong dose-dependent inhibition of biofilm formation. The present findings shed light on the QS inhibition mechanisms of flavonoids, underlining their potential applications.en_US
dc.languageengen_US
dc.relation.ispartofPhytochemistryen_US
dc.sourcePhytochemistry [0031-9422], v. 117, pp. 98-106 (Septiembre 2015)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320103 Microbiología clínicaen_US
dc.subject2306 Química orgánicaen_US
dc.subject.otherBiofilmen_US
dc.subject.otherFlavonoidsen_US
dc.subject.otherFlavonoidsen_US
dc.subject.otherPiper delineatumen_US
dc.subject.otherQuorum sensingen_US
dc.subject.otherVibrio harveyien_US
dc.titleFlavonoids from Piper delineatum modulate quorum-sensing-regulated phenotypes in Vibrio harveyien_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.phytochem.2015.06.006en_US
dc.identifier.pmid26070141-
dc.identifier.scopus2-s2.0-84930942185-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.description.lastpage106en_US
dc.description.firstpage98en_US
dc.relation.volume117en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.external49585791-
dc.description.numberofpages9en_US
dc.utils.revisionen_US
dc.date.coverdateSeptiembre 2015en_US
dc.identifier.ulpgcNoen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr0,897
dc.description.jcr2,779
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR Investigación Básica y Aplicada en Ciencias de la Salud-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-2422-129X-
crisitem.author.parentorgDepartamento de Ciencias Clínicas-
crisitem.author.fullNameMartín Rodríguez, Alberto Jonatan-
Colección:Artículos
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