Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/118776
DC FieldValueLanguage
dc.contributor.authorSacchini, Simonaen_US
dc.contributor.authorFernández Rodríguez, Antonio Jesúsen_US
dc.contributor.authorMompeó Corredera, Blanca Rosaen_US
dc.contributor.authorMedina Ramírez, Raquel Irinaen_US
dc.contributor.authorArbelo Hernández, Manuel Antonioen_US
dc.contributor.authorHolgersen, Unnen_US
dc.contributor.authorQuesada Canales, Ildefonso Óscaren_US
dc.contributor.authorCastro Alonso, Ayozeen_US
dc.contributor.authorAndrada Borzollino, Marisa Anaen_US
dc.date.accessioned2022-10-05T10:09:05Z-
dc.date.available2022-10-05T10:09:05Z-
dc.date.issued2022en_US
dc.identifier.issn2306-7381en_US
dc.identifier.urihttp://hdl.handle.net/10553/118776-
dc.description.abstractNeuromelanin (NM) is a dark polymer pigment that is located mostly in the human substantia nigra, and in the locus ceruleus, referred to as “the blue spot”. NM increases linearly with age, and has been described mainly in the human brain; however, it also occurs in the neurons of monkeys, horses, giraffes, cattle, sheep, goats, dogs, rats, and even in frogs. While in most of these mammals NM shows the histochemical and ultrastructural features typical of lipofuscins, human NM is confined within cytoplasmic organelles that are surrounded by a double membrane, suggesting an autophagic origin. In a study on the morphology of the locus ceruleus of the family Delphinidae, the presence of a variable quantity of NM in the interior of locus ceruleus neurons was observed for the first time; meanwhile, nothing is known about its ultrastructure and composition. Transmission electron microscopy demonstrated in two toothed whales—an Atlantic spotted dolphin (Stenella frontalis; family Delphinidae) and a Blainville’s beaked whale (Mesoplodon densirostris; family Ziphiidae)—the presence of melanin granules associated with lipid droplets and membranes that were very similar to that of human NM. The relationship between NM and neuronal vulnerability must be studied in depth, and cetaceans may offer a new natural-spontaneous comparative model for the study of NM and its implication in neurodegenerative diseases.en_US
dc.languageengen_US
dc.relationPatologia Embolica (Gaseosa/Grasa) en Cetaceos (Pegcet-3)en_US
dc.relation.ispartofVeterinary Sciencesen_US
dc.sourceVeterinary Sciences [2306-7381], v.9en_US
dc.subject310901 Anatomíaen_US
dc.titleToothed Whales Have Black Neurons in the Blue Spoten_US
dc.typeArticleen_US
dc.identifier.doi10.3390/vetsci9100525en_US
dc.identifier.issue10-
dc.relation.volume9en_US
dc.investigacionCiencias de la Saluden_US
dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.date.coverdateSeptiembre, 2022en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr0,52
dc.description.jcr2,304
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.miaricds10,3
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.project.principalinvestigatorFernández Rodríguez, Antonio Jesús-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0001-6493-1275-
crisitem.author.orcid0000-0001-5281-0521-
crisitem.author.orcid0000-0003-4953-7653-
crisitem.author.orcid0000-0002-1623-5010-
crisitem.author.orcid0000-0002-2243-5449-
crisitem.author.orcid0000-0002-2411-9714-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameSacchini, Simona-
crisitem.author.fullNameFernández Rodríguez, Antonio Jesús-
crisitem.author.fullNameMompeó Corredera, Blanca Rosa-
crisitem.author.fullNameMedina Ramírez, Raquel Irina-
crisitem.author.fullNameArbelo Hernández, Manuel Antonio-
crisitem.author.fullNameQuesada Canales, Ildefonso Óscar-
crisitem.author.fullNameCastro Alonso, Ayoze-
crisitem.author.fullNameAndrada Borzollino, Marisa Ana-
Appears in Collections:Artículos
Adobe PDF (6,78 MB)
Show simple item record

Page view(s)

27
checked on Dec 17, 2022

Download(s)

8
checked on Dec 17, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.