Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/118309
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dc.contributor.authorRuiz-Santana, Sergioen_US
dc.contributor.authorMora-Quintero, María Luisaen_US
dc.contributor.authorSaavedra, Pedroen_US
dc.contributor.authorMontiel-González, Raquelen_US
dc.contributor.authorSánchez-Ramírez, Catalinaen_US
dc.contributor.authorPérez-Acosta, Guillermoen_US
dc.contributor.authorMartín-Velasco, Maren_US
dc.contributor.authorRodríguez-Mata, Cristóbalen_US
dc.contributor.authorLorenzo-García, José Manuelen_US
dc.contributor.authorParrilla-Toribio, Dácilen_US
dc.contributor.authorCarrillo-García, Tanyaen_US
dc.contributor.authorMartín-González, Juan Carlosen_US
dc.date.accessioned2022-09-20T15:46:35Z-
dc.date.available2022-09-20T15:46:35Z-
dc.date.issued2022en_US
dc.identifier.issn2079-6382en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/118309-
dc.description.abstractThe incidence of secondary infections in critically ill coronavirus disease 2019 (COVID-19) patients is worrisome. We investigated whether selective digestive decontamination (SDD) added to infection control measures during an intensive care unit (ICU) stay modified these infection rates. Methods: A retrospective observational cohort study was carried out in four ICUs in Spain. All consecutive ventilated patients with a SARS-CoV-2 infection engaged in national infection control programs between 1 March and 10 December 2020 were investigated. Patients were grouped into two cohorts according to the site of ICU admission. Secondary relevant infections were included. Infection densities corresponding to ventilator-associated pneumonia (VAP), catheter bacteremia, secondary bacteremia, and multi-resistant germs were obtained as the number of events per 1000 days of exposure and were compared between SDD and non-SDD groups using Poisson regression. Factors that had an independent association with mortality were identified using multidimensional logistic analysis. Results: There were 108 patients in the SDD cohort and 157 in the non-SDD cohort. Patients in the SDD cohort showed significantly lower rates (p < 0.001) of VAP (1.9 vs. 9.3 events per 1000 ventilation days) and MDR infections (0.57 vs. 2.28 events per 1000 ICU days) and a non-significant reduction in secondary bacteremia (0.6 vs. 1.41 events per 1000 ICU days) compared with those in the non-SDD cohort. Infections caused by MDR pathogens occurred in 5 patients in the SDD cohort and 21 patients in the non-SDD cohort (p = 0.006). Differences in mortality according to SDD were not found. Conclusion: The implementation of SDD in infection control programs significantly reduced the incidence of VAP and MDR infections in critically ill SARS-CoV-2 infected patients.en_US
dc.languageengen_US
dc.relation.ispartofAntibioticsen_US
dc.sourceAntibiotics [EISSN 2079-6382], v. 11 (8), (Agosto 2022)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3202 Epidemologiaen_US
dc.subject.otherBacterialen_US
dc.subject.otherCovid-19en_US
dc.subject.otherDecontaminationen_US
dc.subject.otherDrug Resistanceen_US
dc.subject.otherInfection Controlen_US
dc.subject.otherPneumoniaen_US
dc.subject.otherSars-Cov-2en_US
dc.subject.otherVentilator-Associateden_US
dc.titleCOVID-19 secondary infections in ICU patients and prevention control measures: a preliminary prospective multicenter studyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/antibiotics11081016en_US
dc.identifier.scopus85137369495-
dc.contributor.orcid0000-0003-3927-3236-
dc.contributor.orcidNO DATA-
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dc.contributor.authorscopusid55518542700-
dc.contributor.authorscopusid6505902341-
dc.contributor.authorscopusid57758277800-
dc.contributor.authorscopusid57210737317-
dc.contributor.authorscopusid57202288716-
dc.contributor.authorscopusid36126680500-
dc.contributor.authorscopusid15049434600-
dc.contributor.authorscopusid57393941800-
dc.contributor.authorscopusid6505618414-
dc.contributor.authorscopusid57210737428-
dc.contributor.authorscopusid57571432900-
dc.contributor.authorscopusid6603384845-
dc.identifier.eissn2079-6382-
dc.identifier.issue8-
dc.relation.volume11en_US
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.description.numberofpages13en_US
dc.utils.revisionen_US
dc.date.coverdateAgosto 2022en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-INFen_US
dc.description.sjr0,792
dc.description.jcr4,8
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,5
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Grupo de investigaciones infecciosas, nutricionales e inflamatorias en pacientes hospitalarios / Study Group on infectious, nutritional and inflammatory diseases in hospitalized patients-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR Estadística-
crisitem.author.deptDepartamento de Matemáticas-
crisitem.author.orcid0000-0003-3927-3236-
crisitem.author.orcid0000-0003-1681-7165-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgDepartamento de Matemáticas-
crisitem.author.fullNameRuiz Santana, Sergio-
crisitem.author.fullNameSaavedra Santana, Pedro-
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