Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/114760
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dc.contributor.authorFerriol Buñola, Pereen_US
dc.contributor.authorToledo Marante, Francisco Javieren_US
dc.contributor.authorMediavilla Pérez, María Jesúsen_US
dc.contributor.authorLeón, Juan F.en_US
dc.contributor.authorBrouard Martín,Ignacioen_US
dc.contributor.authorEstevez, Francisco J.en_US
dc.contributor.authorGuedes Alonso, Raico Ivánen_US
dc.contributor.authorSantana, José Juanen_US
dc.contributor.authorToledo, Christian C.en_US
dc.date.accessioned2022-05-17T08:52:39Z-
dc.date.available2022-05-17T08:52:39Z-
dc.date.issued2014en_US
dc.identifier.isbn84-697-0471-0en_US
dc.identifier.urihttp://hdl.handle.net/10553/114760-
dc.description.abstractThe marine sponge Myxilla sp from Canary Islands is a rich source of steroids. The compounds where identified as stigmast-5-en-3β-ol (β-sitosterol) (75%), stigmast-5,25-dien-3β-ol (7%), stigmast-5,24(25)- dien-3β-ol (2%) and stigmast-5,23-dien-3β-ol (16%). The mixture of stigmasterols has the aspect of a white solid, is homogeneous by TLC and shows the physical properties as the main β-sitosterol: m.p. 277-278ºC, [α]D25ºC = -15,2º (c 0,2; CHCl3). Myxilla sp is also a rich source of pyrimidines and ceramides. The compounds where identified as uracil, thymine, a ceramide mixture and a ceramide-1-phosphate mixture. The 1:1 mixture of pyrimidines has the aspect of a white solid and is homogeneous by TLC. Although it had been isolated from sponges from Indonesia, this is the first time described for the genus Myxilla. The ceramide-1-phosphate mixture has the aspect of a white solid and also is homogeneous by TLC (Rf in agreement with the bibliography). The structures were confirmed by HRMS, HPLC-MS and two-dimensional nuclear magnetic resonance spectroscopy (COSY, NOESY, HSQC and HMBC). The marine sponge Ircinia sp from Canary Islands is a rich source of sesterterpenes. The compounds where identified as (8Z,13E,18R,20Z)-strobilinin and (8E,13Z,18R,20Z)-strobilinin. The mixture of strobilinins has the appearance of oil and is homogeneous by TLC. In 13C-NMR spectroscopy we can see a doubling of signals of the carbons 8 (δ 134.5/ 135.1), 10 (δ 123.5/ 124.5), 13 (δ 134.9/ 135.7) and 15 (δ 123.9/ 125.1), which informs us that the marine natural product is a mixture of the stereoisomers (8Z, 13E) and (8E, 13Z), in agreement with the described in bibliography. The structures were confirmed by HRMS, and two-dimensional nuclear magnetic resonance spectroscopy (COSY, HSQC and HMBC). The marine sponge Verongia aerophoba from Canary Islands is a rich source of bromotyrosine derived cytotoxics. To obtain enough of the bioactive compounds for application in human therapy, sponges have to be cultured. Before sponge mariculture is accepted as a commercially viable method of supplying bioactive metabolites, it must be demonstrated that adequate production of sponge biomass and metabo- lite is possible. In this study we provide recent data related with both aspects. Sponge growth rates have been measured in terms of projected area, and the production of three main metabolites (11R,17R-epi- Fistularin-3, Verongiolide and Verongic Acid) in diferent culture conditions in fish farm effluents have been measured by HPLC (reverse phase, methanol/ water as eluent). The results show that the bioprocess is feasible. The progresses towards quantification of cytotoxic and antileukemic factors (Aeroplysininnone) also will be presented.en_US
dc.languageengen_US
dc.sourceBook of Abstracts submitted to the IV Congress of Marine Sciences. Las Palmas de Gran Canaria, June 11th to 13th 2014, p. 251en_US
dc.subject251092 Acuicultura marinaen_US
dc.subject251001 Oceanografía biológicaen_US
dc.subject251002 Oceanografía químicaen_US
dc.titleBiologically active sponge metabolites from Canary Islandsen_US
dc.typeinfo:eu-repo/semantics/conferenceobjecten_US
dc.typeConferenceObjecten_US
dc.relation.conferenceIV Congress of Marine Sciencesen_US
dc.description.lastpage251en_US
dc.description.firstpage251en_US
dc.investigacionCienciasen_US
dc.type2Actas de congresosen_US
dc.description.numberofpages1en_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-BASen_US
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.orcid0000-0002-6847-8460-
crisitem.author.orcid0000-0002-7842-591X-
crisitem.author.orcid0000-0002-9189-9589-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.fullNameFerriol Buñola, Pere-
crisitem.author.fullNameToledo Marante, Francisco Javier-
crisitem.author.fullNameMediavilla Pérez, María Jesús-
crisitem.author.fullNameBrouard Martín, Ignacio-
crisitem.author.fullNameGuedes Alonso, Raico Iván-
crisitem.event.eventsstartdate11-06-2014-
crisitem.event.eventsenddate13-06-2014-
Appears in Collections:Actas de congresos
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