Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/113600
DC FieldValueLanguage
dc.contributor.authorOrtega, Leireen_US
dc.contributor.authorQuesada, Jessicaen_US
dc.contributor.authorRuiz Reyes, Antonioen_US
dc.contributor.authorConde De Felipe, Magnolia Maríaen_US
dc.contributor.authorFerrer Quintana, Otilia Rosaen_US
dc.contributor.authorRodríguez Guisado, Franciscoen_US
dc.contributor.authorMolina Caballero, José Manuelen_US
dc.date.accessioned2022-01-31T08:36:08Z-
dc.date.available2022-01-31T08:36:08Z-
dc.date.issued2022en_US
dc.identifier.issn1756-3305en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/113600-
dc.description.abstractDue to increased anthelmintic resistance, alternative methods to drugs are necessary to control gastrointestinal nematodes (GINs). Some of the most promising alternatives are based on the immune response of the host, such as the selection of genetically resistant breeds or the use of vaccines against these parasites. Given the limited information available on the immune response against GINs in goats, this study investigated the local immune response of goat kids of an indigenous Canary Islands breed (Majorera breed) experimentally infected with Teladorsagia circumcincta, one of the most pathogenic and prevalent GIN species. Methods: For this purpose, the relationship between different parasitological (number of mature and immature worms, worm length, and number of intrauterine eggs) and immunological parameters at the local level (related to both the humoral and cellular immune response) was analyzed at early (1 week post-infection [wpi]) and late (8 wpi) stages of infection. Results: Primary infection of goat kids with T. circumcincta infective larvae (L3) generated a complex immune response that could be defined as Th2 type, characterized by increased infiltration in abomasal tissues of several effector cells as well as a progressive presence of specific antibodies against parasitic antigens in the gastric mucus. Cellular responses were evidenced from 1 wpi onward, showing an increase in antigen-presenting cells and various lymphocyte subsets in the gastric mucosa. Conclusions: The complexity of the host response was evidenced by statistically significant changes in the number of all these subpopulations (MHCII+, CD4+, CD8+, γδ+, CD45R+, IgA+, and IgG+), as well as in the evolution of the relative cytokine gene expression. From a functional point of view, negative associations were observed between the number of most of the immune cells (CD4, IgA, IgG, and CD45R cells) and parameters that could be related to the fecundity of worms, a phenomenon that was especially evident when the number of IgG and CD45R cells or the specific IgA levels of the gastric mucus were compared with parasitological parameters such as the female worm length or fecal egg counts at 8 wpi. Graphical Abstract: [Figure not available: see fulltext.]en_US
dc.languageengen_US
dc.relation.ispartofParasites And Vectorsen_US
dc.sourceParasites and Vectors[EISSN 1756-3305],v. 15 (1), (Diciembre 2022)en_US
dc.subject310907 Patologíaen_US
dc.subject.otherAbomasal Mucosaen_US
dc.subject.otherCellular Responseen_US
dc.subject.otherGoaten_US
dc.subject.otherImmunoglobulinsen_US
dc.subject.otherTeladorsagia Circumcinctaen_US
dc.titleLocal immune response of Canarian Majorera goats infected with Teladorsagia circumcinctaen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s13071-021-05145-yen_US
dc.identifier.scopus85123014747-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcid0000-0002-8338-2512-
dc.contributor.authorscopusid56719235600-
dc.contributor.authorscopusid57416571000-
dc.contributor.authorscopusid57201387360-
dc.contributor.authorscopusid57188974191-
dc.contributor.authorscopusid7003583407-
dc.contributor.authorscopusid21641919200-
dc.contributor.authorscopusid57218216797-
dc.identifier.eissn1756-3305-
dc.identifier.issue1-
dc.relation.volume15en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages10en_US
dc.utils.revisionen_US
dc.date.coverdateDiciembre 2022en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr0,961
dc.description.jcr3,2
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,6
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUSA-ONEHEALTH1: Epidemiología, Medicina Preventiva Veterinaria y Zoonosis-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-0668-5496-
crisitem.author.orcid0000-0001-9038-042X-
crisitem.author.orcid0000-0002-4968-5333-
crisitem.author.orcid0000-0002-8338-2512-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.fullNameRuiz Reyes, Antonio-
crisitem.author.fullNameConde De Felipe, Magnolia María-
crisitem.author.fullNameFerrer Quintana, Otilia Rosa-
crisitem.author.fullNameRodríguez Guisado, Francisco-
crisitem.author.fullNameMolina Caballero, José Manuel-
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