Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/113060
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dc.contributor.authorRodríguez, Ireneen_US
dc.contributor.authorSaavedra Díaz, Ester Gloriaen_US
dc.contributor.authorDel Rosario, Henocen_US
dc.contributor.authorPerdomo Díaz, Juanen_US
dc.contributor.authorQuintana Aguiar, José Martínen_US
dc.contributor.authorPrencipe, Filippoen_US
dc.contributor.authorOliva, Paolaen_US
dc.contributor.authorRomagnoli, Romeoen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.date.accessioned2021-12-20T10:11:59Z-
dc.date.available2021-12-20T10:11:59Z-
dc.date.issued2021en_US
dc.identifier.issn1661-6596en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/113060-
dc.description.abstractThe World Health Organization reported that approximately 324,000 new cases of melanoma skin cancer were diagnosed worldwide in 2020. The incidence of melanoma has been increasing over the past decades. Targeting apoptotic pathways is a potential therapeutic strategy in the transition to preclinical models and clinical trials. Some naturally occurring products and synthetic derivatives are apoptosis inducers and may represent a realistic option in the fight against the disease. Thus, chalcones have received considerable attention due to their potential cytotoxicity against cancer cells. We have previously reported a chalcone containing an indole and a pyridine heterocyclic rings and an α-bromoacryloylamido radical which displays potent antiproliferative activity against several tumor cell lines. In this study, we report that this chalcone is a potent apoptotic inducer for human melanoma cell lines SK-MEL-1 and MEL-HO. Cell death was associated with mitochon-drial cytochrome c release and poly(ADP-ribose) polymerase cleavage and was prevented by a non-specific caspase inhibitor. Using SK-MEL-1 as a model, we found that the mechanism of cell death involves (i) the generation of reactive oxygen species, (ii) activation of the extrinsic and intrinsic apoptotic and mitogen-activated protein kinase pathways, (iii) upregulation of TRAIL, DR4 and DR5, (iv) downregulation of p21Cip1/WAF1 and, inhibition of the NF-κB pathway.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.sourceInternational Journal of Molecular Sciences [ISSN 1661-6596], v. 22 (24), 13462, (Diciembre 2021)en_US
dc.subject.otherApoptosisen_US
dc.subject.otherCaspasesen_US
dc.subject.otherCytotoxicityen_US
dc.subject.otherExtracellular Signal-Regulated Kinasesen_US
dc.subject.otherHybrid Chalconesen_US
dc.subject.otherMelanomaen_US
dc.subject.otherMitogen-Activated Protein Kinaseen_US
dc.subject.otherReactive Oxygen Speciesen_US
dc.titleApoptosis pathways triggered by a potent antiproliferative hybrid chalcone on human melanoma cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms222413462en_US
dc.identifier.scopus85121055307-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
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dc.contributor.authorscopusid57370954700-
dc.contributor.authorscopusid57190224633-
dc.contributor.authorscopusid57190227049-
dc.contributor.authorscopusid55750901700-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid56176991100-
dc.contributor.authorscopusid57189465631-
dc.contributor.authorscopusid7101729609-
dc.contributor.authorscopusid7003810011-
dc.identifier.eissn1422-0067-
dc.identifier.issue24-
dc.relation.volume22en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.notasThis article belongs to the Special Issue Cell Apoptosisen_US
dc.utils.revisionen_US
dc.date.coverdateDiciembre 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,176-
dc.description.jcr6,208-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
dc.description.miaricds10,8-
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-1717-386X-
crisitem.author.orcid0000-0002-0163-393X-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSaavedra Díaz, Ester Gloria-
crisitem.author.fullNameDel Rosario García, Henoc-
crisitem.author.fullNamePerdomo Díaz, Juan-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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