Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/112685
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dc.contributor.authorGlenn, AJen_US
dc.contributor.authorHernnandez-Alonso, Pen_US
dc.contributor.authorKendall, CWCen_US
dc.contributor.authorMartinez-Gonzalez, MAen_US
dc.contributor.authorCorella, Den_US
dc.contributor.authorFito, Men_US
dc.contributor.authorMartinez, JAen_US
dc.contributor.authorAlonso-Gomez, AMen_US
dc.contributor.authorWarnberg, Jen_US
dc.contributor.authorVioque, Jen_US
dc.contributor.authorRomaguera, Den_US
dc.contributor.authorLopez-Miranda, Jen_US
dc.contributor.authorEstruch, Ren_US
dc.contributor.authorTinahones, FJen_US
dc.contributor.authorLapetra, Jen_US
dc.contributor.authorSerra-Majem, Lluísen_US
dc.contributor.authorBueno-Cavanillas, Aen_US
dc.contributor.authorTur, JAen_US
dc.contributor.authorCelada, SRen_US
dc.contributor.authorPinto, Xen_US
dc.contributor.authorDelgado-Rodriguez, Men_US
dc.contributor.authorMatia-Martin, Pen_US
dc.contributor.authorVidal, Jen_US
dc.contributor.authorMas-Fontao, Sen_US
dc.contributor.authorDaimiel, Len_US
dc.contributor.authorRos, Een_US
dc.contributor.authorJenkins, DJAen_US
dc.contributor.authorToledo, Een_US
dc.contributor.authorSorli, JVen_US
dc.contributor.authorCastaner, Oen_US
dc.contributor.authorAbete, Ien_US
dc.contributor.authorRodriguez, AMen_US
dc.contributor.authorFernández Barceló, O.en_US
dc.contributor.authorOncina-Canovas, Aen_US
dc.contributor.authorKonieczna, Jen_US
dc.contributor.authorGarcia-Rios, Aen_US
dc.contributor.authorCasas, Ren_US
dc.contributor.authorGomez-Perez, AMen_US
dc.contributor.authorSantos-Lozano, JMen_US
dc.contributor.authorVazquez-Ruiz, Zen_US
dc.contributor.authorPortoles, Oen_US
dc.contributor.authorSchroder, Hen_US
dc.contributor.authorZulet, MAen_US
dc.contributor.authorEguaras, Sen_US
dc.contributor.authorLete, ISen_US
dc.contributor.authorZomeno, MDen_US
dc.contributor.authorSievenpiper, JLen_US
dc.contributor.authorSalas-Salvado, Jen_US
dc.date.accessioned2021-11-16T14:53:42Z-
dc.date.available2021-11-16T14:53:42Z-
dc.date.issued2021en_US
dc.identifier.issn0261-5614en_US
dc.identifier.urihttp://hdl.handle.net/10553/112685-
dc.description.abstractBackground & aims: The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial. Methods: PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors. Results: After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P < 0.001), fasting glucose (−0.47 mg/dL [−0.83, −0.11], P = 0.01), triglycerides (−1.29 mg/dL [−2.31, −0.28], P = 0.01), waist circumference (WC) (−0.51 cm [−0.59, −0.43], P < 0.001), and body mass index (BMI) (−0.17 kg/m2 [−0.19, −0.15], P < 0.001). A 1-SD increase in the DASH diet score was significantly associated with lower HbA1c (−0.03% [−0.04, −0.02], P < 0.001), glucose (−0.84 mg/dL [−1.18, −0.51], P < 0.001), triglycerides (−3.38 mg/dL [−4.37, −2.38], P < 0.001), non-HDL-cholesterol (−0.47 mg/dL [−0.91, −0.04], P = 0.03), WC (−0.69 cm [−0.76, −0.60 cm], P < 0.001), BMI (−0.25 kg/m2 [−0.28, −0.26 kg/m2], P < 0.001), systolic blood pressure (−0.57 mmHg [−0.81, −0.32 mmHg], P < 0.001), diastolic blood pressure (−0.15 mmHg [−0.29, −0.01 mmHg], P = 0.03), and with higher HDL-cholesterol (0.21 mg/dL [0.09, 0.34 mg/dL, P = 0.001]). Similar associations were seen when both diet scores were assessed as quartiles, comparing extreme categories of adherence. Conclusions: Among older adults at high cardiovascular risk with MetS, greater adherence to the Portfolio and DASH diets showed significant favourable prospective associations with several clinically relevant cardiometabolic risk factors. Both diets are likely beneficial for cardiometabolic risk reduction.en_US
dc.languageengen_US
dc.relationEfecto de una intervención intensiva de pérdida de peso con dieta Mediterránea hipocalórica, actividad física y tratamiento conductual sobre la prevención primaria cardiovascular: ensayo PREDIMED-Plusen_US
dc.relationEfecto de Una Pérdida de Peso Con Dieta Mediterránea Hipocalórica y Promoción de la Actividad Física en la Prevención Primaria Cardiovascularen_US
dc.relationEfecto de la dieta mediterránea hopocalórica y promoción de la actividad física en prevención primaria cardiovascular.Estudio piloto sobre marcadores intermedios.en_US
dc.relation.ispartofClinical Nutritionen_US
dc.sourceClinical Nutrition [ISSN 0261-5614], v. 40(5),p. 2825-2836, (Mayo 2021)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherPORTFOLIO dieten_US
dc.subject.otherDASH dieten_US
dc.subject.otherCardiometabolic risken_US
dc.subject.otherDietary patternsen_US
dc.subject.otherMetabolic syndromeen_US
dc.subject.otherPREDIMED-Plus trialen_US
dc.titleLongitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus studyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.clnu.2021.03.016en_US
dc.identifier.pmid33933749-
dc.identifier.scopus2-s2.0-85104911946-
dc.identifier.isiWOS:000654716700002-
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dc.description.lastpage2836en_US
dc.identifier.issue5-
dc.description.firstpage2825en_US
dc.relation.volume40en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages10en_US
dc.utils.revisionen_US
dc.date.coverdateMayo 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,553
dc.description.jcr7,643
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds11,0
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
crisitem.project.principalinvestigatorSerra Majem, Luis-
crisitem.project.principalinvestigatorSerra Majem, Luis-
crisitem.project.principalinvestigatorSerra Majem, Luis-
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