Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/111618
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dc.contributor.authorVerdu, Samuelen_US
dc.contributor.authorPerez, Alberto J.en_US
dc.contributor.authorCarrascosa Iruzubieta, Conrado Javieren_US
dc.contributor.authorBarat, José M.en_US
dc.contributor.authorTalens, Pauen_US
dc.contributor.authorGrau, Raúlen_US
dc.date.accessioned2021-09-13T12:12:15Z-
dc.date.available2021-09-13T12:12:15Z-
dc.date.issued2021en_US
dc.identifier.issn1661-7827en_US
dc.identifier.urihttp://hdl.handle.net/10553/111618-
dc.description.abstractNitrocompounds are present in the environment and human diet and form part of vegetables and processed meat products as additives. These compounds are related to negative impacts on human and animal health. The protective effect of ascorbic acid has been demonstrated by some biological systems as regards several nitrocompounds. This work focused on studying the possibility of modeling this effect on nitrite toxicity with the model Caenorhabditis elegans. The three factors studied in this work were ascorbic acid concentration, nitrite exposure concentration, and presence/absence of food. The protective effect was evaluated by scoring lethality and its impact on behavior by means of multivariate statistical methods and imaging analytics. The effects of nitrite and the influence of food availability were evidenced. Apart from increasing lethality, nitrite had disruption effects on movements. All the observed symptoms reduced when ascorbic acid was ad-ministered, and it diminished lethality in all cases. Ascorbic acid maintained nematodes’ postural capacities. The results suggest that nitrites’ nonspecific toxicity in C. elegans can be mitigated by ascorbic acid, as previously evidenced in other biological systems. Thus, our results reveal the ability of C. elegans to reproduce the known protective effect of ascorbic acid against nitrite.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Environmental Research and Public Healthen_US
dc.sourceInternational Journal of Environmental Research and Public Health [ISSN 1661-7827], 18(4), 2068, (Febrero 2021)en_US
dc.subject330990 Microbiología de alimentosen_US
dc.subject.otherAscorbic aciden_US
dc.subject.otherBehavior imagingen_US
dc.subject.otherC. elegansen_US
dc.subject.otherMultivariate analyticsen_US
dc.subject.otherNitriteen_US
dc.subject.otherProtective effecten_US
dc.titleCaenorhabditis elegans to model the capacity of ascorbic acid to reduce acute nitrite toxicity under different feed conditions: Multivariate analytics on behavioral imagingen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typearticleen_US
dc.identifier.doi10.3390/ijerph18042068en_US
dc.identifier.pmid33672539-
dc.identifier.scopus2-s2.0-85100930925-
dc.contributor.orcid#NODATA#-
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dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.identifier.issue4-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr0,747
dc.description.jcr3,39
dc.description.sjrqQ2
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.ssciSSCI
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptOHAPA (Higiene y Protección Alimentaria) Grupo de Investigación-
crisitem.author.deptPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-2802-7873-
crisitem.author.parentorgPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.fullNameCarrascosa Iruzubieta, Conrado Javier-
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