Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/111392
DC FieldValueLanguage
dc.contributor.authorLopez-Nava, Gontranden_US
dc.contributor.authorAsokkumar, Ravishankaren_US
dc.contributor.authorRull, Angelen_US
dc.contributor.authorFernandez-Corbelleen_US
dc.contributor.authorBautista Castaño, Inmaculadaen_US
dc.contributor.authorDayyeh, Barham Abuen_US
dc.date.accessioned2021-08-06T09:32:16Z-
dc.date.available2021-08-06T09:32:16Z-
dc.date.issued2020en_US
dc.identifier.issn0960-8923en_US
dc.identifier.urihttp://hdl.handle.net/10553/111392-
dc.description.abstractIntroduction: Endoscopic gastroplasty and gastric volume reduction techniques have been shown to achieve significant weight loss and improvement in comorbid conditions. The objective of this study is to assess the feasibility and safety of a novel fully automated, operator-independent endoscopic suturing system (EndoZip™) for minimally invasive treatment of obesity. Design: Single-center pilot feasibility study. Patients: Eleven patients with a body mass index (BMI) of 30 to 40 kg/m2 with or without obesity-associated comorbidity. Interventions: Gastric volume reduction with EndoZip™ system. Main Outcome Measurements: Primary outcome was to assess the technical feasibility and safety. The secondary outcome was to determine %total body weight loss (TBWL) and %excess weight loss (EWL) at 6 months. Results: The mean ± SD age was 42.7 ± 5.6 years, and the mean ± SD BMI was 36.9 ± 2.8 kg/m2. A majority (64%) were men. The procedure was technically successful (100%) in all patients. A median of 3 (range, 2–4) full-thickness sutures were placed, and the mean procedure time was 54.6 ± 23.9 (23–100) min. No immediate complications occurred, and all were discharged in 24 h. One patient developed respiratory infection 3 days after the procedure and required hospitalization. The infection was mild and resolved with antibiotic treatment. At 6-month follow-up, the mean ± SD TBWL, %TBWL, and %EWL were 17.8 ± 6.7 kg, 16.2 ± 6.0%, and 54.3 ± 28.4%, respectively (p < 0.001). Limitations: Limited number of patients. Conclusion: Our first-in-human study showed that the Endozip™ device could be safely used for the treatment of obesity. The early weight loss results are promising. An extended feasibility study on a larger sample size is being planned (Clinicaltrials.gov. NCT03472196).en_US
dc.languageengen_US
dc.relation.ispartofObesity Surgeryen_US
dc.sourceObesity Surgery [ISSN 0960-8923], n. 30, p. 1696–1703en_US
dc.subject32 Ciencias médicasen_US
dc.subject320503 Gastroenterologíaen_US
dc.subject3213 Cirugíaen_US
dc.subject.otherAutomatic suturingen_US
dc.subject.otherBariatric endoscopyen_US
dc.subject.otherEndoscopic gastroplastyen_US
dc.subject.otherEndoZipen_US
dc.subject.otherObesityen_US
dc.subject.otherWeight lossen_US
dc.titleSafety and Feasibility of a Novel Endoscopic Suturing Device (EndoZip TM) for Treatment of Obesity: First-in-Human Studyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typearticleen_US
dc.identifier.doi10.1007/s11695-019-04370-wen_US
dc.identifier.pmid31898051-
dc.identifier.scopus2-s2.0-85077608104-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid0000-0003-2822-6100-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.description.lastpage1703en_US
dc.identifier.issue5-
dc.description.firstpage1696en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.date.coverdateMayo 2020en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,474
dc.description.jcr4,129
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0001-9257-8739-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBautista Castaño, Inmaculada-
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