Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/111389
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dc.contributor.authorLopez-Nava, Gontranden_US
dc.contributor.authorJaruvongvanich, Veeravichen_US
dc.contributor.authorStorm, Andrew C.en_US
dc.contributor.authorMaselli, Daniel B.en_US
dc.contributor.authorBautista Castaño, Inmaculadaen_US
dc.contributor.authorVargas, Eric J.en_US
dc.contributor.authorMatar, Reemen_US
dc.contributor.authorAcosta, Andresen_US
dc.contributor.authorAbu Dayyeh, Barham K.en_US
dc.date.accessioned2021-08-06T08:56:18Z-
dc.date.available2021-08-06T08:56:18Z-
dc.date.issued2020en_US
dc.identifier.issn0960-8923en_US
dc.identifier.urihttp://hdl.handle.net/10553/111389-
dc.description.abstractBackground: The intragastric balloon (IGB) is commonly used for weight loss. Identifying patients who are most likely to tolerate and benefit from IGB therapy will optimize outcomes. Our aims were to prospectively utilize a gastric emptying study to predict intolerance and treatment response with a single fluid-filled IGB and to develop a physiologic prediction model with a treatment algorithm. Materials and Methods: A total of 32 patients had a gastric emptying study before and 2–3 months after placement of an IGB. Multiple logistic regression analyses were performed to calculate likelihood ratios and to develop a physiologic prediction model. Results: Patients in the higher gastric retention quartile at baseline had a 6.2-time higher likelihood ratio for early balloon removal secondary to intolerance (p = 0.013). Utilizing baseline gastric emptying to predict intolerance to the IGB may have prevented 75% of early removal cases. Decreased gastric emptying at 3 months after balloon placement was significantly correlated with percent total body weight loss (%TWBL) at 6 and 12 months (p = 0.01 and p = 0.014, respectively). At 6 months after IGB, patients with no change in their gastric emptying at 3 months lost significantly less weight compared with those with increased gastric retention (median %TBWL = 9.0% [4.5–14.7] versus 17.3% [12.2–24.4], p = 0.016). Conclusion: Utilizing gastric emptying as a physiologic predictor of intolerance and response to the single fluid-filled IGB can improve outcomes. This pilot feasibility trial ushers in the era of personalized endoscopic bariatric therapies to maximize patients’ tolerance, cost-effectiveness, and meaningful weight loss.en_US
dc.languageengen_US
dc.relation.ispartofObesity Surgeryen_US
dc.sourceObesity Surgery [ISSN 0960-8923], n. 30, p. 3347–3353en_US
dc.subject320503 Gastroenterologíaen_US
dc.subject.otherGastric emptyingen_US
dc.subject.otherIntoleranceen_US
dc.subject.otherIntragastric balloonen_US
dc.subject.otherObesityen_US
dc.subject.otherPersonalized medicineen_US
dc.subject.otherWeight lossen_US
dc.titlePersonalización de terapias endoscópicas bariátricas y metabólicas basadas en la fisiología: un estudio de viabilidad prospectivo con un solo balón intragástrico lleno de líquidoen_US
dc.title.alternativePersonalization of Endoscopic Bariatric and Metabolic Therapies Based on Physiology: a Prospective Feasibility Study with a Single Fluid-Filled Intragastric Balloonen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typearticleen_US
dc.identifier.doi10.1007/s11695-020-04581-6en_US
dc.identifier.pmid32285333-
dc.identifier.scopus2-s2.0-85083763397-
dc.contributor.orcid#NODATA#-
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dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
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dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.identifier.issue9-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,474
dc.description.jcr4,129
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0001-9257-8739-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBautista Castaño, Inmaculada-
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