Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/108017
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dc.contributor.authorMachín Pérez, Cynthiaen_US
dc.contributor.authorCorripio-Miyar, Yolandaen_US
dc.contributor.authorHernández Vega, Julia Natividaden_US
dc.contributor.authorPérez Hernández, Taraen_US
dc.contributor.authorHayward, Adam D.en_US
dc.contributor.authorWright, Harry W.en_US
dc.contributor.authorPrice, Daniel R.G.en_US
dc.contributor.authorMatthews, Jacqueline B.en_US
dc.contributor.authorMcNeilly, Tom N.en_US
dc.contributor.authorNisbet, Alasdair J.en_US
dc.contributor.authorGonzález Pérez, Jorge Franciscoen_US
dc.date.accessioned2021-06-28T08:18:57Z-
dc.date.available2021-06-28T08:18:57Z-
dc.date.issued2021en_US
dc.identifier.issn0928-4249en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/108017-
dc.description.abstractDue to increased anthelmintic resistance, complementary methods to drugs are necessary to control gastrointestinal nematodes (GIN). Vaccines are an environmentally-friendly and promising option. In a previous study, a Teladorsagia circumcincta recombinant sub-unit vaccine was administered to two sheep breeds with different levels of resistance against GIN. In the susceptible Canaria Sheep (CS) breed, vaccinates harboured smaller worms with fewer eggs in utero than the control group. Here, we extend this work, by investigating the cellular and humoral immune responses of these two sheep breeds following vaccination and experimental infection with T. circumcincta. In the vaccinated CS group, negative associations between antigen-specific IgA, IgG2 and Globule Leukocytes (GLs) with several parasitological parameters were established as well as a higher CD4+/CD8+ ratio than in control CS animals, suggesting a key role in the protection induced by the vaccine. In the more resistant Canaria Hair Breed (CHB) sheep the vaccine did not significantly impact on the parasitological parameters studied and none of these humoral associations were observed in vaccinated CHB lambs, although CHB had higher proportions of CD4+ and CD8+ T cells within the abomasal lymph nodes, suggesting higher mucosal T cell activation. Each of the component proteins in the vaccine induced an increase in immunoglobulin levels in vaccinated groups of each breed. However, levels of immunoglobulins to only three of the antigens (Tci-MEP-1, Tci-SAA-1, Tci-ASP-1) were negatively correlated with parasitological parameters in the CS breed and they may be, at least partially, responsible for the protective effect of the vaccine in this breed. These data could be useful for improving the current vaccine prototype.en_US
dc.languageengen_US
dc.relation.ispartofVeterinary Researchen_US
dc.sourceVeterinary Research [ISSN 0928-4249], v. 52, 89 (2021)en_US
dc.subject240112 Parasitología animalen_US
dc.subject310903 Inmunologíaen_US
dc.subject.otherCellular Responseen_US
dc.subject.otherGenetic Resistanceen_US
dc.subject.otherGlobule Leukocytesen_US
dc.subject.otherImmune Responseen_US
dc.subject.otherImmunoglobulinsen_US
dc.subject.otherNematode Vaccineen_US
dc.subject.otherSheepen_US
dc.subject.otherTeladorsagia Circumcinctaen_US
dc.titleCellular and humoral immune responses associated with protection in sheep vaccinated against Teladorsagia circumcinctaen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s13567-021-00960-8en_US
dc.identifier.scopus85108100972-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcid0000-0002-3843-2509-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.authorscopusid57208575626-
dc.contributor.authorscopusid14624902300-
dc.contributor.authorscopusid57188977277-
dc.contributor.authorscopusid57208586521-
dc.contributor.authorscopusid35075879000-
dc.contributor.authorscopusid57214577282-
dc.contributor.authorscopusid13606370700-
dc.contributor.authorscopusid25422557800-
dc.contributor.authorscopusid36978592100-
dc.contributor.authorscopusid7005065716-
dc.contributor.authorscopusid7404492965-
dc.identifier.eissn1297-9716-
dc.identifier.issue1-
dc.relation.volume52en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateDiciembre 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0001-9755-7267-
crisitem.author.orcid0000-0002-3843-2509-
crisitem.author.orcid0000-0003-2919-3857-
crisitem.author.orcid0000-0001-7374-9256-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameMachín Pérez, Cynthia-
crisitem.author.fullNameHernández Vega, Julia Natividad-
crisitem.author.fullNamePérez Hernández,Tara-
crisitem.author.fullNameGonzález Pérez, Jorge Francisco-
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