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Title: Cardiopulmonary biomarkers in dogs infected by Dirofilaria immitis
Authors: Carretón Gómez, Elena 
Corbera Sánchez, Juan Alberto 
Juste de Santa Ana, Candelaria 
Morchon Garcia,Rodrigo 
Montoya Alonso, José Alberto 
UNESCO Clasification: 310904 Medicina interna
310907 Patología
240112 Parasitología animal
Issue Date: 2009
Conference: 2nd European Dirofilaria Days (SEDD 2009) 
Abstract: Dirofilaria immitis produces relevant injuries in different organs, principally at cardiovascular and pulmonary systems. Cardiopulmonary biomarkers are biological parameters that can be objectively measured and quantified as indicators of pathogenic processes (heartworm disease), or responses to a therapeutic intervention. Biomarkers are typically thought of as tools for screening, diagnosing, or monitoring of a disease process, but they may also be used to determine disease susceptibility and eligibility for specific therapies. The aim of the present study was determined the levels of cardiopulmonary biomarkers (cardiac troponin T, mioglobin and D-dimer) in dogs parasitized by D. immitis. Sixty two dogs were analyzed: 9 healthy animals (control group), 10 seropositive and amicrofilaremic dogs and 43 microfilaremic and seropositive dogs. The measurement of circulating cardiopulmonary biomarkers concentration was performed in heparinized blood using specific troponin T, myoglobin and D-dimer immunoassay system, (Cardiac Reader ® Roche Diagnostics) following manufacturer instructions. In all groups of dogs troponin T values were below the detection limit of the equipment (<0.03 ng/ml). The control group and the amicrofilaremic dogs group were myoglobin values <30 ng/ml, In the microfilaremic group a 23.26% of dogs had higher values of myoglobin (100 ng/ml). The control group presented levels of D-dimer <0.1 mg/ml. The 50% of the amicrofilaremic dogs showed detectable values of D-dimer between 0.1 and 0.5 mg/ml, not considered pathological, and 10% of dogs of this group had pathological levels of D-dimer. In the microfilaremic dogs group 27.9% had pathological values of D-dimer higher than 0.5 mg/ml. In conclusion our results suggest that in dogs infected with D. immitis biomarkers of pulmonary thromboembolism (D-dimer) were elevated, especially in microfilaremic dogs. In this group myoglobin concentration are also abnormally elevated.
ISBN: 978-84-692-3583-6
Source: 2nd European Diraofilaria Days : programme and abstracts SEDD 2009, O 12
Appears in Collections:Ponencias
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