Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/107007
Campo DC Valoridioma
dc.contributor.authorArtiles Armas, Manuelen_US
dc.contributor.authorRoque Castellano, Cristinaen_US
dc.contributor.authorFariña-Castro, Robertoen_US
dc.contributor.authorConde Martel, Aliciaen_US
dc.contributor.authorAcosta Mérida, María Asunciónen_US
dc.contributor.authorMarchena Gómez, Joaquínen_US
dc.date.accessioned2021-04-26T13:19:52Z-
dc.date.available2021-04-26T13:19:52Z-
dc.date.issued2021en_US
dc.identifier.issn1477-7819en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/107007-
dc.description.abstractBackground: Frailty has been shown to be a good predictor of post-operative complications and death in patients undergoing gastrointestinal surgery. The aim of this study was to analyze the differences between frail and non-frail patients undergoing colorectal cancer surgery, as well as the impact of frailty on long-term survival in these patients. Methods: A cohort of 149 patients aged 70 years and older who underwent elective surgery for colorectal cancer was followed-up for at least 5 years. The sample was divided into two groups: frail and non-frail patients. The Canadian Study of Health and Aging-Clinical Frailty Scale (CSHA-CFS) was used to detect frailty. The two groups were compared with regard to demographic data, comorbidities, functional and cognitive statuses, surgical risk, surgical variables, tumor extent, and post-operative outcomes, which were mortality at 30 days, 90 days, and 1 year after the procedure. Univariate and multivariate analyses were also performed to determine which of the predictive variables were related to 5-year survival. Results: Out of the 149 patients, 96 (64.4%) were men and 53 (35.6%) were women, with a median age of 75 years (IQR 72–80). According to the CSHA-CFS scale, 59 (39.6%) patients were frail, and 90 (60.4%) patients were not frail. Frail patients were significantly older and had more impaired cognitive status, worse functional status, more comorbidities, more operative mortality, and more serious complications than non-frail patients. Comorbidities, as measured by the Charlson Comorbidity Index (p = 0.001); the Lawton-Brody Index (p = 0.011); failure to perform an anastomosis (p = 0.024); nodal involvement (p = 0.005); distant metastases (p < 0.001); high TNM stage (p = 0.004); and anastomosis dehiscence (p = 0.013) were significant univariate predictors of a poor prognosis on univariate analysis. Multivariate analysis of long-term survival, with adjustment for age, frailty, comorbidities and TNM stage, showed that comorbidities (p = 0.002; HR 1.30; 95% CI 1.10–1.54) and TNM stage (p = 0.014; HR 2.06; 95% CI 1.16–3.67) were the only independent risk factors for survival at 5 years. Conclusions: Frailty is associated with poor short-term post-operative outcomes, but it does not seem to affect long-term survival in older patients with colorectal cancer. Instead, comorbidities and tumor stage are good predictors of long-term survival.en_US
dc.languageengen_US
dc.relation.ispartofWorld Journal of Surgical Oncologyen_US
dc.sourceWorld Journal of Surgical Oncology [EISSN 1477-7819],v. 19 (1), 106, (Diciembre 2021)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3213 Cirugíaen_US
dc.subject320101 Oncologíaen_US
dc.subject.otherColorectal Canceren_US
dc.subject.otherComorbidityen_US
dc.subject.otherFrailtyen_US
dc.subject.otherGeriatricsen_US
dc.titleImpact of frailty on 5-year survival in patients older than 70 years undergoing colorectal surgery for canceren_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12957-021-02221-6en_US
dc.identifier.scopus85104212796-
dc.contributor.authorscopusid56667617500-
dc.contributor.authorscopusid14032251400-
dc.contributor.authorscopusid6507213408-
dc.contributor.authorscopusid7004460826-
dc.contributor.authorscopusid14031217200-
dc.contributor.authorscopusid55089291600-
dc.identifier.eissn1477-7819-
dc.identifier.issue1-
dc.relation.volume19en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages13en_US
dc.utils.revisionen_US
dc.date.coverdateDiciembre 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr0,716
dc.description.jcr3,253
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
dc.description.miaricds10,8
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-7309-6141-
crisitem.author.orcid0000-0002-2540-3880-
crisitem.author.orcid0000-0002-7362-1110-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameArtiles Armas, Manuel-
crisitem.author.fullNameRoque Castellano, Cristina-
crisitem.author.fullNameConde Martel, Alicia-
crisitem.author.fullNameAcosta Mérida, María Asunción-
crisitem.author.fullNameMarchena Gómez, Joaquín-
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