Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/106924
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dc.contributor.authorBombardi, Cristianoen_US
dc.contributor.authorRambaldi, Anna Mariaen_US
dc.contributor.authorGaliazzo, Giorgiaen_US
dc.contributor.authorGiancola, Fiorellaen_US
dc.contributor.authorGraïc, Jean Marieen_US
dc.contributor.authorSalamanca, Giuliaen_US
dc.contributor.authorCozzi, Brunoen_US
dc.contributor.authorChiocchetti, Robertoen_US
dc.date.accessioned2021-04-19T20:19:31Z-
dc.date.available2021-04-19T20:19:31Z-
dc.date.issued2021en_US
dc.identifier.issn2076-2615en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/106924-
dc.description.abstractCompared with other mammals, the digestive system of cetaceans presents some remarkable anatomical and physiological differences. However, the neurochemical features of the enteric nervous system (ENS) in these animals have only been described in part. The present study gives a description of the nitrergic and selected peptidergic systems in the myenteric plexus (MP) and submucosal plexus (SMP) of the intestine of the bottlenose dolphin (Tursiops truncatus). The distribution and morphology of neurons immunoreactive (IR) for the neuronal nitric oxide synthase (nNOS) and Substance P (SP) were immunohistochemically studied in formalin-fixed specimens from the healthy intestine of three animals, and the data were compared with those described in the literature on other mammals (human and non-human). In bottlenose dolphins, the percentages of nitrergic neurons (expressed as median and interquartile range—IQR) were 28% (IQR = 19–29) in the MP and 1% (IQR = 0–2) in the SMP, while the percentages of SP-IR neurons were 31% (IQR = 22–37) in the MP and 41% (IQR = 24–63) in the SMP. Although morphological features of nNOS-and SP-IR neurons were similar to those reported in other mammals, we found some noticeable differences in the percentages of enteric neurons. In fact, we detected a lower proportion of nNOS-IR neurons in the SMP and a higher proportion of SP-IR neurons in the MP compared to other mammals. To the best of the authors’ knowledge, this study represents the first description and quantification of nNOS-IR neurons and the first quantification of SP-IR neurons in the intestine of a cetacean species. As nNOS and SP are important mediators of intestinal functions and the nitrergic population is an important target for many neuroenteropathies, data obtained from a healthy intestine provide a necessary basis to further investigate and understand possible functional differences and motor intestinal dysfunctions/alterations in these special mammals.en_US
dc.languageengen_US
dc.relation.ispartofAnimalsen_US
dc.sourceAnimals [EISSN 2076-2615], v. 11 (4), 1057, (Abril 2021)en_US
dc.subject240111 Patología animalen_US
dc.subject.otherCetaceansen_US
dc.subject.otherGuten_US
dc.subject.otherImmunohistochemistryen_US
dc.subject.otherIntestineen_US
dc.subject.othernNOSen_US
dc.titleNitrergic and substance p immunoreactive neurons in the enteric nervous system of the bottlenose dolphin (Tursiops truncatus) intestineen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ani11041057en_US
dc.identifier.scopus85103858204-
dc.contributor.authorscopusid6508064114-
dc.contributor.authorscopusid57188881126-
dc.contributor.authorscopusid57195631662-
dc.contributor.authorscopusid36514558000-
dc.contributor.authorscopusid57190124197-
dc.contributor.authorscopusid57222720199-
dc.contributor.authorscopusid7004475671-
dc.contributor.authorscopusid6602402979-
dc.identifier.eissn2076-2615-
dc.identifier.issue4-
dc.relation.volume11en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.notasThis article belongs to the Special Issue Recent advances in Marine Mammal Researchen_US
dc.utils.revisionen_US
dc.date.coverdateAbril 2021en_US
dc.identifier.ulpgcen_US
dc.description.sjr0,61
dc.description.jcr3,231
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,5
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.fullNameRambaldi, Anna Maria-
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