Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/106859
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dc.contributor.authorMoriczi, Melindaen_US
dc.contributor.authorPujol-Muncunill, Gemmaen_US
dc.contributor.authorMartín-Masot, Rafaelen_US
dc.contributor.authorJiménez Treviño, Santiagoen_US
dc.contributor.authorSegarra Cantón, Oscaren_US
dc.contributor.authorOchoa Sangrador, Carlosen_US
dc.contributor.authorPeña Quintana, Luisen_US
dc.contributor.authorGonzález Santana, Danielen_US
dc.contributor.authorRodríguez Martínez, Alejandroen_US
dc.contributor.authorRosell Camps, Antonioen_US
dc.contributor.authorArmas, Honorioen_US
dc.contributor.authorBarrio, Josefaen_US
dc.contributor.authorGonzález de Caldas, Rafaelen_US
dc.contributor.authorRodríguez Salas, Mónicaen_US
dc.contributor.authorBalmaseda Serrano, Elenaen_US
dc.contributor.authorDonat Aliaga, Esteren_US
dc.contributor.authorBodas Pinedo, Andrésen_US
dc.contributor.authorVaquero Sosa, Estheren_US
dc.contributor.authorVecino López, Raquelen_US
dc.contributor.authorSolar Boga, Alfonsoen_US
dc.contributor.authorMoreno Álvarez, Anaen_US
dc.contributor.authorSánchez Sánchez, Césaren_US
dc.contributor.authorTolín Hernani, Maren_US
dc.contributor.authorGutiérrez Junquera, Carolinaen_US
dc.contributor.authorMartinón Torres, Nazarethen_US
dc.contributor.authorLeis Trabazo, María Rosauraen_US
dc.contributor.authorEizaguirre, Francisco Javieren_US
dc.contributor.authorGarcía Peris, Mónicaen_US
dc.contributor.authorMedina Benítez, Enriqueen_US
dc.contributor.authorFernández Caamaño, Beatrizen_US
dc.contributor.authorVegas Álvarez, Ana Maríaen_US
dc.contributor.authorCrespo Valderrábano, Lauraen_US
dc.contributor.authorAlonso Vicente, Carmenen_US
dc.contributor.authorRubio Santiago, Javieren_US
dc.contributor.authorGalera-Martínez, Rafaelen_US
dc.contributor.authorGarcía-Romero, Ruthen_US
dc.contributor.authorRos Arnal, Ignacioen_US
dc.contributor.authorFernández Cebrián, Santiagoen_US
dc.contributor.authorLorenzo Garrido, Helenaen_US
dc.contributor.authorViada Bris, Javier Franciscoen_US
dc.contributor.authorVelasco Rodríguez-Belvis, Martaen_US
dc.contributor.authorBartolomé Porro, Juan Manuelen_US
dc.contributor.authorBlanco Rodríguez, Miriamen_US
dc.contributor.authorBarros García, Patriciaen_US
dc.contributor.authorBotija, Gonzaloen_US
dc.contributor.authorChicano Marín, Francisco Joséen_US
dc.contributor.authorLa Orden Izquierdo, Enriqueen_US
dc.contributor.authorCrehuá-Gaudiza, Elenaen_US
dc.contributor.authorNavas-López, Víctor Manuelen_US
dc.contributor.authorMartín-de-Carpi, Javieren_US
dc.date.accessioned2021-04-15T13:32:43Z-
dc.date.available2021-04-15T13:32:43Z-
dc.date.issued2020en_US
dc.identifier.issn2072-6643en_US
dc.identifier.urihttp://hdl.handle.net/10553/106859-
dc.description.abstractExclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing in children with Crohn´s disease (CD) without the adverse effects of these drugs. The aims of this study were to determine the efficacy of EEN in terms of inducing clinical remission in children newly diagnosed with CD, to describe the predictive factors of response to EEN and the need for treatment with biological agents during the first 12 months of the disease. We conducted an observational retrospective multicentre study that included paediatric patients newly diagnosed with CD between 2014–2016 who underwent EEN. Two hundred and twenty-two patients (140 males) from 35 paediatric centres were included, with a mean age at diagnosis of 11.6 ± 2.5 years. The median EEN duration was 8 weeks (IQR 6.6–8.5), and 184 of the patients (83%) achieved clinical remission (weighted paediatric Crohn’s Disease activity index [wPCDAI] < 12.5). Faecal calprotectin (FC) levels (μg/g) decreased significantly after EEN (830 [IQR 500–1800] to 256 [IQR 120–585] p < 0.0001). Patients with wPCDAI ≤ 57.5, FC < 500 μg/g, CRP >15 mg/L and ileal involvement tended to respond better to EEN. EEN administered for 6–8 weeks is effective for inducing clinical remission. Due to the high response rate in our series, EEN should be used as the first-line therapy in luminal paediatric Crohn’s disease regardless of the location of disease and disease activityen_US
dc.languageengen_US
dc.relation.ispartofNutrientsen_US
dc.sourceNutrients [ISSN 2072-6643], v. 12(4)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320503 Gastroenterologíaen_US
dc.subject.otherInflammatory bowel diseaseen_US
dc.subject.otherCrohn’s diseaseen_US
dc.subject.otherExclusive enteral nutritionen_US
dc.subject.otherCalprotectinen_US
dc.subject.otherChildrenen_US
dc.subject.otherPaediatricen_US
dc.titlePredictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNPen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typearticleen_US
dc.identifier.doi10.3390/nu12041012en_US
dc.identifier.issue4-
dc.relation.volume12en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.date.coverdateAbril 2020en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,418
dc.description.jcr5,717
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0001-6052-5894-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePeña Quintana, Luis-
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